Inotiv

Athymic nude mice

Strains
Hsd:Athymic Nude-Foxn1nu Hsd:Athymic Nude-Foxn1nu/Foxn1+

The Unique Traits of Athymic Nude Mice

athymic-nude-mouseAthymic nude mice are popular in preclinical research because of their unique immunodeficient characteristics. These mice lack functional T cells, making them unable to mount a full immune response against a transplanted tissue or foreign material. The use of athymic nude mice is advantageous over other rodent models because they have an extended lifespan, better tumor take rates, and are less prone to infections. While they are less fragile than many other immunodeficient mouse models, they do require more specialized care and housing than immunocompetent models. These traits make this mouse model a valuable tool for researchers who may be studying the immune system, the development of tumors, or cancer disease progression.

Discover the perfect athymic nude mice for your research. Explore detailed information, technical data, and pricing on our dedicated strain pages for:

The Origin of Athymic Mice

The “nu” mutation was discovered in 1962 in a closed outbred stock of albino mice in the Virus Laboratory, Ruchill Hospital, Glasgow, Scotland. The mutation is an autosomal recessive mutation (Foxn1 gene) and is responsible for their lack of functional T cells, which led to the development of a strain called "nude" mice. Harlan, now Inotiv, obtained the athymic nude mouse model from the National Cancer Institute, National Institutes of Health, Maryland.

How Athymic Nude Mice Contribute to Medical Research

Athymic nude mice are also versatile research models that can be used for the discovery and development of various therapeutic interventions. At Inotiv, these mice are used in research services such as oncology studies, immunology studies, transplantation studies, pharmacokinetic and toxicology analysis, disease modeling and drug efficacy testing.

Future Prospects: Next Steps in Athymic Nude Mouse Research

Athymic nude mice have become a vital research model for preclinical research because of their unique immunodeficient nature, versatility, and easy adaptability compared to other animal models. These mice make it possible to conduct research into the development of new therapies, vaccines, and drugs that can save lives.

Characteristics

  • B-cells function normal
  • Coat: Albino
  • Dysfunctional rudimentary thymus
  • Litter Average: 7
  • No generation of cytotoxic effector cells
  • No graft versus host response
  • Phenotypically hairless (sparse, intermittent hair growth possible)
  • T-cell deficient
  • The nu allele on chromosome 11 is an autosomal recessive mutation

Athymic nude mice publications

Autoimmune disease
Gene therapy
General studies
Immunology
Oncology
Surgical
Transplantation
Tumor cell growth
Tumor growth

Autoimmune disease

Kalliokoski, S., Caja, S., Frias, R., Laurila, K., Koskinen, O., Niemela, O., . . . Lindfors, K. (2015), Injection of celiac disease patient sera or immunoglobulins to mice reproduces a condition mimicking early developing celiac disease., Journal of Molecular Medicine (Berlin, Germany), 93(1), 51-62. doi:10.1007/s00109-014-1204-8 [doi]

Gene therapy

Qiu M, Li G, Wang P, Li X, Lai F, Luo R, Liu B, Lin J., aarF domain containing kinase 5 gene promotes invasion and migration of lung cancer cells through ADCK5-SOX9-PTTG1 pathway, Exp Cell Res. 2020 Jul 1;392(1):112002. doi: 10.1016/j.yexcr.2020.112002. Epub 2020 Apr 8.
Lampe, J., Bossow, S., Weiland, T., Smirnow, I., Lehmann, R., Neubert, W., . . . Lauer, U. M. (2013)., An armed oncolytic measles vaccine virus eliminates human hepatoma cells independently of apoptosis., Gene Therapy, 20(11), 1033-1041. doi:10.1038/gt.2013.28 [doi]
Tiwari A, Iida M, Kosnopfel C, Abbariki M, Menegakis A, Fehrenbacher B, Maier J, Schaller M, Brucker SY, Wheeler DL, Harari PM, Rothbauer U, Schittek B, Zips D, Toulany M., Blocking Y-Box Binding Protein-1 through Simultaneous Targeting of PI3K and MAPK in Triple Negative Breast Cancers, Cancers (Basel). 2020 Sep 29;12(10):2795. doi: 10.3390/cancers12102795.
Feichtinger, G. A., Hacobian, A., Hofmann, A. T., Wassermann, K., Zimmermann, A., van Griensven, M., & Redl, H. (2014)., Constitutive and inducible co-expression systems for non-viral osteoinductive gene therapy., European Cells & Materials, 27, 166-84; discussion 184. doi:vol027a13 [pii]
McCarthy GA, Di Niro R, Finan JM, Jain A, Guo Y, Wyatt CR, Guimaraes AR, Waugh TA, Keith D, Morgan TK, Sears RC, Brody JR., Deletion of the mRNA stability factor ELAVL1 (HuR) in pancreatic cancer cells disrupts the tumor microenvironment integrity., NAR Cancer. 2023 Apr 19;5(2):zcad016. doi: 10.1093/narcan/zcad016. eCollection 2023 Jun.
Gentschev, I., Muller, M., Adelfinger, M., Weibel, S., Grummt, F., Zimmermann, M., . . . Szalay, A. A. (2011)., Efficient colonization and therapy of human hepatocellular carcinoma (HCC) using the oncolytic vaccinia virus strain GLV-1h68., PloS One, 6(7), e22069. doi:10.1371/journal.pone.0022069 [doi]
Arruabarrena-Aristorena A, Maag JLV, Kittane S, Cai Y, Karthaus WR, Ladewig E, Park J, Kannan S, Ferrando L, Cocco E, Ho SY, Tan DS, Sallaku M, Wu F, Acevedo B, Selenica P, Ross DS, Witkin M, Sawyers CL, Reis-Filho JS, Verma CS, Jauch R, Koche R, Baselga J, Razavi P, Toska E, Scaltriti M., FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer, Cancer Cell. 2020 Oct 12;38(4):534-550.e9. doi: 10.1016/j.ccell.2020.08.003. Epub 2020 Sep 3.
Yu, L., Liang, Y., Cao, X., Wang, X., Gao, H., Lin, S. Y., . . . Li, K. (2017), Identification of MYST3 as a novel epigenetic activator of ERalpha frequently amplified in breast cancer., Oncogene, 36(20), 2910-2918. doi:10.1038/onc.2016.433 [doi]
Unzu, C., Melero, I., Morales-Kastresana, A., Sampedro, A., Serrano-Mendioroz, I., Azpilikueta, A., . . . Fontanellas, A. (2014), Innate functions of immunoglobulin M lessen liver gene transfer with helper-dependent adenovirus, PloS One, 9(1), e85432. doi:10.1371/journal.pone.0085432 [doi]
Dowaidar, M., Abdelhamid, H. N., Hallbrink, M., Freimann, K., Kurrikoff, K., Zou, X., & Langel, U. (2017)., Magnetic nanoparticle assisted self-assembly of cell penetrating peptides-oligonucleotides complexes for gene delivery, Scientific Reports, 7(1), 9159-017-09803-z. doi:10.1038/s41598-017-09803-z [doi]
Dinami R, Pompili L, Petti E, Porru M, D'Angelo C, Di Vito S, Rizzo A, Campani V, De Rosa G, Bruna A, Serra V, Mano M, Giacca M, Leonetti C, Ciliberto G, Tarsounas M, Stoppacciaro A, Schoeftner S, Biroccio A., MiR-182-3p targets TRF2 and impairs tumor growth of triple-negative breast cancer., EMBO Mol Med. 2023 Jan 11;15(1):e16033. doi: 10.15252/emmm.202216033. Epub 2022 Nov 25.
Kim SS, Doherty C, Moghe M, Rait A, Pirollo KF, Harford JB, Chang EH., Nanomedicine-Based Gene Delivery for a Truncated Tumor Suppressor RB94 Promotes Lung Cancer Immunity, Cancers (Basel). 2022 Oct 18;14(20):5092. doi: 10.3390/cancers14205092.
Ady, J. W., Johnsen, C., Mojica, K., Heffner, J., Love, D., Pugalenthi, A., . . . Fong, Y. (2015)., Oncolytic gene therapy with recombinant vaccinia strain GLV-2b372 efficiently kills hepatocellular carcinoma., Surgery, 158(2), 331-338. doi:10.1016/j.surg.2015.03.044 [doi]
Veiman, K. L., Kunnapuu, K., Lehto, T., Kiisholts, K., Parn, K., Langel, U., & Kurrikoff, K. (2015)., PEG shielded MMP sensitive CPPs for efficient and tumor specific gene delivery in vivo., Journal of Controlled Release : Official Journal of the Controlled Release Society, 209, 238-247. doi:10.1016/j.jconrel.2015.04.038 [doi]
Croessmann, S., Wong, H. Y., Zabransky, D. J., Chu, D., Rosen, D. M., Cidado, J., . . . Park, B. H. (2017)., PIK3CA mutations and TP53 alterations cooperate to increase cancerous phenotypes and tumor heterogeneity., Breast Cancer Research and Treatment, 162(3), 451-464. doi:10.1007/s10549-017-4147-2 [doi]
Hollevoet, K., De Smidt, E., Geukens, N., & Declerck, P. (2018), Prolonged in vivo expression and anti-tumor response of DNA-based anti-HER2 antibodies, Oncotarget, 9(17), 13623-13636. doi:10.18632/oncotarget.24426 [doi]
Kaliberov, S. A., Kaliberova, L. N., Yan, H., Kapoor, V., & Hallahan, D. E. (2016)., Retargeted adenoviruses for radiation-guided gene delivery., Cancer Gene Therapy, 23(9), 303-314. doi:10.1038/cgt.2016.32 [doi]
Shapira, S., Shapira, A., Kazanov, D., Hevroni, G., Kraus, S., & Arber, N. (2017)., Selective eradication of cancer cells by delivery of adenovirus-based toxins., Oncotarget, 8(24), 38581-38591. doi:10.18632/oncotarget.16934 [doi]
Anders, N. M., Liu, J., Wanjiku, T., Giovinazzo, H., Zhou, J., Vaghasia, A., . . . Rudek, M. A. (2016)., Simultaneous quantitative determination of 5-aza-2'-deoxycytidine genomic incorporation and DNA demethylation by liquid chromatography tandem mass spectrometry as exposure-response measures of nucleoside analog DNA methyltransferase inhibitors, Journal of Chromatography.B, Analytical Technologies in the Biomedical and Life Sciences, 1022, 38-45. doi:S1570-0232(16)30178-7 [pii]
Feichtinger, G. A., Hofmann, A. T., Slezak, P., Schuetzenberger, S., Kaipel, M., Schwartz, E., . . . Redl, H. (2014)., Sonoporation increases therapeutic efficacy of inducible and constitutive BMP2/7 in vivo gene delivery., Human Gene Therapy Methods, 25(1), 57-71. doi:10.1089/hgtb.2013.113 [doi]
Abel, T., El Filali, E., Waern, J., Schneider, I. C., Yuan, Q., Munch, R. C., . . . Buchholz, C. J. (2013)., Specific gene delivery to liver sinusoidal and artery endothelial cells, Blood, 122(12), 2030-2038. doi:10.1182/blood-2012-11-468579 [doi]
Hou R, Yu Y, Sluter MN, Li L, Hao J, Fang J, Yang J, Jiang J., Targeting EP2 receptor with multifaceted mechanisms for high-risk neuroblastoma, Cell Rep. 2022 Jun 21;39(12):111000. doi: 10.1016/j.celrep.2022.111000.
Chatterjee S, Naidu GS, Hazan-Halevy I, Grobe H, Ezra A, Sharma P, Goldsmith M, Ramishetti S, Sprinzak D, Zaidel-Bar R, Peer D., Therapeutic gene silencing of CKAP5 leads to lethality in genetically unstable cancer cells., Sci Adv. 2023 Apr 5;9(14):eade4800. doi: 10.1126/sciadv.ade4800. Epub 2023 Apr 5.
Presutti, D., Ceccarelli, M., Micheli, L., Papoff, G., Santini, S., Samperna, S., . . . Tirone, F. (2018)., Tis21-gene therapy inhibits medulloblastoma growth in a murine allograft model., PloS One, 13(3), e0194206. doi:10.1371/journal.pone.0194206 [doi]
Nomikou, N., Feichtinger, G. A., Saha, S., Nuernberger, S., Heimel, P., Redl, H., & McHale, A. P. (2018)., Ultrasound-responsive gene-activated matrices for osteogenic gene therapy using matrix-assisted sonoporation., Journal of Tissue Engineering and Regenerative Medicine, 12(1), e250-e260. doi:10.1002/term.2406 [doi]

