Inotiv

ICR (CD-1®) outbred mice

Strains
Hsd:ICR (CD-1®)

ICR (CD-1®) Mice: The Versatile Workhorses of Biomedical Research

ICRICR (CD-1®) outbred mice, originally derived from Swiss albino mice, are widely used in biomedical research due to their high reproductive performance, rapid growth, and strong adaptability to environment. These mice serve as excellent models in a broad range of research fields, including aging, toxicology, pharmacology, oncology, immunology, and vaccine research. Their robust health and genetic variability closely mirror the genetic diversity found in human populations, making them highly valuable in the field of medical research.

For more ICR mouse information, technical data, and pricing, please visit our stock-specific resources page:

Applications of ICR Mice in Toxicology Research

In the sphere of toxicology research, ICR (CD-1®) outbred mice serve as a premier model due to their significant physiological resilience and genetic diversity. Their susceptibility to a wide variety of toxic agents offers researchers the opportunity to study not only the acute effects but also the chronic consequences of exposure to these substances. ICR mice are frequently employed in the testing of new drugs and chemicals to evaluate potential human health risks. Their robust health status equips them to withstand long-term studies, providing invaluable insights into the cumulative impacts of toxin exposure. Furthermore, the genetic variation within the ICR outbred population allows for the assessment of inter-individual differences in response to toxic agents, offering a closer approximation to human genetic diversity and response variability.

ICR mice have established themselves as a valuable model in the field of biomedical research due to several distinct features. Firstly, they exhibit a high reproduction rate with large litter sizes. Secondly, they have excellent immune responses, making them ideal for immunology related studies. Thirdly, ICR mice also showcase a robust health status and adaptability to a variety of environments. The genetic diversity of the ICR strain also provides a more realistic representation of the genetic diversity found in human populations. Lastly, they are a cost-effective choice, which is particularly important in large-scale, long-term studies.

ICR (CD-1®) Mice in Infectious Disease Research

In the realm of infectious disease research, ICR (CD-1®) mice are a versatile model due to their robust immune response and genetic diversity. They have been extensively utilized for studies related to a wide range of pathogens—from bacteria and viruses to parasites. These mice are particularly indispensable in research on infectious diseases that have a substantial genetic component to susceptibility. For instance, ICR mice have been used to explore host-pathogen interactions, disease progression, and potential vaccines and treatment options for conditions such as malaria, West Nile, Zika virus, and tuberculosis. The genetic diversity within the ICR population helps model the different responses to infections seen in human populations, contributing to the development of more effective and personalized treatment strategies. However, as with all models, researchers must consider the limitations and ensure their study design accounts for any potential confounding factors.

Genetic Characteristics of ICR Mice

ICR (CD-1®) outbred mice exhibit remarkable genetic diversity, a critical factor that elevates their utility in biomedical research. This genetic diversity mirrors the heterogeneity found in human populations, thereby rendering them suitable for studies aiming to understand the effects of genetic variances on disease susceptibility and drug responses. The ICR mice are an outbred stock, meaning they have more genetic variation as compared to inbred strains, much like humans in a population. Furthermore, the genetic variation in ICR mice also provides unique insights into the role of genetics in individual responses to toxic agents, new drugs, and the development of personalized medicines.

This mouse strain is known for its albino coat, which is characterized by a lack of pigmentation. Along with its striking appearance, these mice have a docile disposition, making them easy to handle and work with in research settings. Additionally, they exhibit excellent reproductive and maternal characteristics, making them ideal for breeding studies.

However, it's important to note that this mouse stock also has a high incidence of retinal degeneration caused by the Pde6brd1Pde6brd1 mutation. Researchers should consider this when designing experiments involving visual function. Despite this genetic predisposition, these mice have a relatively large litter average of 11.5, which contributes to their popularity as a widely-used outbred mouse strain in various research fields.

The Origin of ICR Mice

Hsd:ICR (CD-1®) mouse model originated in Switzerland and traces back to two male and seven female albino non-inbred mice that were imported from Lausanne in 1926 by the Rockefeller Institute. Descendants of these mice were distributed globally, and in 1948, the Ha/ICR strain was established at the Institute of Cancer Research (ICR). A portion of the Ha/ICR colony was later transferred to the Roswell Park Memorial Institute (RPMI). In 1959, Charles River Laboratories (CRL) obtained their breeding nucleus from RPMI and performed caesarean rederivation. Harlan acquired breeding stock from CRL in 1983. Harlan subsequently rebranded as Envigo in 2015, then Envigo was acquired by Inotiv in 2021.

Characteristics

  • Coat: Albino
  • Docile disposition
  • Excellent reproductive and maternal characteristics
  • High incidence of retinal degeneration (Pde6brd1)
  • Litter Average: 11.5
  • Most widely-used outbred mouse

ICR (CD-1®) outbred mice publications

Aging
COVID-19
General studies
Infectious disease
Oncology
Teratology
Toxicology
Vaccines

