B-NDG B2m double knockout plus mice

• Background strain: NOD.SCID 

Availability: Live colony (limited)
Zygosity genotype: Homozygous

The B-NDG B2m model is a double knockout mouse with an ultra-immunodeficient phenotype. The model was generated by Biocytogen by deleting the IL2rg gene from NOD-scid mice. Prkdc (protein kinase DNA-activated catalytic) null scid mutation is characterized by significantly deficient of functional T cells and B cells.

The Common gamma chain gene (IL2RG) deletion results in a lack of functional receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21, which results in the lack of functional NK cells.

The B2m gene is fused in the FcRn gene while the endogenous murine B2m gene is knocked out. This mouse combines the B-NDG mouse background with the absence of the MHC class I molecule β2m and shows no difference in the metabolism of IgG drugs in mice compared with wild-type mice. This model is effective against GVHD effects.

Origin:

The model was developed by Biocytogen. Envigo licensed the mouse model from Biocytogen in 2021, where the model had been maintained. The model is maintained and distributed by Envigo, acquired by Inotiv in 2021.

Diet and Husbandry:
Our rodent models are raised and maintained on Teklad diet, bedding, and enrichment products:

• Diet: Teklad Global Rodent Diet
• Bedding: Teklad Contact Bedding (U.S. only)
• Enrichment: Teklad Enrichment Products (U.S. only)

Model Support Services:
Inotiv offers related model support services to deliver research-ready models to your facility:

• Surgical Services
• Preconditioning Services
• Aging Services
• Contract Breeding Services
• Biospecimen Services

• United States - 239 - Livermore, CA

Available regions:

II. Non-Profit (Academic) Male Order code: 405 - US

II. Non-Profit (Academic) Female Order code: 405 - US

I. For-Profit (Commercial) Male Order code: 405 - US

I. For-Profit (Commercial) Female Order code: 405 - US

• Model information sheet