Neurexin1-Nrxn1 knockout rats
HsdSage:SD-Nrxn1em1Sage
Strain
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Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
- Background strain: Sprague Dawley
- Biallelic 726 bp deletion within Nrxn1 gene
- Decreased transport of endogenous glutathione
- Homozygous knockouts display total loss of protein via Western blot
- Hyperbilirubinemia
Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous as live colony
This model contains a biallelic deletion of the Neurexin 1 gene (Nrxn1). Mutations in Nrxn1 have been associated with autism spectrum disorders (ASD) and this model is useful for understanding the role of neurexins in the development of ASD.
Origin: The Neurexin1 - Nrxn1 KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.
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For pricing information, please contact us using the phone number above.
Research use and related publications
- Autism
- Neuroscience
- Schizophrenia
- Synaptic Plasticity
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