Aging

Infantino R, Boccella S, Scuteri D, Perrone M, Ricciardi F, Vitale RM, Bonsale R, Parente A, Allocca I, Virtuoso A, De Luca C, Belardo C, Amodeo P, Gentile V, Cirillo G, Bagetta G, Luongo L, Maione S, Guida F., 2-pentadecyl-2-oxazoline prevents cognitive and social behaviour impairments in the Amyloid β-induced Alzheimer-like mice model: Bring the α2 adrenergic receptor back into play, Biomed Pharmacother. 2022 Dec;156:113844. doi: 10.1016/j.biopha.2022.113844. Epub 2022 Oct 15.
Hood, W. R. (2012)., A test of bone mobilization relative to reproductive demand: Skeletal quality is improved in cannibalistic females with large litters., Physiological and Biochemical Zoology : PBZ, 85(4), 385-396. doi:10.1086/666057 [doi]
Impellizzeri D, D'Amico R, Fusco R, Genovese T, Peritore AF, Gugliandolo E, Crupi R, Interdonato L, Di Paola D, Di Paola R, Cuzzocrea S, Siracusa R, Cordaro M., Açai Berry Mitigates Vascular Dementia-Induced Neuropathological Alterations Modulating Nrf-2/Beclin1 Pathways, Cells. 2022 Aug 22;11(16):2616. doi: 10.3390/cells11162616.
Margiani G, Castelli MP, Pintori N, Frau R, Ennas MG, Orrù V, Serra V, Fiorillo E, Fadda P, Marsicano G, De Luca MA., Adolescent self-administration of the synthetic cannabinoid receptor agonist JWH-018 induces neurobiological and behavioral alterations in adult male mice, Psychopharmacology (Berl). 2022 Oct;239(10):3083-3102. doi: 10.1007/s00213-022-06191-9. Epub 2022 Aug 9.
Smith, M. A., Michael, R., Aravindan, R. G., Dash, S., Shah, S. I., Galileo, D. S., & Martin-DeLeon, P. A. (2015)., Anatase titanium dioxide nanoparticles in mice: Evidence for induced structural and functional sperm defects after short-, but not long-, term exposure., Asian Journal of Andrology, 17(2), 261-268. doi:10.4103/1008-682X.143247 [doi]
Kujjo, L. L., Acton, B. M., Perkins, G. A., Ellisman, M. H., D'Estaing, S. G., Casper, R. F., . . . Perez, G. I. (2013)., Ceramide and its transport protein (CERT) contribute to deterioration of mitochondrial structure and function in aging oocytes, Mechanisms of Ageing and Development, 134(1-2), 43-52. doi:10.1016/j.mad.2012.12.001 [doi]
Portal-Nunez, S., Manassra, R., Lozano, D., Acitores, A., Mulero, F., Villanueva-Penacarrillo, M. L., . . . Esbrit, P. (2013)., Characterization of skeletal alterations in a model of prematurely aging mice, Age (Dordrecht, Netherlands), 35(2), 383-393. doi:10.1007/s11357-011-9372-8 [doi]
Torres-Guzman, A. M., Morado-Urbina, C. E., Alvarado-Vazquez, P. A., Acosta-Gonzalez, R. I., Chavez-Pina, A. E., Montiel-Ruiz, R. M., & Jimenez-Andrade, J. M. (2014)., Chronic oral or intraarticular administration of docosahexaenoic acid reduces nociception and knee edema and improves functional outcomes in a mouse model of complete freund's adjuvant-induced knee arthritis, Arthritis Research & Therapy, 16(2), R64. doi:10.1186/ar4502 [doi]
Salloum, F. N., Das, A., Samidurai, A., Hoke, N. N., Chau, V. Q., Ockaili, R. A., . . . Kukreja, R. C. (2012)., Cinaciguat, a novel activator of soluble guanylate cyclase, protects against ischemia/reperfusion injury: Role of hydrogen sulfide, American Journal of Physiology.Heart and Circulatory Physiology, 302(6), H1347-54. doi:10.1152/ajpheart.00544.2011 [doi]
Ben-Meir, A., Burstein, E., Borrego-Alvarez, A., Chong, J., Wong, E., Yavorska, T., . . . Jurisicova, A. (2015)., Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging, Aging Cell, doi:10.1111/acel.12368 [doi]
Babayev E, Suebthawinkul C, Gokyer D, Parkes WS, Rivas F, Pavone ME, Hall AR, Pritchard MT, Duncan FE., Cumulus expansion is impaired with advanced reproductive age due to loss of matrix integrity and reduced hyaluronan., Aging Cell. 2023 Nov;22(11):e14004. doi: 10.1111/acel.14004. Epub 2023 Oct 18.
Schverer M, Donoso F, Mitchell A, Rea K, Fitzgerald P, Sen P, Roy BL, Stanton C, Dinan TG, Cryan JF, Schellekens H., Dietary Milk Phospholipids Attenuate Chronic Stress-Induced Changes in Behavior and Endocrine Responses across the Lifespan, Mol Nutr Food Res. 2022 Feb;66(3):e2100665. doi: 10.1002/mnfr.202100665. Epub 2021 Dec 16.
Cordaro M, D'Amico R, Fusco R, Peritore AF, Genovese T, Interdonato L, Franco G, Arangia A, Gugliandolo E, Crupi R, Siracusa R, Di Paola R, Cuzzocrea S, Impellizzeri D., Discovering the Effects of Fisetin on NF-κB/NLRP-3/NRF-2 Molecular Pathways in a Mouse Model of Vascular Dementia Induced by Repeated Bilateral Carotid Occlusion, Biomedicines. 2022 Jun 19;10(6):1448. doi: 10.3390/biomedicines10061448.
Mihajlovi? AI, Haverfield J, FitzHarris G., Distinct classes of lagging chromosome underpin age-related oocyte aneuploidy in mouse, Dev Cell. 2021 Aug 23;56(16):2273-2283.e3. doi: 10.1016/j.devcel.2021.07.022.
Morado-Urbina, C. E., Alvarado-Vazquez, P. A., Montiel-Ruiz, R. M., Acosta-Gonzalez, R. I., Castaneda-Corral, G., & Jimenez-Andrade, J. M. (2014)., Early, middle, or late administration of zoledronate alleviates spontaneous nociceptive behavior and restores functional outcomes in a mouse model of CFA-induced arthritis., Drug Development Research, 75(7), 438-448. doi:10.1002/ddr.21183 [doi]
Sigurdsson, S., & Gudbjarnason, S. (2013)., Effect of oral imperatorin on memory in mice, Biochemical and Biophysical Research Communications, 441(2), 318-320. doi:10.1016/j.bbrc.2013.10.036 [doi]
Wallace, I. J., Judex, S., & Demes, B. (2015)., Effects of load-bearing exercise on skeletal structure and mechanics differ between outbred populations of mice, Bone, 72, 1-8. doi:10.1016/j.bone.2014.11.013 [doi]
Van Tassell, B. W., Arena, R. A., Toldo, S., Mezzaroma, E., Azam, T., Seropian, I. M., . . . Abbate, A. (2012), Enhanced interleukin-1 activity contributes to exercise intolerance in patients with systolic heart failure, PloS One, 7(3), e33438. doi:10.1371/journal.pone.0033438 [doi]
Weixelbaumer, K. M., Drechsler, S., Wehrenpfennig, P., Khadem, A., Bahrami, S., Tichy, A., . . . Osuchowski, M. F. (2014), Estrus cycle status defined by vaginal cytology does not correspond to fluctuations of circulating estrogens in female mice, Shock (Augusta, Ga.), 41(2), 145-153. doi:10.1097/SHK.0000000000000070 [doi]
Daniels, C. R., Foster, C. R., Yakoob, S., Dalal, S., Joyner, W. L., Singh, M., & Singh, K. (2012)., Exogenous ubiquitin modulates chronic beta-adrenergic receptor-stimulated myocardial remodeling: Role in akt activity and matrix metalloproteinase expression, American Journal of Physiology.Heart and Circulatory Physiology, 303(12), H1459-68. doi:10.1152/ajpheart.00401.2012 [doi]
Liu, P., Huang, Z., & Gu, N. (2013)., Exposure to silver nanoparticles does not affect cognitive outcome or hippocampal neurogenesis in adult mice., Ecotoxicology and Environmental Safety, 87, 124-130. doi:10.1016/j.ecoenv.2012.10.014 [doi]
Shi, X., Wallis, A. M., Gerard, R. D., Voelker, K. A., Grange, R. W., DePinho, R. A., . . . Garry, D. J. (2012)., Foxk1 promotes cell proliferation and represses myogenic differentiation by regulating Foxo4 and Mef2., Journal of Cell Science, 125(Pt 22), 5329-5337. doi:10.1242/jcs.105239 [doi]
Wallace, I. J., Tommasini, S. M., Judex, S., Garland, T.,Jr, & Demes, B. (2012)., Genetic variations and physical activity as determinants of limb bone morphology: An experimental approach using a mouse model., American Journal of Physical Anthropology, 148(1), 24-35. doi:10.1002/ajpa.22028 [doi]
Hasky, N., Uri-Belapolsky, S., Goldberg, K., Miller, I., Grossman, H., Stemmer, S. M., . . . Shalgi, R. (2015)., Gonadotrophin-releasing hormone agonists for fertility preservation: Unraveling the enigma?, Human Reproduction (Oxford, England), 30(5), 1089-1101. doi:10.1093/humrep/dev037 [doi]
Xu, Y., Pan, J., Sun, J., Ding, L., Ruan, L., Reed, M., . . . O'Donnell, J. M. (2015)., Inhibition of phosphodiesterase 2 reverses impaired cognition and neuronal remodeling caused by chronic stress., Neurobiology of Aging, 36(2), 955-970. doi:10.1016/j.neurobiolaging.2014.08.028 [doi]
