Find Research Models

Ovary transplant and ova transfer studies, Production of targeted mutations due to the availability of several lines of embryonic stem cells

Cre Tool for conditional expression or deletion in 5HT3a+ neurons, Expression/knockout of floxed genes, Neuroscience, Optogenetics

Behavior, Carcinogenesis, General studies, Teratogenesis

Carcinogenesis, Estrogen-induced pituitary growth, Transplant immunology

Cholestasis, Cytochrome p450 pathways, Drug metabolism, Hepatotoxicity, Xenobiotic

Dopaminergic cell toxicity, Neuroscience, Parkinson's disease

Dopaminergic cell toxicity, Neuroscience, Parkinson's disease

Alzheimer's disease, Cardiovascular, Neurodegenerative diseases

Alzheimer's disease, Dementia, Memory loss, Neurodegeneration, Neuroscience, Synaptic formation and repair

Sentinel model - Heterozygous Hsd:Athymic Nude-Foxn1nu/Foxn1+

Sentinel model – Heterozygous Hsd:RH-Foxn1rnu/Foxn1+

Humanization applications, Graft vs. host disease research, Drug efficacy evaluation

Oncology research, Infectious disease, Humanization applications, NK cell role in tumorigenesis, Antibody drug efficacy evaluation

Humanization applications, Infectious disease

Carcinogenicity, Embryo donors, Toxicology

Behavior, Bioassay of nutrients, drugs, and hormones, Tumorigenicity

General purpose

General purpose

Antibody production, Autoimmune disease, Sentinel model - Heterozygous BALB/cOlaHsd-Foxn1nu/Foxn1+

DMPK efflux assay, Drug-drug interactions, Drug metabolism, Drug transporter, Efficacy assay, Formulation blood brain barrier efflux, Neuroscience, Tissue distribution

Alzheimer's disease, Depression, Huntington's disease, Memory loss, Nerve growth and development, Neuroscience, Pain, Post-traumatic stress disorder, Schizophrenia

Allergic Respiratory Disease, Leukemia, Nephrology

Cholestasis, Drug-drug interactions, Drug-induced cholestasis (DIC), Drug metabolism, Drug transporter

Ocular disease

Age-associated pathology, Cardiovascular, Immune response, Longevity, Memory, Metabolism, Motor skills, Osteoarthritis, Neoplasia, Neurobiology, Renal degeneration, Reproductive senescence, Vision and hearing

Ovarian transfer, Source of albino C57BL/6 embryos for chimera generation

Background for induced and genetically-modified models, Behavior and learning disabilities, Diet-induced obesity, Drug addiction, Superovulation

Background for induced and genetically-modified models, Behavior and learning disabilities, Diet-induced obesity, Drug addiction, Superovulation

Alzheimer's disease, Autism (ASD), Dementia, Memory loss, Synaptic formation and repair

Cre Tool for conditional expression or deletion in CamKIIa+ neurons, Expression/knockout of floxed genes, Neuroscience, Optogenetics

Cholestasis, Hepatotoxicity, Drug metabolism, Xenobiotic

Behavior, Immunology, Infection, Reproductive Biology

Only approved mouse strain for use in the Local Lymph Node Assay, a refined alternative research method for evaluating the allergic contact dermatitis potential of chemicals and compounds

Carcinogenesis, Pharmacology

Chloride transport, Cystic Fibrosis, Lung Disease, Thiocyanide transport

Autism (ASD), Neuroscience

Epilepsy, Neuronal growth and transport studies, Neuroscience, Schizophrenia

Cell adhesion, Language disorders, Synaptic Plasticity

Adenoviral vector-based gene therap, Herpes Simplex, Human metapneumovirus, Monkeypox, Mycobacterium tuberculosis, Polio, COVID-19

Asthma, Colitis, Crohn's disease, Immunology, Multiple sclerosis, Platelet defects/Platelet aggregation, Renal dysplasia, Rheumatoid arthritis, Inflammation/Autoimmune disorders, Thrombosis/Cardiac fibrosis, Vascular defects

