Inotiv

Mrp1 knockout rats

HsdSage:SD-Abcc1aem1Sage
Strain
HsdSage:SD-Abcc1aem1Sage
Location
U.S. (Cryopreserved)
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+1 800 793 7287
Description
Pricing
Technical resources
Cryopreserved

Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
  • Background strain: Sprague Dawley
  • Decreased transport of glutatione-conjugated substrates
  • Homozygous knockout rats display total loss of protein via Western blot
  • Increased bioavailability of specific substrate Fluorescein


Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous as live colony

This model contains a 43 base pair bi-allelic deletion within the Mrp1 gene, synonym Abcc1a (ATP-binding cassette, sub-family C [CFTR/MRP], member 1a), encoding an ATP-dependent drug transporter.

Mrp1 is a multispecific organic anion transporter that extrudes glutathione-, glucouronide- or sulfate-conjugated substrates (steroids, leukotrienes, etc.), as well as xenobiotic drugs out of cells. Mrp1 can confer multiple drug resistance to tumor cells. Absence of Mrp1 creates a functional deficiency in the cellular transport of some substrates and results in compromised inflammatory response, making this model useful for studying drug transport in inflammatory stimulus response and chemotherapeutic agents.


Origin: The Mrp1 KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.

Available regions:

Asia-Pacific Austria Baltic states Belgium East Europe France Germany Ireland Italy Portugal Scandinavia Spain Switzerland The Netherlands United States United Kingdom Other regions

For pricing information, please contact us using the phone number above.

 
Research use and related publications
  • ADMET
  • Drug metabolism
  • Drug resistance
  • Drug transporter
  • Studying excretion pathways in cancer

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