Ossato, A., Vigolo, A., Trapella, C., Seri, C., Rimondo, C., Serpelloni, G., & Marti, M. (2015). JWH-018 impairs sensorimotor functions in mice., JWH-018 impairs sensorimotor functions in mice., Neuroscience, 300, 174-188. doi:10.1016/j.neuroscience.2015.05.021 [doi]
Beauchamp, B., Ghosh, S., Dysart, M. W., Kanaan, G. N., Chu, A., Blais, A., . . . Harper, M. E. (2015)., Low birth weight is associated with adiposity, impaired skeletal muscle energetics and weight loss resistance in mic, International Journal of Obesity (2005), 39(4), 702-711. doi:10.1038/ijo.2014.120 [doi]
Hamisha, K. N., Tfilin, M., Yanai, J., & Turgeman, G. (2015)., Mesenchymal stem cells can prevent alterations in behavior and neurogenesis induced by Ass25-35 administration., Journal of Molecular Neuroscience : MN, 55(4), 1006-1013. doi:10.1007/s12031-014-0457-6 [doi]
Traina, G., Cataldi, S., Siccu, P., Loreti, E., Ferri, I., Sidoni, A., . . . Albi, E. (2017)., Mouse thyroid gland changes in aging: Implication of galectin-3 and sphingomyelinase., Mediators of Inflammation, 2017, 8102170. doi:10.1155/2017/8102170 [doi]
Dave A, Park EJ, Pezzuto JM., Multi-Organ Nutrigenomic Effects of Dietary Grapes in a Mouse Model., Antioxidants (Basel). 2023 Oct 1;12(10). pii: 1821. doi: 10.3390/antiox12101821.
Cordaro M, Modafferi S, D'Amico R, Fusco R, Genovese T, Peritore AF, Gugliandolo E, Crupi R, Interdonato L, Di Paola D, Impellizzeri D, Cuzzocrea S, Calabrese V, Di Paola R, Siracusa R., Natural Compounds Such as Hericium erinaceus and Coriolus versicolor Modulate Neuroinflammation, Oxidative Stress and Lipoxin A4 Expression in Rotenone-Induced Parkinson's Disease in Mice, Biomedicines. 2022 Oct 7;10(10):2505. doi: 10.3390/biomedicines10102505.
Gammie, S. C., Lee, G., Scotti, M. A., Stevenson, S. A., & Gessay, G. M. (2012)., Neurotensin induced egr-1 activity is altered in the postpartum period in mice, Brain Research, 1433, 47-55. doi:10.1016/j.brainres.2011.11.017 [doi]
Companys-Alemany J, Turcu AL, Schneider M, Müller CE, Vázquez S, Griñán-Ferré C, Pallàs M., NMDA receptor antagonists reduce amyloid-β deposition by modulating calpain-1 signaling and autophagy, rescuing cognitive impairment in 5XFAD mice, Cell Mol Life Sci. 2022 Jul 9;79(8):408. doi: 10.1007/s00018-022-04438-4.
Nahab, F. B., Handforth, A., Brown, T., Shin, C., Quesada, A., Dong, C., . . . Hallett, M. (2012)., Octanoic acid suppresses harmaline-induced tremor in mouse model of essential tremor., Neurotherapeutics : The Journal of the American Society for Experimental NeuroTherapeutics, 9(3), 635-638. doi:10.1007/s13311-012-0121-1 [doi]
Ternianov, A., Perez-Ortiz, J. M., Solesio, M. E., Garcia-Gutierrez, M. S., Ortega-Alvaro, A., Navarrete, F., . . . Manzanares, J. (2012)., Overexpression of CB2 cannabinoid receptors results in neuroprotection against behavioral and neurochemical alterations induced by intracaudate administration of 6-hydroxydopamine., Neurobiology of Aging, 33(2), 421.e1-421.16. doi:10.1016/j.neurobiolaging.2010.09.012 [doi]
Cruz-Pereira JS, Moloney GM, Bastiaanssen TFS, Boscaini S, Tofani G, Borras-Bisa J, van de Wouw M, Fitzgerald P, Dinan TG, Clarke G, Cryan JF., Prebiotic supplementation modulates selective effects of stress on behavior and brain metabolome in aged mice, Neurobiol Stress. 2022 Nov 6;21:100501. doi: 10.1016/j.ynstr.2022.100501. eCollection 2022 Nov.
Melemedjian, O. K., Yassine, H. N., Shy, A., & Price, T. J. (2013)., Proteomic and functional annotation analysis of injured peripheral nerves reveals ApoE as a protein upregulated by injury that is modulated by metformin treatment., Molecular Pain, 9, 14-8069-9-14. doi:10.1186/1744-8069-9-14 [doi]
Dipali SS, King CD, Rose JP, Burdette JE, Campisi J, Schilling B, Duncan FE., Proteomic quantification of native and ECM-enriched mouse ovaries reveals an age-dependent fibro-inflammatory signature., Aging (Albany NY). 2023 Oct 27;15(20):10821-10855. doi: 10.18632/aging.205190. Epub 2023 Oct 27.
Drechsler, S., Weixelbaumer, K., Raeven, P., Jafarmadar, M., Khadem, A., van Griensven, M., . . . Osuchowski, M. F. (2012)., Relationship between age/gender-induced survival changes and the magnitude of inflammatory activation and organ dysfunction in post-traumatic sepsis., PloS One, 7(12), e51457. doi:10.1371/journal.pone.0051457 [doi]
Wiley JL, Barrus DG, Farquhar CE, Lefever TW, Gamage TF., Sex, species and age: Effects of rodent demographics on the pharmacology of ?(9)-tetrahydrocanabinol, Prog Neuropsychopharmacol Biol Psychiatry. 2021 Mar 2;106:110064. doi: 10.1016/j.pnpbp.2020.110064. Epub 2020 Aug 15.
Ben Yaakov T, Wasserman T, Aknin E, Savir Y., Single-cell analysis of the aged ovarian immune system reveals a shift towards adaptive immunity and attenuated cell function., Elife. 2023 Apr 25;12. pii: e74915. doi: 10.7554/eLife.74915.
Shalwala, M., Zhu, S. G., Das, A., Salloum, F. N., Xi, L., & Kukreja, R. C. (2014), Sirtuin 1 (SIRT1) activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in mice, PloS One, 9(1), e86977. doi:10.1371/journal.pone.0086977 [doi]
Ardizzone A, Bova V, Casili G, Filippone A, Campolo M, Lanza M, Esposito E, Paterniti I., SUN11602, a bFGF mimetic, modulated neuroinflammation, apoptosis and calcium-binding proteins in an in vivo model of MPTP-induced nigrostriatal degeneration, J Neuroinflammation. 2022 May 7;19(1):107. doi: 10.1186/s12974-022-02457-3.
Hartmann, U., Hulsmann, H., Seul, J., Roll, S., Midani, H., Breloy, I., . . . Paulsson, M. (2013)., Testican-3: A brain-specific proteoglycan member of the BM-40/SPARC/osteonectin family, Journal of Neurochemistry, 125(3), 399-409. doi:10.1111/jnc.12212 [doi]
Dabbah-Assadi F, Alon D, Golani I, Doron R, Kremer I, Beloosesky R, Shamir A., The influence of immune activation at early vs late gestation on fetal NRG1-ErbB4 expression and behavior in juvenile and adult mice offspring, Brain Behav Immun. 2019 Jul;79:207-215. doi: 10.1016/j.bbi.2019.02.002. Epub 2019 Feb 6.
Lanza M, Cucinotta L, Casili G, Filippone A, Basilotta R, Capra AP, Campolo M, Paterniti I, Cuzzocrea S, Esposito E., The Transcription Factor Nrf2 Mediates the Effects of Antrodia camphorata Extract on Neuropathological Changes in a Mouse Model of Parkinson's Disease., Int J Mol Sci. 2023 May 25;24(11). pii: 9250. doi: 10.3390/ijms24119250.
Miranda, A., Lopez-Cardona, A. P., Laguna-Barraza, R., Calle, A., Lopez-Vidriero, I., Pintado, B., & Gutierrez-Adan, A. (2014)., Transcriptome profiling of liver of non-genetic low birth weight and long term health consequences., BMC Genomics, 15, 327-2164-15-327. doi:10.1186/1471-2164-15-327 [doi]
Kim, J. Y., Ash, R. T., Ceballos-Diaz, C., Levites, Y., Golde, T. E., Smirnakis, S. M., & Jankowsky, J. L. (2013), Viral transduction of the neonatal brain delivers controllable genetic mosaicism for visualising and manipulating neuronal circuits in vivo, The European Journal of Neuroscience, 37(8), 1203-1220. doi:10.1111/ejn.12126 [doi]
Savriama Y, Romestaing C, Clair A, Averty L, Ulmann J, Ledevin R, Renaud S., Wild versus lab house mice: Effects of age, diet, and genetics on molar geometry and topography, J Anat. 2021 Aug 1. doi: 10.1111/joa.13529. Online ahead of print.
Amargant F, Magalhaes C, Pritchard MT, Duncan FE., Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse., Geroscience. 2024 Sep 16. doi: 10.1007/s11357-024-01322-w. [Epub ahead of print]
Hernandez-Benitez R, Wang C, Shi L, Ouchi Y, Zhong C, Hishida T, Liao HK, Magill EA, Memczak S, Soligalla RD, Fresia C, Hatanaka F, Lamas V, Guillen I, Sahu S, Yamamoto M, Shao Y, Aguirre-Vazquez A, Nuñez Delicado E, Guillen P, Rodriguez Esteban C, Qu J, et al., Intervention with metabolites emulating endogenous cell transitions accelerates muscle regeneration in young and aged mice., Cell Rep Med. 2024 Mar 19;5(3):101449. doi: 10.1016/j.xcrm.2024.101449.