Asthma, Colitis, Crohn's disease, Immunology, Inflammation/Autoimmune disorders, Multiple sclerosis, Platelet defects/Platelet aggregation, Renal dysplasia, Rheumatoid arthritis, Thrombosis/Cardiac fibrosis, Vascular defects

Cardiovascular Experimental allergic encephalomyelitis, Induced rheumatoid arthritis, Oncology, Transplantation

Heart failure, Nephropathy, Salt-sensitive hypertension, Stroke

Adjuvant-induced arthritis, Immunology, Inflammation

Audiogenic seizures, Progressive hearing loss

Immunodeficiency, Peripheral neuropathy

Bipolar disorder, Neuronal growth and transport studies, Schizophrenia

Cre Tool for conditional expression or deletion in dopaminergic neurons, DREDD, Expression/knockout of floxed genes, Optogenetics

Auditory Studies

Analgesia, Cannabinoids, Neuroscience, Nociception, Pain

Autism (ASD), Fragile X syndrome, Neuroscience

Transgenic model development

Autism (ASD), Epilepsy, Neuroscience, Prader-Willi syndrome

Hibernation, Hypercholesterolemia, Syrian Hamster Embryo (SHE) Cell Transformation Assay

Alzheimer's disease, Dopaminergic cell toxicity, Neuroscience

Alzheimer's disease, Dopaminergic cell toxicity, Neuroscience

Neurodegenerative diseases

General studies, Neurology, Oncology, Reproduction, Teratology, Toxicology

Cardiovascular, Infectious disease, COVID-19

Cardiovascular, Infectious disease, COVID-19

Infectious disease, COVID-19

Oncology, Infectious disease, COVID-19

Artery disease, Atherogenesis, Atherosclerosis- Cholesterol transportation, Hypertension, Insulin resistant, Lipoprotein, Metabolism (Triglyceride - Cholesterol), Obesity, Type II diabetes

Artery disease, Atherogenesis, Atherosclerosis, Diabetes, HypertensionInsulin resistance, Lipoprotein/Cholesterol transportation, Metabolism (Triglyceride/Cholesterol), Obesity, Type II diabetes

Adjuvant-induced arthritis

Asthma, Colitis, Crohn's disease, Immunology, Inflammation/Autoimmune disorders, Multiple sclerosis, Oncology, Platelet defects/Platelet aggregation, Renal dysplasia, Rheumatoid arthritis, Thrombosis/Cardiac fibrosis, Vascular defects

Behavior

Nutrition

Neuronal apoptosis, Neuroscience, Parkinson's disease

Neuronal apoptosis, Neuroscience, Parkinson's disease

Neuronal apoptosis

Blood brain barrier efflux, DMPK assay, Drug metabolism, Drug resistance, Drug transporter, Efficacy, Formulation drug-drug interactions, Neurotoxicology, PK-PD efflux assay

ADMET, Blood brain barrier efflux, DMPK assay, Drug metabolism, Drug resistance, Drug transporter, Efficacy, Formulation drug-drug interactions, Neurotoxicology, PK-PD efflux assay

Blood brain barrier efflux, DMPK assay, Drug metabolism, Drug resistance, Drug transporter, Efficacy, Formulation drug-drug interactions, Neurotoxicology, PK-PD efflux assay

Autism (ASD), Cognition, Neuroscience, Rett Syndrome

Autism (ASD), Autoimmune disorders, Neuroscience, Synaptic Plasticity

Anxiety, Autism (ASD), Cognition, Fragile X syndrome, Pain, Schizophrenia

ADMET, Drug metabolism, Drug resistance, Drug transporter, Studying excretion pathways in cancer

DMPKPK/PDFormulation, Drug transporter, Dubin-Johnson syndrome, Efficacy Drug-drug interactions, Efflux assays, Tissue distribution

Pain and neuroscience, Toxicology

Schizophrenia, Synaptic Plasticity

Asperger's syndrome, Autism (ASD), Synaptic Plasticity

Dermatology, Renal Studies

General purpose studies

General studies

Antibody production, Autoimmune disease, Immunology, Transplantation

Infectious disease, Toxicology

ADMET, Drug-drug interactions, Drug metabolism, Drug transporter, Hepatotoxicity

ADMET, Drug-drug interactions, Drug metabolism, Drug transporter, Hepatotoxicity

ADMET, Drug-drug interactions, Drug metabolism, Drug transporter, Hepatotoxicity

ADMET, Drug-drug interactions, Drug metabolism, Hepatotoxicity

Addiction, Analgesia, Neuroscience, Nociception, Pain

Autoimmune disease, Cancer, Hematopoiesis, Infectious disease, Oncology, Vaccine development, Xenografts