General studies

Choi YH, Zhang C, Liu Z, Tu MJ, Yu AX, Yu AM., A Novel Integrated Pharmacokinetic-Pharmacodynamic Model to Evaluate Combination Therapy and Determine In Vivo Synergism, J Pharmacol Exp Ther. 2021 Jun;377(3):305-315. doi: 10.1124/jpet.121.000584. Epub 2021 Mar 12.
Landgraf, L., Christner, C., Storck, W., Schick, I., Krumbein, I., Dahring, H., . . . Hilger, I. (2015), A plasma protein corona enhances the biocompatibility of Au@Fe3O4 janus particles, Biomaterials, 68, 77-88. doi:10.1016/j.biomaterials.2015.07.049 [doi]
Cook Sangar ML, Girard EJ, Hopping G, Yin C, Pakiam F, Brusniak MY, Nguyen E, Ruff R, Gewe MM, Byrnes-Blake K, Nairn NW, Miller DM, Mehlin C, Strand AD, Mhyre AJ, Correnti CE, Strong RK, Simon JA, Olson JM., A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure, Sci Transl Med. 2020 Mar 4;12(533):eaay1041. doi: 10.1126/scitranslmed.aay1041.
Crook ZR, Girard E, Sevilla GP, Merrill M, Friend D, Rupert PB, Pakiam F, Nguyen E, Yin C, Ruff RO, Hopping G, Strand AD, Finton KAK, Coxon M, Mhyre AJ, Strong RK, Olson JM., A TfR-Binding Cystine-Dense Peptide Promotes Blood-Brain Barrier Penetration of Bioactive Molecules, J Mol Biol. 2020 Jun 26;432(14):3989-4009. doi: 10.1016/j.jmb.2020.04.002. Epub 2020 Apr 15.
Joshi S, Montes de Oca I, Maghrabi A, Lopez-Yang C, Quiroz-Olvera J, Garcia CA, Jarajapu YPR., ACE2 gene transfer ameliorates vasoreparative dysfunction in CD34+ cells derived from diabetic older adults, Clin Sci (Lond). 2021 Jan 29;135(2):367-385. doi: 10.1042/CS20201133.
Crum RJ, Capella-Monsonís H, Chang J, Dewey MJ, Kolich BD, Hall KT, El-Mossier SO, Nascari DG, Hussey GS, Badylak SF., Biocompatibility and biodistribution of matrix-bound nanovesicles in vitro and in vivo, Acta Biomater. 2023 Jan 1;155:113-122. doi: 10.1016/j.actbio.2022.11.026. Epub 2022 Nov 22.
Talele S, Zhang W, Chen J, Gupta SK, Burgenske DM, Sarkaria JN, Elmquist WF., Central Nervous System Distribution of the Ataxia-Telangiectasia Mutated Kinase Inhibitor AZD1390: Implications for the Treatment of Brain Tumors, J Pharmacol Exp Ther. 2022 Oct;383(1):91-102. doi: 10.1124/jpet.122.001230. Epub 2022 Aug 5.
Das, S., Haedicke, K., & Grimm, J. (2018)., Cerenkov-activated sticky tag for in vivo fluorescence imaging., Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine, 59(1), 58-65. doi:10.2967/jnumed.117.198549 [doi]
Gaffron F, Tilch A, Grüttner C, Kowalski A, Kramer M, Teichgräber U, Hilger AI., Challenges in Tracking of Fluorochrome-Labelled Nanoparticles in Mice via Whole Body NIRF Imaging, Nanomaterials (Basel). 2020 Mar 24;10(3):596. doi: 10.3390/nano10030596.
Rahman, C. V., Ben-David, D., Dhillon, A., Kuhn, G., Gould, T. W., Muller, R., . . . Livne, E. (2014)., Controlled release of BMP-2 from a sintered polymer scaffold enhances bone repair in a mouse calvarial defect model., Journal of Tissue Engineering and Regenerative Medicine, 8(1), 59-66. doi:10.1002/term.1497 [doi]
Deng H, Qiao H, Dai Q, Ma C., Deep learning in photoacoustic imaging: a review, J Biomed Opt. 2021 Apr;26(4):040901. doi: 10.1117/1.JBO.26.4.040901.
Andleeb F, Katta N, Gruslova A, Muralidharan B, Estrada A, McElroy AB, Ullah H, Brenner AJ, Milner TE., Differentiation of Brain Tumor Microvasculature From Normal Vessels Using Optical Coherence Angiography, Lasers Surg Med. 2021 Jun 15. doi: 10.1002/lsm.23446. Online ahead of print.
Altshuler A, Amitai-Lange A, Tarazi N, Dey S, Strinkovsky L, Hadad-Porat S, Bhattacharya S, Nasser W, Imeri J, Ben-David G, Abboud-Jarrous G, Tiosano B, Berkowitz E, Karin N, Savir Y, Shalom-Feuerstein R., Discrete limbal epithelial stem cell populations mediate corneal homeostasis and wound healing, Cell Stem Cell. 2021 Jul 1;28(7):1248-1261.e8. doi: 10.1016/j.stem.2021.04.003. Epub 2021 May 12.
Netser S, Meyer A, Magalnik H, Zylbertal A, de la Zerda SH, Briller M, Bizer A, Grinevich V, Wagner S., Distinct dynamics of social motivation drive differential social behavior in laboratory rat and mouse strains, Nat Commun. 2020 Nov 20;11(1):5908. doi: 10.1038/s41467-020-19569-0.
Manuel R, Lima MS, Dilly S, Daunay S, Abbe P, Pramil E, Solier S, Guillaumond F, Tubiana SS, Escargueil A, Pęgas Henriques JA, Ferrand N, Erdelmeier I, Boucher JL, Bertho G, Agranat I, Rocchi S, Sabbah M, Slama Schwok A., Distinction between 2'- and 3'-Phosphate Isomers of a Fluorescent NADPH Analogue Led to Strong Inhibition of Cancer Cells Migration, Antioxidants (Basel). 2021 May 4;10(5):723. doi: 10.3390/antiox10050723.
Robin J, Ozbek A, Reiss M, Dean-Ben XL, Razansky D., Dual-Mode Volumetric Photoacoustic and Contrast Enhanced Ultrasound Imaging with Spherical Matrix Arrays, IEEE Trans Med Imaging. 2021 Nov 4;PP. doi: 10.1109/TMI.2021.3125398. Online ahead of print.
Kim, H. J., Park, S. S., Oh, S. Y., Kim, H., Kweon, O. K., Woo, H. M., & Kim, W. H. (2012), Effect of acellular dermal matrix as a delivery carrier of adipose-derived mesenchymal stem cells on bone regeneration., Journal of Biomedical Materials Research.Part B, Applied Biomaterials, 100(6), 1645-1653. doi:10.1002/jbm.b.32733 [doi]
Frees, S., Bidnur, S., Metcalfe, M., Raven, P., Chavez-Munoz, C., Moskalev, I., . . . So, A. (2016), Effect of contrast media on urinary cytopathology specimens., Canadian Urological Association Journal = Journal De l'Association Des Urologues Du Canada, 10(7-8), 228-233. doi:10.5489/cuaj.3874 [doi]
Floyd RJ, Ricart Arbona RJ, Carrasco SE, Lipman NS., Examination of Horizontal Transmission of Nippostrongylus brasiliensis in Mice to Assess Biosecurity Risks., J Am Assoc Lab Anim Sci. 2023 May 1;62(3):243-253. doi: 10.30802/AALAS-JAALAS-23-000004. Epub 2023 May 1.
Luengo Y, Díaz-Riascos ZV, García-Soriano D, Teran FJ, Artés-Ibáñez EJ, Ibarrola O, Somoza Á, Miranda R, Schwartz S Jr, Abasolo I, Salas G., Fine Control of In Vivo Magnetic Hyperthermia Using Iron Oxide Nanoparticles with Different Coatings and Degree of Aggregation, Pharmaceutics. 2022 Jul 22;14(8):1526. doi: 10.3390/pharmaceutics14081526.
Muñoz, Juan J; Tobajas, Esther; Juara, Sonia; Montero, Sara; Zapata, Agustín G;, FoxN1 mediates thymic cortex-medulla differentiation through modifying a developmental pattern based on epithelial tubulogenesis. Histochemistry and cell biology Vol.152, 2019, Histochemistry and cell biology Vol.152, 2019
van Rijn, S., Nilsson, J., Noske, D. P., Vandertop, W. P., Tannous, B. A., & Wurdinger, T. (2013), Functional multiplex reporter assay using tagged gaussia luciferase., Scientific Reports, 3, 1046. doi:10.1038/srep01046 [doi]