COVID-19

Huang WC, Zhou S, He X, Chiem K, Mabrouk MT, Nissly RH, Bird IM, Strauss M, Sambhara S, Ortega J, Wohlfert EA, Martinez-Sobrido L, Kuchipudi SV, Davidson BA, Lovell JF., SARS-CoV-2 RBD Neutralizing Antibody Induction is Enhanced by Particulate Vaccination, Adv Mater. 2020 Oct 28:e2005637. doi: 10.1002/adma.202005637. Online ahead of print.

General studies

Guidi A, Prasanth Saraswati A, Relitti N, Gimmelli R, Saccoccia F, Sirignano C, Taglialatela-Scafati O, Campiani G, Ruberti G, Gemma S., (+)-(R)- and (-)-(S)-Perhexiline maleate: Enantioselective synthesis and functional studies on Schistosoma mansoni larval and adult stages, Bioorg Chem. 2020 Sep;102:104067. doi: 10.1016/j.bioorg.2020.104067. Epub 2020 Jun 30.
Codony S, Pujol E, Pizarro J, Feixas F, Valverde E, Loza MI, Brea JM, Saez E, Oyarzabal J, Pineda-Lucena A, PĂŠrez B, PĂŠrez C, RodrĂ­guez-Franco MI, Leiva R, Osuna S, Morisseau C, Hammock BD, VĂĄzquez-Carrera M, VĂĄzquez S., 2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: In Vivo Evaluation in a Murine Model of Acute Pancreatitis, J Med Chem. 2020 Sep 10;63(17):9237-9257. doi: 10.1021/acs.jmedchem.0c00310. Epub 2020 Aug 25.
Khazma T, Golan-Vaishenker Y, Guez-Haddad J, Grossman A, Sain R, Weitman M, Plotnikov A, Zalk R, Hons M, Opatowsky Y., A duplex structure of SARM1 octamers stabilized by a new inhibitor, Cell Mol Life Sci. 2022 Dec 23;80(1):16. doi: 10.1007/s00018-022-04641-3.
Khazma T, Golan-Vaishenker Y, Guez-Haddad J, Grossman A, Sain R, Weitman M, Plotnikov A, Zalk R, Yaron A, Hons M, Opatowsky Y., A duplex structure of SARM1 octamers stabilized by a new inhibitor., Cell Mol Life Sci. 2022 Dec 23;80(1):16. doi: 10.1007/s00018-022-04641-3. Erratum in: Cell Mol Life Sci. 2023 Feb 23;80(3):68.
Mundaca-Uribe R, Holay M, Abbas A, Askarinam N, Sage-Sepulveda JS, Kubiatowicz L, Fang RH, Zhang L, Wang J., A Microstirring Oral Pill for Improving the Glucose-Lowering Effect of Metformin., ACS Nano. 2023 May 23;17(10):9272-9279. doi: 10.1021/acsnano.3c00581. Epub 2023 May 12.
Colaneri, A., Wang, T., Pagadala, V., Kittur, J., Staffa, N. G.,Jr, Peddada, S. D., . . . Birnbaumer, L. (2013), A minimal set of tissue-specific hypomethylated CpGs constitute epigenetic signatures of developmental programming., PloS One, 8(9), e72670. doi:10.1371/journal.pone.0072670 [doi]
Couch, Y., Xie, Q., Lundberg, L., Sharp, T., & Anthony, D. C. (2015), A model of post-infection fatigue is associated with increased TNF and 5-HT2A receptor expression in mice, PloS One, 10(7), e0130643. doi:10.1371/journal.pone.0130643 [doi]
DebRoy, S., Saldana, M., Travisany, D., Montano, A., Galloway-Pena, J., Horstmann, N., . . . Shelburne, S. A. (2016), A multi-serotype approach clarifies the catabolite control protein A regulon in the major human pathogen group A streptococcus., Scientific Reports, 6, 32442. doi:10.1038/srep32442 [doi]
Kesserwan S, Mao L, Sharafieh R, Kreutzer DL, Klueh U., A pharmacological approach assessing the role of mast cells in insulin infusion site inflammation, Drug Deliv Transl Res. 2021 Sep 24. doi: 10.1007/s13346-021-01070-w. Online ahead of print.
Corbin KL, West HL, Brodsky S, Whitticar NB, Koch WJ, Nunemaker CS., A Practical Guide to Rodent Islet Isolation and Assessment Revisited, Biol Proced Online. 2021 Mar 1;23(1):7. doi: 10.1186/s12575-021-00143-x.
Mwirigi J, Kume M, Hassler SN, Ahmad A, Ray PR, Jiang C, Chamessian A, Mseeh N, Ludwig BP, Rivera BD, Nieman MT, Van de Ven T, Ji RR, Dussor G, Boitano S, Vagner J, Price TJ., A Role for Protease Activated Receptor Type 3 (PAR3) in Nociception Demonstrated Through Development of a Novel Peptide Agonist, J Pain. 2021 Jun;22(6):692-706. doi: 10.1016/j.jpain.2020.12.006. Epub 2021 Jan 9.
Eid Mutlak Y, Aweida D, Volodin A, Ayalon B, Dahan N, Parnis A, Cohen S., A signaling hub of insulin receptor, dystrophin glycoprotein complex and plakoglobin regulates muscle size, Nat Commun. 2020 Mar 13;11(1):1381. doi: 10.1038/s41467-020-14895-9.
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Ren A, Hu J, Qin C, Xia N, Yu M, Xu X, Yang H, Han M, Zhang L, Ma L., Oral administration microrobots for drug delivery., Bioact Mater. 2024 May 21;39:163-190. doi: 10.1016/j.bioactmat.2024.05.005. eCollection 2024 Sep. Review.
Shiau JC, Garcia-Diaz N, Kyle DE, Pathak AK., The influence of oviposition status on measures of transmission potential in malaria-infected mosquitoes depends on sugar availability., Parasit Vectors. 2024 May 23;17(1):236. doi: 10.1186/s13071-024-06317-2.
Zhu Y, Kratka CR, Pea J, Lee HC, Kratka CE, Xu J, Marin D, Treff NR, Duncan FE., The severity of meiotic aneuploidy is associated with altered morphokinetic variables of mouse oocyte maturation., Hum Reprod Open. 2024 Apr 23;2024(2):hoae023. doi: 10.1093/hropen/hoae023. eCollection 2024.
Danino YM, Rabinovitz R, Kirshenboim I, Palzur E, Pick CG, Ish-Shalom I, Golovkin Y, Arieli Y., Exposure to hyperbaric O(2) levels leads to blood-brain barrier breakdown in rodents., Fluids Barriers CNS. 2024 May 16;21(1):41. doi: 10.1186/s12987-024-00543-7.
Kharel Y, Huang T, Dunnavant K, Foster D, Souza G, Nimchuk KE, Merchak AR, Pavelec CM, Juskiewicz ZJ, Gaultier A, Abbott S, Shin JB, Isakson BE, Xu W, Leitinger N, Santos WL, Lynch KR., Assessing Spns2-dependent S1P Transport as a Prospective Therapeutic Target., bioRxiv. 2024 Apr 30. pii: 2024.03.26.586765. doi: 10.1101/2024.03.26.586765.