Analgesia, Neuronal apoptosis, Nociception, Pain

Dopaminergic cell toxicity

Dopaminergic cell toxicity

Cre Tool for conditional expression or deletion in PV+ neurons, Expression/knockout of floxed genes, Neuroscience, Optogenetics

Autoimmune disorders, Cell proliferation, Drug metabolism, Diabetes, Immunology, Inflammation, Lipid metabolism, Obesity, Wound healing, Xenobiotic

Cancer metastasis, Oncology, Tumor cell growth, Xenograft

Cancer, Neuroscience, Oncology

Cholestasis, Cytochrome p450 pathways, Drug metabolism, Hepatotoxicity, Xenobiotic

Cholestasis, Cytochrome p450 pathways, Drug metabolism, Hepatotoxicity, Xenobiotic

ADMET, Cholestasis, Cytochrome p450 pathways, Drug metabolism, Hepatotoxicity, Xenobiotic

Cancer metastasis, Immunology, Inflammation/Autoimmune disorders, Oncology, Thrombosis/Cardiac fibrosis, Vaccine development, Xenograft

Cancer metastasis, Hematopoieses, Immunology, Inflammation/Autoimmune disorders, Infectious disease, Thrombosis/Cardiac fibrosis, Vaccine development, Vascular defects, Xenograft

Cancer metastasis, Inflammation/Autoimmune disorders, Thrombosis/Cardiac fibrosis, Vaccine development, Vascular defects, Xenograft

Cancer metastasis, Immunology, Inflammation/Autoimmune disorders, Hematopoieses, Thrombosis/Cardiac fibrosis, Vascular defects, Xenograft

Cancer cell transplantation, Infectious disease

Autism (ASD), Neurodegenerative Disorders, Neuroscience

Accelerated senescence studies, Age-dependent disorders, Brain atrophy, Deficits in learning and memory, Emotional disorders Aging process, Geriatric pathogenesis, Hearing impairment, Hyperinflation of the lungs, Senile amyloidosis (apolipoprotein A-II), Senile osteoporosis

Teratology

Humanization applications, Imaging applications, Xenograft transplantation

Behavior, Immunology

Insulin resistant

Age-associated pathology, Cardiovascular, Immune response, Longevity, Memory, Metabolism, Motor skills, Neoplasia, Neurobiology, Osteoarthritis, Renal degeneration, Reproductive senescence, Vision and hearing

Cre Tool for conditional expression or deletion in SST+ neurons, Expression/knockout of floxed genes, Neuroscience, Optogenetics

Asthma, Colitis, Crohn's disease, Immunology, Inflammation/Autoimmune disorders, Multiple sclerosis, Oncology, Platelet defects/Platelet aggregation, Renal dysplasia, Rheumatoid arthritis, Thrombosis/Cardiac fibrosis, Vascular defects

Expression of td, Optogenetics, Tomato fluorescence when Cre-recombinase is introduced

General purpose

Cre Tool for conditional expression or deletion in Tph2+ neurons, Expression/knockout of floxed genes, Neuroscience, Optogenetics

Analgesia, Cannabinoids, Nociception, Pain, Thermoregulation

Cre Tool for conditional expression or deletion in Th+ neurons, DREADD, Expression/knockout of floxed genes, Optogenetics

Cre Tool for conditional expression or deletion in VGAT+ neurons, Expression/knockout of floxed genes, Neuroscience, Optogenetics

Cre Tool for conditional expression or deletion in VIP+ neurons, Expression/knockout of floxed genes, Neuroscience, Optogenetics

Immunology, Leukemia, Transplantation

Immunology, Inbred, normotensive control for SHR rat

Aging, Nutrition, Oncology, Teratology

Aging, General purpose model, Nutrition, Oncology, Teratology