Cox2 knockout rats
HsdSage:SD-Cox2em1Sage
Strain
Location
Order Today
Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
- Homozygous knockouts display loss of COX2 protein via Western blot
- Background Strain: Sprague-Dawley
Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous
COX2 is one of the isoenzymes from Cyclooxygenase (COX) family and is responsible for inflammation and pain. Several pain relieving drugs such as Celecoxib and Rofecoxib selectively target COX2.
Origin:
The Cox2 Knockout Rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.
Available regions:
For pricing information, please contact us using the phone number above.
Research use and related publications
- Asthma
- Colitis
- Crohn's disease
- Immunology
- Inflammation/Autoimmune disorders
- Multiple sclerosis
- Platelet defects/Platelet aggregation
- Renal dysplasia
- Rheumatoid arthritis
- Thrombosis/Cardiac fibrosis
- Vascular defects
2025 Product guide
Receive a copy of our current research models and services product guide.
SCIENTIFIC
INSIGHTS
Keep up-to-date with the latest industry thinking and scientific insights
Explore today
More than 90 years of working together, to build a healthier and safer world
Explore our history
Subscribe to updates from Inotiv
Sign up and you’ll receive the latest updates that matter to you, delivered straight to your inbox.