Zhan T, Zhang J, Zhang Y, Zhao Q, Chemerinski A, Douglas NC, Zhang Q, Xiao S., A Dose-Response Study on Functional and Transcriptomic Effects of FSH on Ex Vivo Mouse Folliculogenesis., Endocrinology. 2024 May 27;165(7). doi: 10.1210/endocr/bqae054.
Ali N, Lunenfeld E, Huleihel M., Effect of IL-1β on the Development of Spermatogenesis In Vitro in Normal and Busulfan-Treated Immature Mice., Int J Mol Sci. 2024 Apr 30;25(9). doi: 10.3390/ijms25094926.
Buzzi B, AlSharari SD, Walentiny DM, Damaj MI., Nelotanserin, a selective 5-HT2A receptor inverse agonist, attenuates aspects of nicotine withdrawal but not reward in mice., Behav Brain Res. 2024 Jun 5;467:115019. doi: 10.1016/j.bbr.2024.115019. Epub 2024 Apr 25.
Karin KN, Mustafa MA, Poklis JL, Buzzi B, Schlosburg JE, Parker L, Damaj MI, Lichtman AH., N-oleoyl alanine attenuates nicotine reward and spontaneous nicotine withdrawal in mice., Drug Alcohol Depend. 2024 Jun 1;259:111276. doi: 10.1016/j.drugalcdep.2024.111276. Epub 2024 Apr 4.
Repici A, Capra AP, Hasan A, Bulzomì M, Campolo M, Paterniti I, Esposito E, Ardizzone A., Novel Findings on CCR1 Receptor in CNS Disorders: A Pathogenic Marker Useful in Controlling Neuroimmune and Neuroinflammatory Mechanisms in Parkinson's Disease., Int J Mol Sci. 2024 Apr 14;25(8). doi: 10.3390/ijms25084337.
Krupp KT, Yaeger JDW, Ledesma LJ, Withanage MHH, Gale JJ, Howe CB, Allen TJ, Sathyanesan M, Newton SS, Summers CH., Single administration of a psychedelic [(R)-DOI] influences coping strategies to an escapable social stress., Neuropharmacology. 2024 Jul 1;252:109949. doi: 10.1016/j.neuropharm.2024.109949. Epub 2024 Apr 16.
Santos EJ, Akbarali HI, Bow EW, Chambers DR, Gutman ES, Jacobson AE, Kang M, Lee YK, Lutz JA, Rice KC, Sulima A, Negus SS., Low-Efficacy Mu Opioid Agonists as Candidate Analgesics: Effects of Novel C-9 Substituted Phenylmorphans on Pain-Depressed Behavior in Mice., J Pharmacol Exp Ther. 2024 Oct 18;391(2):138-151. doi: 10.1124/jpet.124.002153.
Shrivastav AM, Ali N, Singh N, Lunenfeld E, Abdulhalim I, Huleihel M., Identification of spermatogenesis in individual seminiferous tubules and testicular tissue of adult normal and busulfan-treated mice employing Raman spectroscopy and principal component analysis., Spectrochim Acta A Mol Biomol Spectrosc. 2024 Jul 5;315:124232. doi: 10.1016/j.saa.2024.124232. Epub 2024 Mar 31.
Matteo C, Orienti I, Eramo A, Zeuner A, Ferrari M, Passoni A, Bagnati R, Ponzo M, Bello E, Zucchetti M, Frapolli R., Validated LC-MS/MS Assay for the Quantitative Determination of Fenretinide in Plasma and Tumor and Its Application in a Pharmacokinetic Study in Mice of a Novel Oral Nanoformulation of Fenretinide., Pharmaceutics. 2024 Mar 12;16(3). doi: 10.3390/pharmaceutics16030387.
Gonye EC, Dagli AV, Kumar NN, Clements RT, Xu W, Bayliss DA., Expression of endogenous epitope-tagged GPR4 in the mouse brain., eNeuro. 2024 Feb 26;11(3). pii: ENEURO.0002-24.2024. doi: 10.1523/ENEURO.0002-24.2024. [Epub ahead of print]
Gabbay V, Ely B, Vileisis J, Petrovic Z, Cicvaric A, Asnis G, Kim-Schulze S, Radulovic J., Immune and Neural Response to Acute Social Stress in Adolescent Humans and Rodents., Res Sq. 2024 Feb 5. pii: rs.3.rs-3845793. doi: 10.21203/rs.3.rs-3845793/v1. Update in: Transl Psychiatry. 2024 Jul 25;14(1):306. doi: 10.1038/s41398-024-03008-5..
Churchill CC, Peterson CD, Kitto KF, Pflepsen KR, Belur LR, McIvor RS, Vulchanova L, Wilcox GL, Fairbanks CA., Adeno-associated virus-mediated gene transfer of arginine decarboxylase to the central nervous system prevents opioid analgesic tolerance., Front Pain Res (Lausanne). 2024 Feb 9;4:1269017. doi: 10.3389/fpain.2023.1269017. eCollection 2023.
Diester CM, Balint H, Gillespie JC, Lichtman AH, Sim-Selley LJ, Selley DE, Negus SS., Effects of Repeated Treatment with the Monoacylglycerol Lipase Inhibitor MJN110 on Pain-Related Depression of Nesting and Cannabinoid 1 Receptor Function in Male and Female Mice., J Pharmacol Exp Ther. 2024 Aug 19;390(3):291-301. doi: 10.1124/jpet.123.001940.
Ardizzone A, Capra AP, Repici A, Lanza M, Bova V, Palermo N, Paterniti I, Esposito E., Rebalancing NOX2/Nrf2 to limit inflammation and oxidative stress across gut-brain axis in migraine., Free Radic Biol Med. 2024 Mar;213:65-78. doi: 10.1016/j.freeradbiomed.2024.01.018. Epub 2024 Jan 19.
Renaud S, Amar L, Chevret P, Romestaing C, Quéré JP, Régis C, Lebrun R., Inner ear morphology in wild versus laboratory house mice., J Anat. 2024 May;244(5):722-738. doi: 10.1111/joa.13998. Epub 2024 Jan 12.
Liu K, Zhao C, Adajar RC, DeZwaan-McCabe D, Rutkowski DT., A beneficial adaptive role for CHOP in driving cell fate selection during ER stress., EMBO Rep. 2024 Jan;25(1):228-253. doi: 10.1038/s44319-023-00026-0. Epub 2024 Jan 2.
Wang S, Matsumoto K, Mehlferber MM, Zhang G, Aronova MA, Yamada KM., Microtubule-dependent apical polarization of basement membrane matrix mRNAs in mouse epithelial cells., Cells Dev. 2024 Mar;177:203898. doi: 10.1016/j.cdev.2023.203898. Epub 2023 Dec 14.
Hill TG, Smith LIF, Ruz-Maldonado I, Jones PM, Bowe JE., Kisspeptin upregulates β-cell serotonin production during pregnancy., J Endocrinol. 2023 Dec 18;260(2). pii: e230218. doi: 10.1530/JOE-23-0218. Print 2024 Feb 1.
Dinur E, Goldenberg H, Robinson E, Naggan L, Kozela E, Yirmiya R., A Novel Anti-Inflammatory Formulation Comprising Celecoxib and Cannabidiol Exerts Antidepressant and Anxiolytic Effects., Cannabis Cannabinoid Res. 2024 Apr;9(2):561-580. doi: 10.1089/can.2022.0225. Epub 2022 Dec 14.

