Parvalbumin-Cre knockin rats

• Background strain: Long Evans Hooded
• Cre recombinase driven by endogenous Paravalbumin promoter
• No observed ectopic expression of cre
• Targeted insertion eliminates possible gene disruption that may occur in random insertion technologies such as BAC

Availability: Live colony
Zygosity genotype: Homozygous

This model expresses cre-recombinase under the control of the endogenous paravalbumin (Pvalb) promoter enabling specific expression in inhibitory neurons. This model possesses a targeted insertion of (IRES)-cre immediately after the translational stop in the open reading frame of Pvalb. The Paravalbumin-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines.

Origin:

The Parvalbumin-Cre KI rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.

Diet and Husbandry:
Our rodent models are raised and maintained on Teklad diet, bedding, and enrichment products:

• Diet: Teklad Global Rodent Diet
• Bedding: Teklad Contact Bedding (U.S. only)
• Enrichment: Teklad Enrichment Products (U.S. only)

Model Support Services:
Inotiv offers related model support services to deliver research-ready models to your facility:

• Surgical Services
• Preconditioning Services
• Aging Services
• Contract Breeding Services
• Biospecimen Services

• United States - Building 410 Denver, PA

Available regions:

For pricing information, please contact us using the phone number above.

• Model information sheet