Klufa, Jörg; Bauer, Thomas; Hanson, Buck; Herbold, Craig; Starkl, Philipp; Lichtenberger, Beate; Srutkova, Dagmar; Schulz, Daniel; Vujic, Igor; Mohr, Thomas; Rappersberger, Klemens; Bodenmiller, Bernd; Kozakova, Hana; Knapp, Sylvia; Loy, Alexander; Sibilia, Maria;, Hair eruption initiates and commensal skin microbiota aggravate adverse events of anti-EGFR therapy, Science translational medicine Vol.11, 2019
Leporq, B., Lambert, S. A., Ronot, M., Boucenna, I., Colinart, P., Cauchy, F., . . . Van Beers, B. E. (2016)., Hepatic fat fraction and visceral adipose tissue fatty acid composition in mice: Quantification with 7.0T MRI., Quantification with 7.0T MRI. Magnetic Resonance in Medicine, 76(2), 510-518. doi:10.1002/mrm.25895 [doi]
Cheng Z, Li C, Khadria A, Zhang Y, Wang LV., High-gain and high-speed wavefront shaping through scattering media., Nat Photonics. 2023 Apr;17(4):299-305. doi: 10.1038/s41566-022-01142-4. Epub 2023 Jan 23.
Hernandez-Gonzalez F, Prats N, Ramponi V, López-Domínguez JA, Meyer K, Aguilera M, Muñoz Martín MI, Martínez D, Agusti A, Faner R, Sellarés J, Pietrocola F, Serrano M., Human senescent fibroblasts trigger progressive lung fibrosis in mice., Aging (Albany NY). 2023 Jul 1;15(14):6641-6657. doi: 10.18632/aging.204825. Epub 2023 Jul 1.
Ramis JM, Blasco-Ferrer M, Calvo J, Villa O, Cladera MM, Corbillo C, GayĂ  A, Monjo M., Improved physical and osteoinductive properties of demineralized bone matrix by gelatin methacryloyl formulation, J Tissue Eng Regen Med. 2020 Mar;14(3):475-485. doi: 10.1002/term.3012. Epub 2020 Feb 8.
Keyaerts, M., Remory, I., Caveliers, V., Breckpot, K., Bos, T. J., Poelaert, J., . . . Lahoutte, T. (2012)., Inhibition of firefly luciferase by general anesthetics: Effect on in vitro and in vivo bioluminescence imaging., PloS One, 7(1), e30061. doi:10.1371/journal.pone.0030061 [doi]
Li, R., Phillips, E., Wang, P., Goergen, C. J., & Cheng, J. X. (2015)., Label-free in vivo imaging of peripheral nerve by multispectral photoacoustic tomography., Journal of Biophotonics, 9999(9999), 10.1002/jbio.201500004. doi:10.1002/jbio.201500004 [doi]
Guduric-Fuchs J, Pedrini E, Lechner J, Chambers SEJ, O'Neill CL, Mendes Lopes de Melo J, Pathak V, Church RH, McKeown S, Bojdo J, Mcloughlin KJ, Stitt AW, Medina RJ., miR-130a activates the VEGFR2/STAT3/HIF1? axis to potentiate the vasoregenerative capacity of endothelial colony-forming cells in hypoxia, Mol Ther Nucleic Acids. 2021 Jan 20;23:968-981. doi: 10.1016/j.omtn.2021.01.015. eCollection 2021 Mar 5.
Mc Larney B, Hutter MA, Degtyaruk O, Deán-Ben XL, Razansky D., Monitoring of Stimulus Evoked Murine Somatosensory Cortex Hemodynamic Activity With Volumetric Multi-Spectral Optoacoustic Tomography, Front Neurosci. 2020 Jun 3;14:536. doi: 10.3389/fnins.2020.00536. eCollection 2020.
Kuehner F, Wong M, Straub E, Doorbar J, Iftner T, Roden RBS, Stubenrauch F., Mus musculus papillomavirus 1 E8^E2 represses expression of late protein E4 in basal-like keratinocytes via NCoR/SMRT-HDAC3 co-repressor complexes to enable wart formation in vivo., mBio. 2023 Aug 31;14(4):e0069623. doi: 10.1128/mbio.00696-23. Epub 2023 Jun 29.
Zhang M, Ye J, Xie Z, Yan Y, Wang J, Chen X., Optimization of Enzymolysis Clearance Strategy To Enhance Renal Clearance of Radioligands, Bioconjug Chem. 2021 Sep 15;32(9):2108-2116. doi: 10.1021/acs.bioconjchem.1c00392. Epub 2021 Sep 6.
Domenici G, Eduardo R, Castillo-Ecija H, Orive G, Montero Carcaboso Á, Brito C., PDX-Derived Ewing's Sarcoma Cells Retain High Viability and Disease Phenotype in Alginate Encapsulated Spheroid Cultures, Cancers (Basel). 2021 Feb 19;13(4):879. doi: 10.3390/cancers13040879.
Chen, Z., Dean-Ben, X. L., Gottschalk, S., & Razansky, D. (2018), Performance of optoacoustic and fluorescence imaging in detecting deep-seated fluorescent agents, Biomedical Optics Express, 9(5), 2229-2239. doi:10.1364/BOE.9.002229 [doi]
Khadria A, Paavola CD, Maslov K, Brown-Augsburger PL, Grealish PF, Lozano E, Blankenship RL, Cao R, Shi J, Beals JM, Oladipupo SS, Wang LV., Photoacoustic imaging of the dynamics of a dye-labeled IgG4 monoclonal antibody in subcutaneous tissue reveals a transient decrease in murine blood oxygenation under anesthesia., J Biomed Opt. 2023 Nov;28(11):116002. doi: 10.1117/1.JBO.28.11.116002. Epub 2023 Nov 30.
Lenz SM, Collins JH, Ray NA, Hagge DA, Lahiri R, Adams LB., Post-exposure prophylaxis (PEP) efficacy of rifampin, rifapentine, moxifloxacin, minocycline, and clarithromycin in a susceptible-subclinical model of leprosy, PLoS Negl Trop Dis. 2020 Sep 16;14(9):e0008583. doi: 10.1371/journal.pntd.0008583. eCollection 2020 Sep.
Bernardelli C, Chiaramonte E, Ancona S, Sirchia SM, Cerri A, Lesma E., Primary TSC2(-/meth) Cells Induce Follicular Neogenesis in an Innovative TSC Mouse Model, Int J Mol Sci. 2022 Aug 26;23(17):9713. doi: 10.3390/ijms23179713.
Houweling M, Abdul UK, Brahm C, Lagerweij T, Heukelom S, Koken PW, Honeywell R, Wedekind LE, Peters GJ, Verheul H, Sminia P, Noske D, Wurdinger T, Westerman BA., Radio-sensitizing effect of MEK inhibition in glioblastoma in vitro and in vivo, J Cancer Res Clin Oncol. 2022 Dec 1. doi: 10.1007/s00432-022-04483-3. Online ahead of print.
Basu, Sankha S; Regan, Michael S; Randall, Elizabeth C; Abdelmoula, Walid M; Clark, Amanda R; Gimenez-Cassina Lopez, BegoĂąa; Cornett, Dale S; Haase, Andreas; Santagata, Sandro; Agar, Nathalie Y R;, Rapid MALDI mass spectrometry imaging for surgical pathology., NPJ precision oncology Vol.3, 2019
LoCoco PM, Boyd JT, Espitia Olaya CM, Furr AR, Garcia DK, Weldon KS, Zou Y, Locke E, Tobon A, Lai Z, Ruparel SB, Ruparel NB, Hargreaves KM., Reliable approaches to extract high-integrity RNA from skin and other pertinent tissues used in pain research, Pain Rep. 2020 Mar 27;5(2):e818. doi: 10.1097/PR9.0000000000000818. eCollection 2020 Mar-Apr.
Peterson NC, Berlin AA., Risk Assessment for Use of a Porcine Circovirus-Contaminated Reagent in a Barrier Maintained Rodent Colony, J Am Assoc Lab Anim Sci. 2020 Sep 1;59(5):575-579. doi: 10.30802/AALAS-JAALAS-20-000012. Epub 2020 Jun 30.
Zhang Y, Hu P, Li L, Cao R, Khadria A, Maslov K, Tong X, Zeng Y, Jiang L, Zhou Q, Wang LV., Single-shot 3D photoacoustic tomography using a single-element detector for ultrafast imaging of hemodynamics., bioRxiv. 2023 Mar 15. pii: 2023.03.14.532661. doi: 10.1101/2023.03.14.532661. Update in: Nat Biomed Eng. 2023 Nov 30;:.
Maloney R, Buuh ZY, Zhao Y, Wang RE., Site-specific antibody fragment conjugates for targeted imaging, Methods Enzymol. 2020;638:295-320. doi: 10.1016/bs.mie.2020.02.023. Epub 2020 Mar 31.
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Immunology