Infectious disease

Guo XP, Yan HQ, Yang W, Yin Z, Vadyvaloo V, Zhou D, Sun YC., A frameshift in Yersinia pestis rcsD alters canonical Rcs signalling to preserve flea-mammal plague transmission cycles., Elife. 2023 Apr 3;12. pii: e83946. doi: 10.7554/eLife.83946.
Andes DR, Nett JE., Analysis of Candida Antifungal Resistance Using Animal Infection Models., Methods Mol Biol. 2023;2658:225-238. doi: 10.1007/978-1-0716-3155-3_16.
Szebenyi C, Gu Y, Gebremariam T, Kocsubé S, Kiss-Vetráb S, Jáger O, Patai R, Spisák K, Sinka R, Binder U, Homa M, Vágvölgyi C, Ibrahim AS, Nagy G, Papp T., cotH Genes Are Necessary for Normal Spore Formation and Virulence in Mucor lusitanicus., mBio. 2023 Feb 28;14(1):e0338622. doi: 10.1128/mbio.03386-22. Epub 2023 Jan 10.
Heida R, Akkerman R, Jacob Silva PH, Lakerveld AJ, Ortiz D, Bigogno C, Gasbarri M, van Kasteren PB, Stellacci F, Frijlink HW, Huckriede ALW, Hinrichs WLJ., Development of an inhalable antiviral powder formulation against respiratory syncytial virus., J Control Release. 2023 May;357:264-273. doi: 10.1016/j.jconrel.2023.03.059. Epub 2023 Apr 5.
Casselli T, Tourand Y, Gura K, Stevenson B, Zückert WR, Brissette CA., Endogenous Linear Plasmids lp28-4 and lp25 Are Required for Infectivity and Restriction Protection in the Lyme Disease Spirochete Borrelia mayonii., Infect Immun. 2023 Mar 15;91(3):e0006123. doi: 10.1128/iai.00061-23. Epub 2023 Feb 28.
Thiriot J, Liang Y, Fisher J, Walker DH, Soong L., Host transcriptomic profiling of CD-1 outbred mice with severe clinical outcomes following infection with Orientia tsutsugamushi, PLoS Negl Trop Dis. 2022 Nov 23;16(11):e0010459. doi: 10.1371/journal.pntd.0010459. eCollection 2022 Nov.
Dabbah-Assadi F, Rashid S, Golani I, Rubinstein A, Doron R, Alon D, Palzur E, Beloosesky R, Shamir A., Long-term effects of prophylactic MgSO(4) in maternal immune activation rodent model at adolescence and adulthood, J Neurosci Res. 2023 Mar;101(3):316-326. doi: 10.1002/jnr.25148. Epub 2022 Nov 26.
Gao J, Su Y, Wang Z., Remote Co-loading of amphipathic acid drugs in neutrophil nanovesicles infilled with cholesterol mitigates lung bacterial infection and inflammation., Biomaterials. 2023 May;296:122071. doi: 10.1016/j.biomaterials.2023.122071. Epub 2023 Feb 28.
Walker JM, Sundarasivarao PYK, Thornton JM, Sochacki K, Rodriguez A, Spur BW, Acharya NK, Yin K., Resolvin D2 promotes host defense in a 2 - hit model of sepsis with secondary lung infection, Prostaglandins Other Lipid Mediat. 2022 Apr;159:106617. doi: 10.1016/j.prostaglandins.2022.106617. Epub 2022 Jan 8.
Huang WC, Zhou S, He X, Chiem K, Mabrouk MT, Nissly RH, Bird IM, Strauss M, Sambhara S, Ortega J, Wohlfert EA, Martinez-Sobrido L, Kuchipudi SV, Davidson BA, Lovell JF., SARS-CoV-2 RBD Neutralizing Antibody Induction is Enhanced by Particulate Vaccination, Adv Mater. 2020 Oct 28:e2005637. doi: 10.1002/adma.202005637. Online ahead of print.
Eraso JM, Olsen RJ, Long SW, Gadd R, Boukthir S, Faili A, Kayal S, Musser JM., Integrative genomic, virulence, and transcriptomic analysis of emergent Streptococcus dysgalactiae subspecies equisimilis (SDSE) emm type stG62647 isolates causing human infections., mBio. 2024 Nov 13;15(11):e0257824. doi: 10.1128/mbio.02578-24. Epub 2024 Oct 17.
Wiederhold NP, Najvar LK, Jaramillo R, Olivo M, Larwood DJ, Patterson TF., Evaluation of nikkomycin Z with frequent oral administration in an experimental model of central nervous system coccidioidomycosis., Microbiol Spectr. 2024 Oct 3;12(10):e0135624. doi: 10.1128/spectrum.01356-24. Epub 2024 Aug 20.
Hallenbeck M, Chua M, Collins J., The role of the universal sugar transport system components PtsI (EI) and PtsH (HPr) in Enterococcus faecium., FEMS Microbes. 2024 Jun 3;5:xtae018. doi: 10.1093/femsmc/xtae018. eCollection 2024.
Huang WC, Baker WS, Lovell JF, Schein CH., Displaying alphavirus physicochemical consensus antigens on immunogenic liposomes enhances antibody elicitation in mice., Virology. 2024 Sep;597:110152. doi: 10.1016/j.virol.2024.110152. Epub 2024 Jun 20.
Bernabè G, Castagliuolo I, Porzionato A, Casarotto G, Monte RD, Carpi A, Brun P., Insoluble polysaccharides produced in plant cell cultures protect from Clostridioides difficile colitis., Microbiol Res. 2024 Sep;286:127812. doi: 10.1016/j.micres.2024.127812. Epub 2024 Jun 22.
Huang W-C, Eberle K, Colon JR, Lovell JF, Xin H., Liposomal Fba and Met6 peptide vaccination protects mice from disseminated candidiasis., mSphere. 2024 Jul 30;9(7):e0018924. doi: 10.1128/msphere.00189-24. Epub 2024 Jun 21.
Parthasarathy S, Saenjamsai P, Hao H, Ferkul A, Pfannenstiel JJ, Suder EL, Bejan DS, Chen Y, Schwarting N, Aikawa M, Muhlberger E, Orozco RC, Sullivan CS, Cohen MS, Davido DJ, Hume AJ, Fehr AR., PARP14 is pro- and anti-viral host factor that promotes IFN production and affects the replication of multiple viruses., bioRxiv. 2024 Apr 26. pii: 2024.04.26.591186. doi: 10.1101/2024.04.26.591186.
Gu Y, Gebremariam T, Alkhazraji S, Youssef E, El-Gamal S, Matkovits T, Cobb J, Mannino R, Ibrahim AS., Efficacy of an oral lipid nanocrystal formulation of amphotericin B (MAT2203) in the neutropenic mouse model of pulmonary mucormycosis., Antimicrob Agents Chemother. 2024 Jun 5;68(6):e0154023. doi: 10.1128/aac.01540-23. Epub 2024 Apr 30.
Muchhala KH, Kallurkar PS, Kang M, Koseli E, Poklis JL, Xu Q, Dewey WL, Fettweis JM, Jimenez NR, Akbarali HI., The role of morphine- and fentanyl-induced impairment of intestinal epithelial antibacterial activity in dysbiosis and its impact on the microbiota-gut-brain axis., FASEB J. 2024 Apr 30;38(8):e23603. doi: 10.1096/fj.202301590RR.
Miller WR, Nguyen A, Singh KV, Rizvi S, Khan A, Erickson SG, Egge SL, Cruz M, Dinh AQ, Diaz L, Thornton PC, Zhang R, Xu L, Garsin DA, Shamoo Y, Arias CA., Membrane Lipids Augment Cell Envelope Stress Signaling via the MadRS System to Defend Against Antimicrobial Peptides and Antibiotics in Enterococcus faecalis., J Infect Dis. 2024 Apr 5. pii: jiae173. doi: 10.1093/infdis/jiae173. [Epub ahead of print]
Gebremariam T, Alkhazraji S, Gu Y, Najvar LK, Borroto-Esoda K, Patterson TF, Filler SG, Wiederhold NP, Ibrahim AS., Ibrexafungerp is efficacious in a neutropenic murine model of pulmonary mucormycosis as monotherapy and combined with liposomal amphotericin B., Antimicrob Agents Chemother. 2024 May 2;68(5):e0154523. doi: 10.1128/aac.01545-23. Epub 2024 Apr 1.
Wakade RS, Wellington M, Krysan DJ., The role of the C. albicans transcriptional repressor NRG1 during filamentation and disseminated candidiasis is strain dependent., mSphere. 2024 Mar 26;9(3):e0078523. doi: 10.1128/msphere.00785-23. Epub 2024 Feb 20.
Vander Elst N, Bellemans J, Lavigne R, Briers Y, Meyer E., Endolysin NC5 improves early cloxacillin treatment in a mouse model of Streptococcus uberis mastitis., Appl Microbiol Biotechnol. 2024 Dec;108(1):118. doi: 10.1007/s00253-023-12820-w. Epub 2024 Jan 10.

