Lrrk1 knockout rats
HsdSage:LE-Lrrk1em1Sage
Strain
Location
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Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
- Background strain: Long Evans Hooded
Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous as live colony
Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Lrrk1 gene, encoding for the leucine-rich repeat kinase 1. This model is useful in understanding Lrrk1 biology.
Origin: The Lrrk1 KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.
Available regions:
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Research use and related publications
- Neuronal apoptosis
- Neuroscience
- Parkinson's disease
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