Sanz-Ortega, Laura; Rojas, José M; Marcos, Ana; Portilla, Yadileiny; Stein, Jens V; Barber, Domingo F;, T cells loaded with magnetic nanoparticles are retained in peripheral lymph nodes by the application of a magnetic field., Journal of nanobiotechnology Vol.17, 2019
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Rios-Doria, J., Harper, J., Rothstein, R., Wetzel, L., Chesebrough, J., Marrero, A., . . . Hollingsworth, R. (2017)., Antibody-drug conjugates bearing pyrrolobenzodiazepine or tubulysin payloads are immunomodulatory and synergize with multiple immunotherapies., Cancer Research, 77(10), 2686-2698. doi:10.1158/0008-5472.CAN-16-2854 [doi]
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Rogovskyy, A. S., & Bankhead, T. (2014)., Bacterial heterogeneity is a requirement for host superinfection by the lyme disease spirochete., Infection and Immunity, 82(11), 4542-4552. doi:10.1128/IAI.01817-14 [doi]
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Puigdelloses M, Garcia-Moure M, Labiano S, Laspidea V, Gonzalez-Huarriz M, Zalacain M, Marrodan L, Martinez-Velez N, De la Nava D, Ausejo I, Hervás-Stubbs S, Herrador G, Chen Z, Hambardzumyan D, Patino Garcia A, Jiang H, Gomez-Manzano C, Fueyo J, Gállego Pérez-Larraya J, Alonso M., CD137 and PD-L1 targeting with immunovirotherapy induces a potent and durable antitumor immune response in glioblastoma models, J Immunother Cancer. 2021 Jul;9(7):e002644. doi: 10.1136/jitc-2021-002644.
Wedekind MF, Miller KE, Chen CY, Wang PY, Hutzen BJ, Currier MA, Nartker B, Roberts RD, Boon L, Conner J, LaHaye S, Kelly BJ, Gordon D, White P, Mardis ER, Cripe TP., Endogenous retrovirus envelope as a tumor-associated immunotherapeutic target in murine osteosarcoma, iScience. 2021 Jun 19;24(7):102759. doi: 10.1016/j.isci.2021.102759. eCollection 2021 Jul 23.
Alvero AB, Fox A, Madina BR, Krady MM, Gogoi R, Chehade H, Nakaar V, Almassian B, Yarovinsky TO, Rutherford T, Mor G., Immune modulation of innate and adaptive responses restores immune surveillance and establishes anti-tumor immunological memory., Cancer Immunol Res. 2023 Dec 11. doi: 10.1158/2326-6066.CIR-23-0127. [Epub ahead of print]
Ahmed MSU, Lord BD, Adu Addai B, Singhal SK, Gardner K, Salam AB, Ghebremedhin A, White J, Mahmud I, Martini R, Bedi D, Lin H, Jones JD, Karanam B, Dean-Colomb W, Grizzle W, Wang H, Davis M, Yates CC., Immune Profile of Exosomes in African American Breast Cancer Patients Is Mediated by Kaiso/THBS1/CD47 Signaling., Cancers (Basel). 2023 Apr 13;15(8). pii: 2282. doi: 10.3390/cancers15082282.
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Oncology