Oncology

Tremmel, Lisa; Rho, Okkyung; Slaga, Thomas J; DiGiovanni, John;, Inhibition of skin tumor promotion by TPA using a combination of topically applied ursolic acid and curcumin., Molecular carcinogenesis Vol.58, 2019
de la Fuente, M., Jones, M. C., Santander-Ortega, M. J., Mirenska, A., Marimuthu, P., Uchegbu, I., & Schatzlein, A. (2015)., A nano-enabled cancer-specific ITCH RNAi chemotherapy booster for pancreatic cancer., Nanomedicine : Nanotechnology, Biology, and Medicine, 11(2), 369-377. doi:10.1016/j.nano.2014.09.010 [doi]
Qiu, X., Liang, Y., Sellers, R. S., Perez-Soler, R., & Zou, Y. (2014)., Aerosol azacytidine inhibits orthotopic lung cancers in mice through its DNA demethylation and gene reactivation effects., PloS One, 9(10), e109874. doi:10.1371/journal.pone.0109874 [doi]
Frosina, G., Profumo, A., Marubbi, D., Marcello, D., Ravetti, J. L., & Daga, A. (2018)., ATR kinase inhibitors NVP-BEZ235 and AZD6738 effectively penetrate the brain after systemic administration, Radiation Oncology (London, England), 13(1), 76-018-1020-3. doi:10.1186/s13014-018-1020-3 [doi]
Airouche S, Beltrami V, Fleury S, Batard T, Bordas-Le Floch V, Stegmann T, Amacker M, Kettner A, Mascarell L., Bet v 1 contiguous overlapping peptides anchored to virosomes with TLR4 agonist enhance immunotherapy efficacy in mice, Clin Exp Allergy. 2021 Feb;51(2):339-349. doi: 10.1111/cea.13814. Epub 2021 Jan 6.
Oliveira, H., Lopes, T., Almeida, T., Pereira Mde, L., & Santos, C. (2012), Cadmium-induced genetic instability in mice testis, Human & Experimental Toxicology, 31(12), 1228-1236. doi:10.1177/0960327112445937 [doi]
Smith, M. C., Mader, M. M., Cook, J. A., Iversen, P., Ajamie, R., Perkins, E., . . . Wacheck, V. (2016)., Characterization of LY3023414, a novel PI3K/mTOR dual inhibitor eliciting transient target modulation to impede tumor growth, Molecular Cancer Therapeutics, 15(10), 2344-2356. doi:1535-7163.MCT-15-0996 [pii]
Aviello, G., Romano, B., Borrelli, F., Capasso, R., Gallo, L., Piscitelli, F., . . . Izzo, A. A. (2012)., Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer., Journal of Molecular Medicine (Berlin, Germany), 90(8), 925-934. doi:10.1007/s00109-011-0856-x [doi]
Gridley, D. S., Freeman, T. L., Makinde, A. Y., Wroe, A. J., Luo-Owen, X., Tian, J., . . . Pecaut, M. J. (2011), Comparison of proton and electron radiation effects on biological responses in liver, spleen and blood., International Journal of Radiation Biology, 87(12), 1173-1181. doi:10.3109/09553002.2011.624393 [doi]
Arantes-Rodrigues, R., Pinto-Leite, R., da Costa, R. G., Colaco, A., Lopes, C., & Oliveira, P. (2013)., Cytogenetic characterization of an N-butyl-N-(4-hydroxybutyl) nitrosamine-induced mouse papillary urothelial carcinoma., Tumour Biology : The Journal of the International Society for Oncodevelopmental Biology and Medicine, 34(5), 2691-2696. doi:10.1007/s13277-013-0820-1 [doi]
Santos, N. P., Oliveira, P. A., Arantes-Rodrigues, R., Faustino-Rocha, A. I., Colaco, A., Lopes, C., & Gil da Costa, R. M. (2014)., Cytokeratin 7/19 expression in N-diethylnitrosamine-induced mouse hepatocellular lesions: Implications for histogenesis., International Journal of Experimental Pathology, 95(3), 191-198. doi:10.1111/iep.12082 [doi]
Sengar, P., Juarez, P., Verdugo-Meza, A., Arellano, D. L., Jain, A., Chauhan, K., . . . Fournier, P. G. J. (2018)., Development of a functionalized UV-emitting nanocomposite for the treatment of cancer using indirect photodynamic therapy., Journal of Nanobiotechnology, 16(1), 19-018-0344-3. doi:10.1186/s12951-018-0344-3 [doi]
Nachliely, Matan; Trachtenberg, Aviram; Khalfin, Boris; Nalbandyan, Karen; Cohen-Lahav, Merav; Yasuda, Kaori; Sakaki, Toshiyuki; Kutner, Andrzej; Danilenko, Michael;, Dimethyl fumarate and vitamin D derivatives cooperatively enhance VDR and Nrf2 signaling in differentiating AML cells in vitro and inhibit leukemia progression in a xenograft mouse model., The Journal of steroid biochemistry and molecular biology Vol.188, 2019
Procopiou G, Jackson PJM, di Mascio D, Auer JL, Pepper C, Rahman KM, Fox KR, Thurston DE., DNA sequence-selective G-A cross-linking ADC payloads for use in solid tumour therapies, Commun Biol. 2022 Jul 29;5(1):741. doi: 10.1038/s42003-022-03633-0.
Beziere, N., Lozano, N., Nunes, A., Salichs, J., Queiros, D., Kostarelos, K., & Ntziachristos, V. (2015)., Dynamic imaging of PEGylated indocyanine green (ICG) liposomes within the tumor microenvironment using multi-spectral optoacoustic tomography (MSOT), Biomaterials, 37, 415-424. doi:10.1016/j.biomaterials.2014.10.014 [doi]
Vasconcelos-Nobrega, C., Costa, C., Vala, H., Colaco, A., Santos, L., Lopes, C., & Oliveira, P. A. (2013), E-cadherin and beta-catenin expression during urothelial carcinogenesis induced by N-butyl-N-(4-hydroxybutyl) nitrosamine in mice., Urologia Internationalis, 91(4), 462-466. doi:10.1159/000348329 [doi]
Cho, J., Rho, O., Junco, J., Carbajal, S., Siegel, D., Slaga, T. J., & DiGiovanni, J. (2015)., Effect of combined treatment with ursolic acid and resveratrol on skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate., Cancer Prevention Research (Philadelphia, Pa.), 8(9), 817-825. doi:10.1158/1940-6207.CAPR-15-0098 [doi]
Dogan, S., Johannsen, A. C., Grande, J. P., & Cleary, M. P. (2011)., Effects of intermittent and chronic calorie restriction on mammalian target of rapamycin (mTOR) and IGF-I signaling pathways in mammary fat pad tissues and mammary tumors., Nutrition and Cancer, 63(3), 389-401. doi:10.1080/01635581.2011.535968 [doi]
Hao, E., Lee, S. H., & Levine, F. (2013)., Efficient beta-cell regeneration by a combination of neogenesis and replication following beta-cell ablation and reversal of pancreatic duct ligation., Stem Cells (Dayton, Ohio), 31(11), 2388-2395. doi:10.1002/stem.1492 [doi]
Moore, T., Beltran, L., Carbajal, S., Hursting, S. D., & DiGiovanni, J. (2012)., Energy balance modulates mouse skin tumor promotion through altered IGF-1R and EGFR crosstalk., Cancer Prevention Research (Philadelphia, Pa.), 5(10), 1236-1246. doi:10.1158/1940-6207.CAPR-12-0234 [doi]
Holtz, B. J., Lodewyk, K. B., Sebolt-Leopold, J. S., Ernst, S. A., & Williams, J. A. (2014)., ERK activation is required for CCK-mediated pancreatic adaptive growth in mice., American Journal of Physiology.Gastrointestinal and Liver Physiology, 307(7), G700-10. doi:10.1152/ajpgi.00163.2014 [doi]
Vasconcelos-Nobrega, C., Colaco, A., Santos, L., Vala, H., Palomino, L. F., Lopes, C., & Oliveira, P. A. (2011)., Experimental study of the anticancer effect of gemcitabine combined with sirolimus on chemically induced urothelial lesions., Anticancer Research, 31(5), 1637-1642. doi:31/5/1637 [pii]
Celik, H., Bulut, G., Han, J., Graham, G. T., Minas, T. Z., Conn, E. J., . . . Uren, A. (2016)., Ezrin inhibition up-regulates stress response gene expression., The Journal of Biological Chemistry, 291(25), 13257-13270. doi:10.1074/jbc.M116.718189 [doi]
Oren, R., Addadi, Y., Narunsky Haziza, L., Dafni, H., Rotkopf, R., Meir, G., . . . Neeman, M. (2016)., Fibroblast recruitment as a tool for ovarian cancer detection and targeted therapy., International Journal of Cancer, 139(8), 1788-1798. doi:10.1002/ijc.30209 [doi]
Nakagawa, R., Vukovic, M., Tarafdar, A., Cosimo, E., Dunn, K., McCaig, A. M., . . . Michie, A. M. (2015)., Generation of a poor prognostic chronic lymphocytic leukemia-like disease model: PKCalpha subversion induces up-regulation of PKCbetaII expression in B lymphocytes., Haematologica, 100(4), 499-510. doi:10.3324/haematol.2014.112276 [doi]
Taiarol L, Bigogno C, Sesana S, Kravicz M, Viale F, Pozzi E, Monza L, Carozzi VA, Meregalli C, Valtorta S, Moresco RM, Koch M, Barbugian F, Russo L, Dondio G, Steinkühler C, Re F., Givinostat-Liposomes: Anti-Tumor Effect on 2D and 3D Glioblastoma Models and Pharmacokinetics, Cancers (Basel). 2022 Jun 16;14(12):2978. doi: 10.3390/cancers14122978.
Piao, L., Li, H., Teng, L., Yung, B. C., Sugimoto, Y., Brueggemeier, R. W., & Lee, R. J. (2013), Human serum albumin-coated lipid nanoparticles for delivery of siRNA to breast cancer., Nanomedicine : Nanotechnology, Biology, and Medicine, 9(1), 122-129. doi:10.1016/j.nano.2012.03.008 [doi]
Krivokrysenko, V. I., Shakhov, A. N., Singh, V. K., Bone, F., Kononov, Y., Shyshynova, I., . . . Feinstein, E. (2012)., Identification of granulocyte colony-stimulating factor and interleukin-6 as candidate biomarkers of CBLB502 efficacy as a medical radiation countermeasure., The Journal of Pharmacology and Experimental Therapeutics, 343(2), 497-508. doi:10.1124/jpet.112.196071 [doi]
Cressey P, Amrahli M, So PW, Gedroyc W, Wright M, Thanou M., Image-guided thermosensitive liposomes for focused ultrasound enhanced co-delivery of carboplatin and SN-38 against triple negative breast cancer in mice, Biomaterials. 2021 Apr;271:120758. doi: 10.1016/j.biomaterials.2021.120758. Epub 2021 Mar 16.
Vasconcelos-Nobrega, C., Pinto-Leite, R., Arantes-Rodrigues, R., Ferreira, R., Brochado, P., Cardoso, M. L., . . . Oliveira, P. A. (2013)., In vivo and in vitro effects of RAD001 on bladder cancer., Urologic Oncology, 31(7), 1212-1221. doi:10.1016/j.urolonc.2011.11.002 [doi]
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Teratology

