Oprm1 knockout rats
HsdSage:SD-Oprm1em1Sage
Strain
Location
Order Today
Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
- 11 base pair deletion in exon 2
- Background strain: Sprague Dawley
- Early stop codon in exon 3
Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous as live colony
This model possesses an 11 base pair deletion in exon 2 of the Oprm1 gene, leading to an early stop codon in exon 3. Oprm1 encodes the mu opioid receptor 1 (MOR), the major target of most clinically used opioids. This model is useful for applications investigating nociception, and is particularly useful for discrimination among opioid receptor subtypes.
Origin: The Oprm1 KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.
Available regions:
For pricing information, please contact us using the phone number above.
Research use and related publications
- Addiction
- Analgesia
- Neuroscience
- Nociception
- Pain
2025 Product guide
Receive a copy of our current research models and services product guide.
SCIENTIFIC
INSIGHTS
Keep up-to-date with the latest industry thinking and scientific insights
Explore today
More than 90 years of working together, to build a healthier and safer world
Explore our history
Subscribe to updates from Inotiv
Sign up and you’ll receive the latest updates that matter to you, delivered straight to your inbox.