Siddique AB, Kilgore PCSR, Tajmim A, Singh SS, Meyer SA, Jois SD, Cvek U, Trutschl M, Sayed KAE., (-)-Oleocanthal as a Dual c-MET-COX2 Inhibitor for the Control of Lung Cancer, Nutrients. 2020 Jun 11;12(6):1749. doi: 10.3390/nu12061749.
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Marayati R, Bownes LV, Stafman LL, Williams AP, Quinn CH, Atigadda V, Aye JM, Stewart JE, Yoon KJ, Beierle EA., 9-cis-UAB30, a novel rexinoid agonist, decreases tumorigenicity and cancer cell stemness of human neuroblastoma patient-derived xenografts, Transl Oncol. 2021 Jan;14(1):100893. doi: 10.1016/j.tranon.2020.100893. Epub 2020 Sep 30.
Marayati R, Bownes LV, Stafman LL, Williams AP, Quinn CH, Atigadda V, Aye JM, Stewart JE, Yoon KJ, Beierle EA., 9-cis-UAB30, a novel rexinoid agonist, decreases tumorigenicity and cancer cell stemness of human neuroblastoma patient-derived xenografts, Transl Oncol. 2021 Jan;14(1):100893. doi: 10.1016/j.tranon.2020.100893. Epub 2020 Sep 30.
Deng, Y., Wang, Z., Zhang, F., Qiao, M., Yan, Z., Wei, Q., . . . Zhang, J. (2016), A blockade of IGF signaling sensitizes human ovarian cancer cells to the anthelmintic niclosamide-induced anti-proliferative and anticancer activities, Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 39(3), 871-888. doi:10.1159/000447797 [doi]
Kuznik NC, Solozobova V, Lee II, Jung N, Yang L, Nienhaus K, Ntim EA, Rottenberg JT, Muhle-Goll C, Kumar AR, Peravali R, Gräßle S, Gourain V, Deville C, Cato L, Neeb A, Dilger M, Cramer von Clausbruch CA, Weiss C, Kieffer B, Nienhaus GU, Brown M, Bräse S, Cato ACB., A chemical probe for BAG1 targets androgen receptor-positive prostate cancer through oxidative stress signaling pathway, iScience. 2022 Mar 31;25(5):104175. doi: 10.1016/j.isci.2022.104175. eCollection 2022 May 20.
Zhao Y, Wang C, Goel A., A combined treatment with melatonin and andrographis promotes autophagy and anticancer activity in colorectal cancer, Carcinogenesis. 2022 Apr 25;43(3):217-230. doi: 10.1093/carcin/bgac008.
Luderer, M. J., Muz, B., de la Puente, P., Chavalmane, S., Kapoor, V., Marcelo, R., . . . Azab, A. K. (2016), A hypoxia-targeted boron neutron capture therapy agent for the treatment of glioma., Pharmaceutical Research, 33(10), 2530-2539. doi:10.1007/s11095-016-1977-2 [doi]
Tian Q, Zhang P, Wang Y, Si Y, Yin D, Weber CR, Fishel ML, Pollok KE, Qiu B, Xiao F, Chong AS., A novel triptolide analog downregulates NF-kB and induces mitochondrial apoptosis pathways in human pancreatic cancer., Elife. 2023 Oct 25;12. pii: e85862. doi: 10.7554/eLife.85862. [Epub ahead of print]
Shivange G, Mondal T, Lyerly E, Bhatnagar S, Landen CN, Reddy S, Kim J, Doan B, Riddle P, Tushir-Singh J., A patch of positively charged residues regulates the efficacy of clinical DR5 antibodies in solid tumors, Cell Rep. 2021 Nov 2;37(5):109953. doi: 10.1016/j.celrep.2021.109953.
Hight, M. R., Cheung, Y. Y., Nickels, M. L., Dawson, E. S., Zhao, P., Saleh, S., . . . Manning, H. C. (2014)., A peptide-based positron emission tomography probe for in vivo detection of caspase activity in apoptotic cells., Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 20(8), 2126-2135. doi:10.1158/1078-0432.CCR-13-2444 [doi]
Dey, J., Kerwin, W. S., Grenley, M. O., Casalini, J. R., Tretyak, I., Ditzler, S. H., . . . Klinghoffer, R. A. (2016), A platform for rapid, quantitative assessment of multiple drug combinations simultaneously in solid tumors in vivo., PloS One, 11(6), e0158617. doi:10.1371/journal.pone.0158617 [doi]
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Yang, Lu; Li, Yun; Bhattacharya, Arup; Zhang, Yuesheng;, A recombinant human protein targeting HER2 overcomes drug resistance in HER2-positive breast cancer., Science translational medicine Vol.11, 2019
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Santich BH, Cheal SM, Ahmed M, McDevitt MR, Ouerfelli O, Yang G, Veach DR, Fung EK, Patel M, Burnes Vargas D, Malik AA, Guo HF, Zanzonico PB, Monette S, Michel AO, Rudin CM, Larson SM, Cheung NK., A Self-Assembling and Disassembling (SADA) Bispecific Antibody (BsAb) Platform for Curative Two-step Pretargeted Radioimmunotherapy, Clin Cancer Res. 2020 Sep 21. doi: 10.1158/1078-0432.CCR-20-2150. Online ahead of print.
Santich BH, Cheal SM, Ahmed M, McDevitt MR, Ouerfelli O, Yang G, Veach DR, Fung EK, Patel M, Burnes Vargas D, Malik AA, Guo HF, Zanzonico PB, Monette S, Michel AO, Rudin CM, Larson SM, Cheung NK., A Self-Assembling and Disassembling (SADA) Bispecific Antibody (BsAb) Platform for Curative Two-step Pretargeted Radioimmunotherapy, Clin Cancer Res. 2021 Jan 15;27(2):532-541. doi: 10.1158/1078-0432.CCR-20-2150. Epub 2020 Sep 21.
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Li M, Li J, Guo X, Pan H, Zhou Q., Absence of HTATIP2 Expression in A549 Lung Adenocarcinoma Cells Promotes Tumor Plasticity in Response to Hypoxic Stress, Cancers (Basel). 2020 Jun 11;12(6):1538. doi: 10.3390/cancers12061538.
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Young, N. R., Soneru, C., Liu, J., Grushko, T. A., Hardeman, A., Olopade, O. I., . . . Cohen, E. E. (2015)., Afatinib efficacy against squamous cell carcinoma of the head and neck cell lines in vitro and in vivo., Targeted Oncology, 10(4), 501-508. doi:10.1007/s11523-014-0353-6 [doi]
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Dunn S, Eberlein C, Yu J, Gris-Oliver A, Ong SH, Yelland U, Cureton N, Staniszewska A, McEwen R, Fox M, Pilling J, Hopcroft P, Coker EA, Jaaks P, Garnett MJ, Isherwood B, Serra V, Davies BR, Barry ST, Lynch JT, Yusa K., AKT-mTORC1 reactivation is the dominant resistance driver for PI3Kβ/AKT inhibitors in PTEN-null breast cancer and can be overcome by combining with Mcl-1 inhibitors, Oncogene. 2022 Nov;41(46):5046-5060. doi: 10.1038/s41388-022-02482-9. Epub 2022 Oct 14.
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Zhang, R., Pan, D., Cai, X., Yang, X., Senpan, A., Allen, J. S., . . . Wang, L. V. (2015), alphaVbeta3-targeted copper nanoparticles incorporating an sn 2 lipase-labile fumagillin prodrug for photoacoustic neovascular imaging and treatment., Theranostics, 5(2), 124-133. doi:10.7150/thno.10014 [doi]
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O'Steen, S., Green, D. J., Gopal, A. K., Orozco, J. J., Kenoyer, A. L., Lin, Y., . . . Press, O. W. (2017)., Venetoclax synergizes with radiotherapy for treatment of B-cell lymphomas., Cancer Research, 77(14), 3885-3893. doi:10.1158/0008-5472.CAN-17-0082 [doi]
Smith BD, Kaufman MD, Wise SC, Ahn YM, Caldwell TM, Leary CB, Lu WP, Tan G, Vogeti L, Vogeti S, Wilky BA, Davis LE, Sharma M, Ruiz-Soto R, Flynn DL., Vimseltinib: A Precision CSF1R Therapy for Tenosynovial Giant Cell Tumors and Diseases Promoted by Macrophages, Mol Cancer Ther. 2021 Nov;20(11):2098-2109. doi: 10.1158/1535-7163.MCT-21-0361. Epub 2021 Aug 25.
Patil, S. S., Gentschev, I., Adelfinger, M., Donat, U., Hess, M., Weibel, S., . . . Szalay, A. A. (2012)., Virotherapy of canine tumors with oncolytic vaccinia virus GLV-1h109 expressing an anti-VEGF single-chain antibody, PloS One, 7(10), e47472. doi:10.1371/journal.pone.0047472 [doi]
Kim SI, Chaurasiya S, Park AK, Kang S, Lu J, Woo Y, Yin HH, Yin Z, Fong Y, Warner SG., Vitamin D as a Primer for Oncolytic Viral Therapy in Colon Cancer Models, Int J Mol Sci. 2020 Oct 3;21(19):7326. doi: 10.3390/ijms21197326.
Thomson CS, Pundavela J, Perrino MR, Coover RA, Choi K, Chaney KE, Rizvi TA, Largaespada DA, Ratner N., WNT5A inhibition alters the malignant peripheral nerve sheath tumor microenvironment and enhances tumor growth, Oncogene. 2021 Jun;40(24):4229-4241. doi: 10.1038/s41388-021-01773-x. Epub 2021 Jun 2.
Stein, A. P., Swick, A. D., Smith, M. A., Blitzer, G. C., Yang, R. Z., Saha, S., . . . Kimple, R. J. (2015)., Xenograft assessment of predictive biomarkers for standard head and neck cancer therapies, Cancer Medicine, 4(5), 699-712. doi:10.1002/cam4.387 [doi]
Zhang, Q., Sun, X., Yang, J., Ding, H., LeBrun, D., Ding, K., . . . Li, M. (2015)., ZIP4 silencing improves bone loss in pancreatic cancer., Oncotarget, 6(28), 26041-26051. doi:10.18632/oncotarget.4667 [doi]
Del Vecchio V, Mele L, Panda SK, Sanchez-Pajares IR, Mosca L, Tirino V, Barbieri M, Bruzzese F, Luciano A, Marino FZ, Accardo M, Nicoletti GF, Papaccio G, Barbieri A, Desiderio V., β2-AR inhibition enhances EGFR antibody efficacy hampering the oxidative stress response machinery, Cell Death Dis. 2023 Sep 19;14(9):613. doi: 10.1038/s41419-023-06129-9.
Cam M, Charan M, Welker AM, Dravid P, Studebaker AW, Leonard JR, Pierson CR, Nakano I, Beattie CE, Hwang EI, Kambhampati M, Nazarian J, Finlay JL, Cam H., ΔNp73/ETS2 complex drives glioblastoma pathogenesis- targeting downstream mediators by rebastinib prolongs survival in preclinical models of glioblastoma, Neuro Oncol. 2020 Mar 5;22(3):345-356. doi: 10.1093/neuonc/noz190.

