BSEP knockout rats
HsdSage:SD-Abcb11em1Sage
Strain
Location
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Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
- Background strain: Sprague Dawley
- Biallelic 8bp deletion within the Abcb11 gene
- Homozygous knockout rats display total loss of protein via Western blot
Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous as live colony
Abcb11 encodes the bile salt export pump (BSEP) found in the liver. BSEP is critical in the secretion of bile by releasing bile salts from the liver, and mutations in BSEP have been associated with progressive familial intrahepatic cholestasis in humans.
Drug induced liver injury is an important clinical issue, and may result from inhibition of BSEP. Chemical inhibition of BSEP can lead to decreased bile flow and buildup of bile salts in hepatocytes, resulting in toxicity. Understanding the potential of BSEP inhibition by drug candidates is thus of significant importance for drug discovery and development. This model is useful in studying impairment of bile secretion.
Origin: The BSEP KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.
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For pricing information, please contact us using the phone number above.
Research use and related publications
- ADMET
- Cholestasis
- Drug-drug interactions
- Drug-induced cholestasis (DIC)
- Drug metabolism
- Drug transporter
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