Park2 Parkin knockout rats

• Background strain: Long Evans Hooded
• Homozygous knockout rats display total loss of protein via Western blot
• Park2 knockout rats show normal motor performance on rotarod

Availability: Live colony
Zygosity genotype: Homozygous as live colony

Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Park2 (Parkinson disease [autosomal recessive, juvenile] 2) gene, encoding for the protein Parkin. Mutations in Parkin have been linked to early-onset Parkinson's disease (PD), making this model useful to further understand the role of Parkin in PD.

In humans, loss of function of Park2 leads to a form of familial Parkinson's disease. The Parkin protein is part of the ubiquitin-proteasomal enzyme pathway and may help degrade other proteins that are toxic to neurons. Roughly 20% of patients with Parkinson's disease onset before age 40 have mutations within Park2, making this an ideal model for the study of Parkinson's disease.

Origin:

The Park2 Parkin KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.

Diet and Husbandry:
Our rodent models are raised and maintained on Teklad diet, bedding, and enrichment products:

• Diet: Teklad Global Rodent Diet
• Bedding: Teklad Contact Bedding (U.S. only)
• Enrichment: Teklad Enrichment Products (U.S. only)

Model Support Services:
Inotiv offers related model support services to deliver research-ready models to your facility:

• Surgical Services
• Preconditioning Services
• Aging Services
• Contract Breeding Services
• Biospecimen Services

Available regions:

For pricing information, please contact us using the phone number above.

• Model information sheet