Surgical

Servetto A, Kollipara R, Formisano L, Lin CC, Lee KM, Sudhan DR, Gonzalez-Ericsson PI, Chatterjee S, Guerrero-Zotano A, Mendiratta S, Akamatsu H, James N, Bianco R, Hanker AB, Kittler R, Arteaga CL., Nuclear FGFR1 Regulates Gene Transcription and Promotes Antiestrogen Resistance in ER(+) Breast Cancer., Clin Cancer Res. 2021 Aug 1;27(15):4379-4396. doi: 10.1158/1078-0432.CCR-20-3905. Epub 2021 May 19.

Transplantation

Bansal A, Pandey MK, Yamada S, Goyal R, Schmit NR, Jeon R, Nesbitt JJ, Witt TA, Singh RD, Gunderson TM, Boroumand S, Li M, Crespo-Diaz RJ, Hillestad ML, Terzic A, Behfar A, DeGrado TR., [(89)Zr]Zr-DBN labeled cardiopoietic stem cells proficient for heart failure, Nucl Med Biol. 2020 Nov-Dec;90-91:23-30. doi: 10.1016/j.nucmedbio.2020.09.001. Epub 2020 Sep 9.
Xu, J., Li, K., Smith, R. A., Waterton, J. C., Zhao, P., Ding, Z., . . . Gore, J. C. (2017)., A comparative assessment of preclinical chemotherapeutic response of tumors using quantitative non-gaussian diffusion MRI, Magnetic Resonance Imaging, 37, 195-202. doi:S0730-725X(16)30239-9 [pii]
Caffrey, P. B., Frenkel, G. D., McAndrew, K. L., & Marks, K. (2016)., A model of the development of cisplatin resistance in human small cell lung cancer xenografts, In Vivo (Athens, Greece), 30(6), 745-749. doi:30/6/745 [pii]
Shimoda, M., Chen, S., Noguchi, H., Takita, M., Sugimoto, K., Itoh, T., . . . Grayburn, P. A. (2014)., A new method for generating insulin-secreting cells from human pancreatic epithelial cells after islet isolation transformed by NeuroD1., Human Gene Therapy Methods, 25(3), 206-219. doi:10.1089/hgtb.2013.122 [doi]
Curtin, C., Nolan, J. C., Conlon, R., Deneweth, L., Gallagher, C., Tan, Y. J., . . . Piskareva, O. (2018)., A physiologically relevant 3D collagen-based scaffold-neuroblastoma cell system exhibits chemosensitivity similar to orthotopic xenograft models. Acta, Acta Biomaterialia, 70, 84-97. doi:S1742-7061(18)30074-6 [pii]
Hou, F., Dai, Y., Suen, J. Y., Fan, C., Saad, A. G., & Richter, G. T. (2013)., A xenograft animal model of human arteriovenous malformations, Orphanet Journal of Rare Diseases, 8, 199-1172-8-199. doi:10.1186/1750-1172-8-199 [doi]
Borgogna, C., Olivero, C., Lanfredini, S., Calati, F., De Andrea, M., Zavattaro, E., . . . Gariglio, M. (2018)., Beta-HPV infection correlates with early stages of carcinogenesis in skin tumors and patient-derived xenografts from a kidney transplant recipient cohort., Frontiers in Microbiology, 9, 117. doi:10.3389/fmicb.2018.00117 [doi]
Yan, S., Zhang, R., Wu, K., Cui, J., Huang, S., Ji, X., . . . Weng, Y. (2018)., Characterization of the essential role of bone morphogenetic protein 9 (BMP9) in osteogenic differentiation of mesenchymal stem cells (MSCs) through RNA interference., Genes & Diseases, 5(2), 172-184. doi:10.1016/j.gendis.2018.04.006 [doi]
Yu Q, DiFeo Jacquet R, Landis WJ., Characterization of Tissue-Engineered Human Periosteum and Allograft Bone Constructs: The Potential of Periosteum in Bone Regenerative Medicine, Cells Tissues Organs. 2020;209(2-3):128-143. doi: 10.1159/000509036. Epub 2020 Sep 16.
Howard, C. B., McDowell, R., Feleke, K., Deer, E., Stamps, S., Thames, E., . . . Pervin, S. (2016)., Chemotherapeutic vulnerability of triple-negative breast cancer cell-derived tumors to pretreatment with vernonia amygdalina aqueous extracts., Anticancer Research, 36(8), 3933-3943. doi:36/8/3933 [pii]
Kilinc, M. O., Ehrig, K., Pessian, M., Minev, B. R., & Szalay, A. A. (2016)., Colonization of xenograft tumors by oncolytic vaccinia virus (VACV) results in enhanced tumor killing due to the involvement of myeloid cells., Journal of Translational Medicine, 14(1), 340-016-1096-1. doi:10.1186/s12967-016-1096-1 [doi]
Pastor, D., Viso-Leon, M. C., Jones, J., Jaramillo-Merchan, J., Toledo-Aral, J. J., Moraleda, J. M., & Martinez, S. (2012)., Comparative effects between bone marrow and mesenchymal stem cell transplantation in GDNF expression and motor function recovery in a motorneuron degenerative mouse model., Stem Cell Reviews, 8(2), 445-458. doi:10.1007/s12015-011-9295-x [doi]
Citro, L., Naidu, S., Hassan, F., Kuppusamy, M. L., Kuppusamy, P., Angelos, M. G., & Khan, M. (2014)., Comparison of human induced pluripotent stem-cell derived cardiomyocytes with human mesenchymal stem cells following acute myocardial infarction, PloS One, 9(12), e116281. doi:10.1371/journal.pone.0116281 [doi]
Corona, B. T., Henderson, B. E., Ward, C. L., & Greising, S. M. (2017)., Contribution of minced muscle graft progenitor cells to muscle fiber formation after volumetric muscle loss injury in wild-type and immune deficient mice., Physiological Reports, 5(7), 10.14814/phy2.13249. doi:e13249 [pii]
Rodriguez Calleja, L., Jacques, C., Lamoureux, F., Baud'huin, M., Tellez Gabriel, M., Quillard, T., . . . Ory, B. (2016)., DeltaNp63alpha silences a miRNA program to aberrantly initiate a wound-healing program that promotes TGFbeta-induced metastasis, Cancer Research, 76(11), 3236-3251. doi:10.1158/0008-5472.CAN-15-2317 [doi]
Lee, C. W., Guo, L., Matei, D., & Stantz, K. (2015)., Development of follicle-stimulating hormone receptor binding probes to image ovarian xenografts, Journal of Biotechnology & Biomaterials, 5(3), 10.4172/2155-952X.1000198. Epub 2015 Sep 10. doi:198 [pii]
Kiseljak-Vassiliades, K., Zhang, Y., Bagby, S. M., Kar, A., Pozdeyev, N., Xu, M., . . . Wierman, M. E. (2018)., Development of new preclinical models to advance adrenocortical carcinoma research., Endocrine-Related Cancer, 25(4), 437-451. doi:10.1530/ERC-17-0447 [doi]
Song D, Huang S, Zhang L, Liu W, Huang B, Feng Y, Liu B, He TC, Huang D, Reid RR., Differential Responsiveness to BMP9 between Patent and Fused Suture Progenitor Cells from Craniosynostosis Patients, Plast Reconstr Surg. 2020 Mar;145(3):552e-562e. doi: 10.1097/PRS.0000000000006597.
Yang, Y. C., Liem, A., Lambert, P. F., & Sugden, B. (2017)., Dissecting the regulation of EBV's BART miRNAs in carcinomas, Virology, 505, 148-154. doi:S0042-6822(17)30054-5 [pii]
Novella-Maestre, E., Herraiz, S., Vila-Vives, J. M., Carda, C., Ruiz-Sauri, A., & Pellicer, A. (2012)., Effect of antiangiogenic treatment on peritoneal endometriosis-associated nerve fibers., Fertility and Sterility, 98(5), 1209-1217. doi:10.1016/j.fertnstert.2012.07.1103 [doi]
