Mrp2 knockout rats
HsdSage:SD-Abcc2em1Sage
Strain
Location
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Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
- Background strain: Sprague Dawley
- Biallelic 726 bp deletion within Abcc2 gene
- Decreased transport of endogenous glutathione
- Homozygous knockout rats display total loss of protein via Western blot
- Hyperbilirubinemia
Availability: Cryopreserved as heterozygous embryos
Zygosity: Homozygous as live colony
Homozygous Mrp2 null rats display compromised biliary excretion and hyperbilirubinemia. This results in accumulation of glutathione-conjugated drugs in the liver.
Mrp2 is expressed in the liver and functions in biliary transport. The gene's substrates include anticancer compounds such as vinblastine, enabling it to confer multiple drug resistance to tumor cells. This model is useful for forumational, efficacy, tissue distribution, and DMPK assays
Origin: The Mrp2 KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.
Available regions:
For pricing information, please contact us using the phone number above.
Research use and related publications
- ADMET
- Tissue distribution
- DMPKPK/PDFormulation
- Drug transporter
- Dubin-Johnson syndrome
- Efficacy Drug-drug interactions
- Efflux assays
- Tissue distribution
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