Ppara knockout rats
HsdSage:SD-Pparaem1Sage
Strain
Location
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- Background strain: Sprague Dawley
- Homozygous knockout rats display total loss of protein via Western blot
Availability: Cryopreserved as heterozygous embryos
Zygosity: Homozygous as live colony
This model contains a bi-allelic deletion within the peroxisome proliferator-activated receptor alpha gene (Ppara).
Ppara (peroxisome proliferator-activated receptor alpha gene) is a ligand activated nuclear receptor, known to be activated by free fatty acids and their derivatives. Besides the studying of lipid metabolism and diabetes, Ppar-alpha affect the expression of target genes involved in cell proliferation, cell differentiation, and in immune and inflammation responses.
Origin: The Ppara KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.
Available regions:
For pricing information, please contact us using the phone number above.
Research use and related publications
- ADMET
- Autoimmune disorders
- Cell proliferation
- Drug metabolism
- Diabetes
- Immunology
- Inflammation
- Lipid metabolism
- Obesity
- Wound healing
- Xenobiotic
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