Yu, X., Chen, L., Wu, K., Yan, S., Zhang, R., Zhao, C., . . . Gan, H. (2018)., Establishment and functional characterization of the reversibly immortalized mouse glomerular podocytes (imPODs)., Genes & Diseases, 5(2), 137-149. doi:10.1016/j.gendis.2018.04.003 [doi]
Rodriguez, M., Silva, J., Herrera, A., Herrera, M., Pena, C., Martin, P., . . . Garcia-Barberan, V. (2015)., Exosomes enriched in stemness/metastatic-related mRNAS promote oncogenic potential in breast cancer., Oncotarget, 6(38), 40575-40587. doi:10.18632/oncotarget.5818 [doi]
Hoppela, E., Gronroos, T. J., Saarikko, A. M., Tervala, T. V., Kauhanen, S., Nuutila, P., . . . Hartiala, P. (2018)., Fat grafting can induce browning of white adipose tissue., Plastic and Reconstructive Surgery.Global Open, 6(6), e1804. doi:10.1097/GOX.0000000000001804 [doi]
Hubmann, R., Sieghart, W., Schnabl, S., Araghi, M., Hilgarth, M., Reiter, M., . . . Shehata, M. (2017)., Gliotoxin targets nuclear NOTCH2 in human solid tumor derived cell lines in vitro and inhibits melanoma growth in xenograft mouse model., Frontiers in Pharmacology, 8, 319. doi:10.3389/fphar.2017.00319 [doi]
Bueno, C., Ramirez, C., Rodriguez-Lozano, F. J., Tabares-Seisdedos, R., Rodenas, M., Moraleda, J. M., . . . Martinez, S. (2013)., Human adult periodontal ligament-derived cells integrate and differentiate after implantation into the adult mammalian brain, Cell Transplantation, 22(11), 2017-2028. doi:10.3727/096368912X657305 [doi]
Sareen, D., Gowing, G., Sahabian, A., Staggenborg, K., Paradis, R., Avalos, P., . . . Svendsen, C. N. (2014)., Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord., The Journal of Comparative Neurology, 522(12), 2707-2728. doi:10.1002/cne.23578 [doi]
Hernandez-Gonzalez F, Prats N, Ramponi V, López-Domínguez JA, Meyer K, Aguilera M, Muñoz Martín MI, Martínez D, Agusti A, Faner R, Sellarés J, Pietrocola F, Serrano M., Human senescent fibroblasts trigger progressive lung fibrosis in mice., Aging (Albany NY). 2023 Jul 1;15(14):6641-6657. doi: 10.18632/aging.204825. Epub 2023 Jul 1.
Melsens, E., De Vlieghere, E., Descamps, B., Vanhove, C., Kersemans, K., De Vos, F., . . . Pattyn, P. (2018)., Hypoxia imaging with (18)F-FAZA PET/CT predicts radiotherapy response in esophageal adenocarcinoma xenografts., Radiation Oncology (London, England), 13(1), 39-018-0984-3. doi:10.1186/s13014-018-0984-3 [doi]
Benavides, O. M., Brooks, A. R., Cho, S. K., Petsche Connell, J., Ruano, R., & Jacot, J. G. (2015)., In situ vascularization of injectable fibrin/poly(ethylene glycol) hydrogels by human amniotic fluid-derived stem cells., Journal of Biomedical Materials Research.Part A, 103(8), 2645-2653. doi:10.1002/jbm.a.35402 [doi]
Smink AM, Skrzypek K, Liefers-Visser JAL, Kuwabara R, de Haan BJ, de Vos P, Stamatialis D., In vivovascularization and islet function in a microwell device for pancreatic islet transplantation, Biomed Mater. 2021 Apr 21;16(3). doi: 10.1088/1748-605X/abf5ec.
Zhang B, Yang L, Zeng Z, Feng Y, Wang X, Wu X, Luo H, Zhang J, Zhang M, Pakvasa M, Wagstaff W, He F, Mao Y, Qin K, Ding H, Zhang Y, Niu C, Wu M, Zhao X, Wang H, Huang L, Shi D, Liu Q, Ni N, Fu K, Athiviraham A, Moriatis Wolf J, Lee MJ, Hynes K, Strelzow J, El Dafrawy M, Xia Y, He TC., Leptin Potentiates BMP9-Induced Osteogenic Differentiation of Mesenchymal Stem Cells Through the Activation of JAK/STAT Signaling, Stem Cells Dev. 2020 Apr 15;29(8):498-510. doi: 10.1089/scd.2019.0292. Epub 2020 Mar 9.
Brand, C., Sadique, A., Houghton, J. L., Gangangari, K., Ponte, J. F., Lewis, J. S., . . . Reiner, T. (2018), Leveraging PET to image folate receptor alpha therapy of an antibody-drug conjugate., EJNMMI Research, 8(1), 87-018-0437-x. doi:10.1186/s13550-018-0437-x [doi]
Page, J. M., Merkel, A. R., Ruppender, N. S., Guo, R., Dadwal, U. C., Cannonier, S., . . . Sterling, J. A. (2015)., Matrix rigidity regulates the transition of tumor cells to a bone-destructive phenotype through integrin beta3 and TGF-beta receptor type II., Biomaterials, 64, 33-44. doi:10.1016/j.biomaterials.2015.06.026 [doi]
Walker MM, Baumann ME, Alexander JH, Blackstone BN, Morgan CB, Scharschmidt TJ, Powell HM., Mechanical strain induces ex vivo expansion of periosteum, PLoS One. 2022 Dec 30;17(12):e0279519. doi: 10.1371/journal.pone.0279519. eCollection 2022.
Rooj, A. K., Ricklefs, F., Mineo, M., Nakano, I., Chiocca, E. A., Bronisz, A., & Godlewski, J. (2017)., MicroRNA-mediated dynamic bidirectional shift between the subclasses of glioblastoma stem-like cells., Cell Reports, 19(10), 2026-2032. doi:S2211-1247(17)30682-4 [pii]
Biyashev, D., Veliceasa, D., Topczewski, J., Topczewska, J. M., Mizgirev, I., Vinokour, E., . . . Volpert, O. V. (2012), miR-27b controls venous specification and tip cell fate, Blood, 119(11), 2679-2687. doi:10.1182/blood-2011-07-370635 [doi]
Tjalma, J. J., Garcia-Allende, P. B., Hartmans, E., Terwisscha van Scheltinga, A. G., Boersma-van Ek, W., Glatz, J., . . . Nagengast, W. B. (2016)., Molecular fluorescence endoscopy targeting vascular endothelial growth factor A for improved colorectal polyp detection., Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine, 57(3), 480-485. doi:10.2967/jnumed.115.166975 [doi]
Vaes B, Van Houtven E, Caluwé E, Luttun A., Multipotent adult progenitor cells grown under xenobiotic-free conditions support vascularization during wound healing, Stem Cell Res Ther. 2020 Sep 7;11(1):389. doi: 10.1186/s13287-020-01912-3.
Cidonio G, Glinka M, Kim YH, Kanczler JM, Lanham SA, Ahlfeld T, Lode A, Dawson JI, Gelinsky M, Oreffo ROC., Nanoclay-based 3D printed scaffolds promote vascular ingrowth ex vivo and generate bone mineral tissue in vitro and in vivo, Biofabrication. 2020 May 12;12(3):035010. doi: 10.1088/1758-5090/ab8753.
Liao, J., Wei, Q., Zou, Y., Fan, J., Song, D., Cui, J., . . . Huang, W. (2017)., Notch signaling augments BMP9-induced bone formation by promoting the osteogenesis-angiogenesis coupling process in mesenchymal stem cells (MSCs)., Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 41(5), 1905-1923. doi:10.1159/000471945 [doi]
O'Leary, M. P., Choi, A. H., Kim, S. I., Chaurasiya, S., Lu, J., Park, A. K., . . . Chen, N. G. (2018)., Novel oncolytic chimeric orthopoxvirus causes regression of pancreatic cancer xenografts and exhibits abscopal effect at a single low dose, Journal of Translational Medicine, 16(1), 110-018-1483-x. doi:10.1186/s12967-018-1483-x [doi]
