Gabrb3 knockout rats
HsdSage:SD-Gabrb3em1Sage
Strain
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Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
- This model was created in collaboration with Autism Speaks
- 8 bp deletion in Gabrb3
- Background Strain: Sprague-Dawley
Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous as live colony
Generated in conjunction with Autism Speaks, this knockout rat model possesses an 8 bp deletion in the gamma-aminobutyric acid type A receptor beta3 subunit protein encoded by the Gabrb3 gene. Gabrb3 has been associated with several disorders including Prader-Willi syndrome, epilepsy and autism.
Origin:
The Gabrb3 Knockout Rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.
Available regions:
For pricing information, please contact us using the phone number above.
Research use and related publications
- Autism (ASD)
- Epilepsy
- Neuroscience
- Prader-Willi syndrome
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