Trpv1 knockout rats
HsdSage:SD-Trpv1em1Sage
Strain
Location
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- Background strain: Sprague Dawley
- Homozygous knockout rats exhibit complete loss of Trpv1 protein
- Trpv1 knockout rats show hyposensitivity to thermal pain via hot plate assay
Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous as live colony
This model contains a biallelic deletion of the Trpv1 gene, encoding for the transient receptor potential cation channel subfamily V member 1. Capsaicin, the component in chili peppers that makes them hot, is an exogenous ligand for Trpv1. Trpv1 is also activated by heat.
Trpv1 is a non-selective cation channel, activated by a range of stimuli including capsaicin, cannabinoids, and heat. Trpv1 activation results in the sensation of pain as well as the lowering of body temperature. Trpv1 antagonists are being pursued as potential novel analgesics.
Origin: The Trpv1 KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.
Available regions:
For pricing information, please contact us using the phone number above.
Research use and related publications
- Neuroscience
- Analgesia
- Cannabinoids
- Nociception
- Pain
- Thermoregulation
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