Studebaker, A. W., Hutzen, B. J., Pierson, C. R., Haworth, K. B., Cripe, T. P., Jackson, E. M., & Leonard, J. R. (2017), Oncolytic herpes virus rRp450 shows efficacy in orthotopic xenograft group 3/4 medulloblastomas and atypical Teratoid/Rhabdoid tumors., Molecular Therapy Oncolytics, 6, 22-30. doi:10.1016/j.omto.2017.05.005 [doi]
Dost AFM, Moye AL, Vedaie M, Tran LM, Fung E, Heinze D, Villacorta-Martin C, Huang J, Hekman R, Kwan JH, Blum BC, Louie SM, Rowbotham SP, Sainz de Aja J, Piper ME, Bhetariya PJ, Bronson RT, Emili A, Mostoslavsky G, Fishbein GA, Wallace WD, Krysan K, Dubinett SM, Yanagawa J, Kotton DN, Kim CF., Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells, Cell Stem Cell. 2020 Oct 1;27(4):663-678.e8. doi: 10.1016/j.stem.2020.07.022. Epub 2020 Sep 4.
Golan, T., Stossel, C., Schvimer, M., Atias, D., Halperin, S., Buzhor, E., . . . Berger, R. (2017)., Pancreatic cancer ascites xenograft-an expeditious model mirroring advanced therapeutic resistant disease, Oncotarget, 8(25), 40778-40790. doi:10.18632/oncotarget.17253 [doi]
Gong, H., An, S., Sassmann, A., Liu, M., Mastej, V., Mittal, M., . . . Malik, A. B. (2016)., PAR1 scaffolds TGFbetaRII to downregulate TGF-beta signaling and activate ESC differentiation to endothelial cells, Stem Cell Reports, 7(6), 1050-1058. doi:S2213-6711(16)30244-2 [pii]
Chao, C., Widen, S. G., Wood, T. G., Zatarain, J. R., Johnson, P., Gajjar, A., . . . Hellmich, M. R. (2017)., Patient-derived xenografts from colorectal carcinoma: A temporal and hierarchical study of murine stromal cell replacement., Anticancer Research, 37(7), 3405-3412. doi:37/7/3405 [pii]
Tamayo A, Gonçalves LM, Rodriguez-Diaz R, Pereira E, Canales M, Caicedo A, Almaça J., Pericyte Control of Blood Flow in Intraocular Islet Grafts Impacts Glucose Homeostasis in Mice, Diabetes. 2022 Aug 1;71(8):1679-1693. doi: 10.2337/db21-1104.
Leone MA, Gelati M, Profico DC, Gobbi C, Pravatà E, Copetti M, Conti C, Abate L, Amoruso L, Apollo F, Balzano RF, Bicchi I, Carella M, Ciampini A, Colosimo C, Crociani P, D'Aloisio G, Di Viesti P, Ferrari D, Fogli D, Fontana A, Frondizi D, et al., Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis., Cell Stem Cell. 2023 Dec 7;30(12):1597-1609.e8. doi: 10.1016/j.stem.2023.11.001. Epub 2023 Nov 27.
Bashyal N, Kim MG, Jung JH, Acharya R, Lee YJ, Hwang WS, Choi JM, Chang DY, Kim SS, Suh-Kim H., Preclinical Study on Biodistribution of Mesenchymal Stem Cells after Local Transplantation into the Brain., Int J Stem Cells. 2023 Nov 30;16(4):415-424. doi: 10.15283/ijsc23062. Epub 2023 Aug 30.
Nichols-Burns, S. M., Lotz, L., Schneider, H., Adamek, E., Daniel, C., Stief, A., . . . Dittrich, R. (2014)., Preliminary observations on whole-ovary xenotransplantation as an experimental model for fertility preservation., Reproductive Biomedicine Online, 29(5), 621-626. doi:10.1016/j.rbmo.2014.07.017 [doi]
Philips, B. J., Grahovac, T. L., Valentin, J. E., Chung, C. W., Bliley, J. M., Pfeifer, M. E., . . . Rubin, J. P. (2013)., Prevalence of endogenous CD34+ adipose stem cells predicts human fat graft retention in a xenograft model., Plastic and Reconstructive Surgery, 132(4), 845-858. doi:10.1097/PRS.0b013e31829fe5b1 [doi]
Manuel, C. A., Bagby, S. M., Reisinger, J. A., Pugazhenthi, U., Pitts, T. M., Keysar, S. B., . . . Leszczynski, J. K. (2017)., Procedure for horizontal transfer of patient-derived xenograft tumors to eliminate corynebacterium bovis., Journal of the American Association for Laboratory Animal Science : JAALAS, 56(2), 166-172.
Louie SM, Moye AL, Wong IG, Lu E, Shehaj A, Garcia-de-Alba C, Ararat E, Raby BA, Lu B, Paschini M, Bronson RT, Kim CF., Progenitor potential of lung epithelial organoid cells in a transplantation model, Cell Rep. 2022 Apr 12;39(2):110662. doi: 10.1016/j.celrep.2022.110662.
Banerjee, J., Papu John, A. M., & Schuller, H. M. (2015)., Regulation of nonsmall-cell lung cancer stem cell like cells by neurotransmitters and opioid peptides., International Journal of Cancer, 137(12), 2815-2824. doi:10.1002/ijc.29646 [doi]
Jimenez-Valerio, G., Martinez-Lozano, M., Bassani, N., Vidal, A., Ochoa-de-Olza, M., Suarez, C., . . . Casanovas, O. (2016), Resistance to antiangiogenic therapies by metabolic symbiosis in renal cell carcinoma PDX models and patients, Cell Reports, 15(6), 1134-1143. doi:10.1016/j.celrep.2016.04.015 [doi]
De Cian MC, Gregoire EP, Le Rolle M, Lachambre S, Mondin M, Bell S, Guigon CJ, Chassot AA, Chaboissier MC., R-spondin2 signaling is required for oocyte-driven intercellular communication and follicular growth, Cell Death Differ. 2020 Oct;27(10):2856-2871. doi: 10.1038/s41418-020-0547-7. Epub 2020 Apr 27.
Collins KB, Kang H, Matsche J, Klomp JE, Rehman J, Malik AB, Karginov AV., Septin2 mediates podosome maturation and endothelial cell invasion associated with angiogenesis, J Cell Biol. 2020 Feb 3;219(2):e201903023. doi: 10.1083/jcb.201903023.
Rohira, A. D., Yan, F., Wang, L., Wang, J., Zhou, S., Lu, A., . . . O'Malley, B. W. (2017)., Targeting SRC coactivators blocks the tumor-initiating capacity of cancer stem-like cells, . Cancer Research, 77(16), 4293-4304. doi:10.1158/0008-5472.CAN-16-2982 [doi]
Naftali-Shani, N., Itzhaki-Alfia, A., Landa-Rouben, N., Kain, D., Holbova, R., Adutler-Lieber, S., . . . Leor, J. (2013)., The origin of human mesenchymal stromal cells dictates their reparative properties, Journal of the American Heart Association, 2(5), e000253. doi:10.1161/JAHA.113.000253 [doi]
Schultz, M. J., Holdbrooks, A. T., Chakraborty, A., Grizzle, W. E., Landen, C. N., Buchsbaum, D. J., . . . Bellis, S. L. (2016)., The tumor-associated glycosyltransferase ST6Gal-I regulates stem cell transcription factors and confers a cancer stem cell phenotype., Cancer Research, 76(13), 3978-3988. doi:10.1158/0008-5472.CAN-15-2834 [doi]
Thoma, D. S., Villar, C. C., Cochran, D. L., Hammerle, C. H., & Jung, R. E. (2012)., Tissue integration of collagen-based matrices: An experimental study in mice, Clinical Oral Implants Research, 23(12), 1333-1339. doi:10.1111/j.1600-0501.2011.02356.x [doi]

Tumor cell growth

Giesen D, Hooge MNL, Nijland M, Heyerdahl H, Dahle J, de Vries EGE, Pool M., (89)Zr-PET imaging to predict tumor uptake of (177)Lu-NNV003 anti-CD37 radioimmunotherapy in mouse models of B cell lymphoma, Sci Rep. 2022 Apr 15;12(1):6286. doi: 10.1038/s41598-022-10139-6.
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