Inotiv

AHR knockout rats

HsdSage:SD-Ahrem1Sage
Strain
HsdSage:SD-Ahrem1Sage
Location
U.S. (Cryopreserved)
Order Today
+1 800 793 7287
Description
Pricing
Technical resources
Cryopreserved

Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
  • Background strain: Sprague Dawley
  • Biallelic deletion of Ahr

Availability: Cryopreserved as heterozygous embryos
Zygosity: Homozygous as live colony

AHR is involved in the induction of cytochrome p450s and is abundantly expressed in the liver and intestine. This model is useful for studying metabolism of xenobiotic compounds and hepatotoxicity.


Origin:

The AHR KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.

Available regions:

Asia-Pacific Austria Baltic states Belgium East Europe France Germany Ireland Italy Portugal Scandinavia Spain Switzerland The Netherlands United States United Kingdom Other regions

For pricing information, please contact us using the phone number above.

 
Research use and related publications
  • ADMET
  • Obesity
  • Cholestasis
  • Cytochrome p450 pathways
  • Drug metabolism
  • Hepatotoxicity
  • Xenobiotic

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