Lee HC, Balough JL, Roth EW, Vaccari S, Duncan FE., A decellularized oocyte-derived scaffold provides a "sperm safe" to preserve mammalian spermatozoa, Andrology. 2021 May;9(3):922-932. doi: 10.1111/andr.12986. Epub 2021 Mar 5.
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Pericuesta E, Laguna-Barraza R, Ramos-Ibeas P, Gutierrez-Arroyo JL, Navarro JA, Vera K, Sanjuan C, Baixeras E, de Fonseca FR, Gutierrez-Adan A., D-Chiro-Inositol Treatment Affects Oocyte and Embryo Quality and Improves Glucose Intolerance in Both Aged Mice and Mouse Models of Polycystic Ovarian Syndrome, Int J Mol Sci. 2020 Aug 22;21(17):6049. doi: 10.3390/ijms21176049.
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Iijima, Y., Behr, K., Iijima, T., Biemans, B., Bischofberger, J., & Scheiffele, P. (2016)., Distinct defects in synaptic differentiation of neocortical neurons in response to prenatal valproate exposure, Scientific Reports, 6, 27400. doi:10.1038/srep27400 [doi]
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Tartaglione, Anna Maria; Cipriani, Chiara; Chiarotti, Flavia; Perrone, Benedetta; Balestrieri, Emanuela; Matteucci, Claudia; Sinibaldi-Vallebona, Paola; Calamandrei, Gemma; Ricceri, Laura;, Early Behavioral Alterations and Increased Expression of Endogenous Retroviruses Are Inherited Across Generations in Mice Prenatally Exposed to Valproic Acid., Molecular neurobiology Vol.56, 2019
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Tsai, J. H., Chi, M. M., Schulte, M. B., & Moley, K. H. (2014)., he fatty acid beta-oxidation pathway is important for decidualization of endometrial stromal cells in both humans and mice, Biology of Reproduction, 90(2), 34. doi:10.1095/biolreprod.113.113217 [doi]
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Kusuhara A, Babayev E, Zhou LT, Singh VP, Gerton JL, Duncan FE., Immature Follicular Origins and Disrupted Oocyte Growth Pathways Contribute to Decreased Gamete Quality During Reproductive Juvenescence in Mice, Front Cell Dev Biol. 2021 Jun 16;9:693742. doi: 10.3389/fcell.2021.693742. eCollection 2021.
Warner, D. R., Smith, S. C., Smolenkova, I. A., Pisano, M. M., & Greene, R. M. (2016), Inhibition of p300 histone acetyltransferase activity in palate mesenchyme cells attenuates wnt signaling via aberrant E-cadherin expression, Experimental Cell Research, 342(1), 32-38. doi:10.1016/j.yexcr.2016.02.015 [doi]
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Luo F, Xing C, Asrani SK, Li S, Liang G, Hobbs HH, Cohen JC., Missense variant in insulin receptor (Y1355H) segregates in family with fatty liver disease, Mol Metab. 2021 Nov;53:101299. doi: 10.1016/j.molmet.2021.101299. Epub 2021 Jul 13.
Marchini, Marta; Silva Hernandez, Elizabeth; Rolian, Campbell;, Morphology and development of a novel murine skeletal dysplasia., PeerJ Vol.7, 2019
Blankenship, J. R., Cheng, S., Woolford, C. A., Xu, W., Johnson, T. M., Rogers, P. D., . . . Mitchell, A. P. (2014), Mutational analysis of essential septins reveals a role for septin-mediated signaling in filamentation., Eukaryotic Cell, 13(11), 1403-1410. doi:10.1128/EC.00127-14 [doi]
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Pericuesta E, Gutiérrez-Arroyo JL, Sánchez-Calabuig MJ, Gutiérrez-Adán A., Postnatal Catch-Up Growth Programs Telomere Dynamics and Glucose Intolerance in Low Birth Weight Mice, Int J Mol Sci. 2021 Apr 1;22(7):3657. doi: 10.3390/ijms22073657.
West HL, Corbin KL, D'Angelo CV, Donovan LM, Jahan I, Gu G, Nunemaker CS., Postnatal maturation of calcium signaling in islets of Langerhans from neonatal mice, Cell Calcium. 2021 Mar;94:102339. doi: 10.1016/j.ceca.2020.102339. Epub 2020 Dec 28.
Tan H, Wu G, Wang S, Lawless J, Sinn A, Chen D, Zheng Z., Prenatal exposure to atrazine induces cryptorchidism and hypospadias in F1 male mouse offspring, Birth Defects Res. 2021 Apr 1;113(6):469-484. doi: 10.1002/bdr2.1865. Epub 2021 Jan 19.
Shashar, Moshe; Zubkov, Asia; Chernichovski, Tamara; Hershkovitz, Rami; Hoffman, Elinoar; Grupper, Ayelet; Weinstein, Talia; Schwartz, Idit F;, Profound Decrease in Glomerular Arginine Transport by CAT (Cationic Amino Acid Transporter)-1 Contributes to the FLT-1 (FMS-Like Tyrosine Kinase 1) Induced Preeclampsia in the Pregnant Mice., Hypertension (Dallas, Tex. : 1979) Vol.73, 2019
Gutzeit, O., Segal, L., Hertz, R., Burke, Y., Paz, G., Hantisteanu, S., Ginsberg, Y., Hallak, M., Pencovich, N., Beloosesky, R., Weine,r Z., & Fainaru, O. (2018)., Progesterone treatment enhances the expansion of placental immature myeloid cells in a mouse model of premature labor, J Reprod Immunol, 131, 7-12. doi: 10.1016/j.jri.2018.10.003. [doi]
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Bagdadi N, Sawaied A, AbuMadighem A, Lunenfeld E, Huleihel M., The Expression Levels and Cellular Localization of Pigment Epithelium Derived Factor (PEDF) in Mouse Testis: Its Possible Involvement in the Differentiation of Spermatogonial Cells, Int J Mol Sci. 2021 Jan 24;22(3):1147. doi: 10.3390/ijms22031147.
Tsai, J. H., Chi, M. M., Schulte, M. B., & Moley, K. H. (2014)., The fatty acid beta-oxidation pathway is important for decidualization of endometrial stromal cells in both humans and mice, Biology of Reproduction, 90(2), 34. doi:10.1095/biolreprod.113.113217 [doi]
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Toxicology

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Genovese T, Duranti A, D'Amico R, Fusco R, Impellizzeri D, Peritore AF, Crupi R, Gugliandolo E, Cuzzocrea S, Di Paola R, Siracusa R, Cordaro M., Fatty Acid Amide Hydrolase (FAAH) Inhibition Plays a Key Role in Counteracting Acute Lung Injury, Int J Mol Sci. 2022 Mar 3;23(5):2781. doi: 10.3390/ijms23052781.
AkgĂźn E, Lunzer MM, Tian D, Ansonoff M, Pintar J, Bruce D, Hawkinson JE, Wilcox GL, Portoghese PS., FBNTI, a DOR-Selective Antagonist That Allosterically Activates MOR within a MOR-DOR Heteromer, Biochemistry. 2020 Sep 20. doi: 10.1021/acs.biochem.0c00498. Online ahead of print.
Li, M., Holmes, V., Zhou, Y., Ni, H., Sanzari, J. K., Kennedy, A. R., & Weissman, D. (2014)., Hindlimb suspension and SPE-like radiation impairs clearance of bacterial infections., PloS One, 9(1), e85665. doi:10.1371/journal.pone.0085665 [doi]
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Izzo, A. A., Capasso, R., Aviello, G., Borrelli, F., Romano, B., Piscitelli, F., . . . Di Marzo, V. (2012)., Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from cannabis sativa, on inflammation-induced hypermotility in mice., British Journal of Pharmacology, 166(4), 1444-1460. doi:10.1111/j.1476-5381.2012.01879.x [doi]
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Zhou, Y., Ni, H., Balint, K., Sanzari, J. K., Dentchev, T., Diffenderfer, E. S., . . . Weissman, D. (2014)., Ionizing radiation selectively reduces skin regulatory T cells and alters immune function., PloS One, 9(6), e100800. doi:10.1371/journal.pone.0100800 [doi]
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Zhou, X., Wang, J., Wu, J., Yang, X., Yung, B. C., Lee, L. J., & Lee, R. J. (2014), Preparation and evaluation of a novel liposomal formulation of cisplatin., European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, 66C, 90-95. doi:S0928-0987(14)00386-8 [pii]
Shakhov, A. N., Singh, V. K., Bone, F., Cheney, A., Kononov, Y., Krasnov, P., . . . Feinstein, E. (2012)., Prevention and mitigation of acute radiation syndrome in mice by synthetic lipopeptide agonists of toll-like receptor 2 (TLR2)., PloS One, 7(3), e33044. doi:10.1371/journal.pone.0033044 [doi]
Tiboni, G. M., & Ponzano, A. (2015)., Prevention of valproic acid-induced neural tube defects by sildenafil citrate, Reproductive Toxicology (Elmsford, N.Y.), 56, 175-179. doi:10.1016/j.reprotox.2015.03.004 [doi]
Mao, Y., Wang, J., Zhao, Y., Yan, R., Li, H., Chen, C. S., . . . Phelps, M. A. (2014), Quantification of OSU-2S, a novel derivative of FTY720, in mouse plasma by liquid chromatography-tandem mass spectrometry., Journal of Pharmaceutical and Biomedical Analysis, 98, 160-165. doi:10.1016/j.jpba.2014.05.022 [doi]
Copp, R. R., Peebles, D. D., Soref, C. M., & Fahl, W. E. (2013), Radioprotective efficacy and toxicity of a new family of aminothiol analogs, International Journal of Radiation Biology, 89(7), 485-492. doi:10.3109/09553002.2013.770579 [doi]
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Gardner A, Tepp WH, Bradshaw M, Barbieri JT, Pellett S., Resolution of Two Steps in Botulinum Neurotoxin Serotype A1 Light Chain Localization to the Intracellular Plasma Membrane, Int J Mol Sci. 2021 Oct 15;22(20):11115. doi: 10.3390/ijms222011115.
Yang HS, Kim KM, Boonpraman N, Yoon SM, Seo JE, Park MW, Moon JS, Yoo SY, Yi SS., Respiratory Safety Evaluation in Mice and Inhibition of Adenoviral Amplification in Human Bronchial Endothelial Cells Using a Novel Type of Chlorine Dioxide Gas Reactor, Toxics. 2022 Jan 13;10(1):38. doi: 10.3390/toxics10010038.
Sekonyela, R., Palmer, J. M., Bok, J. W., Jain, S., Berthier, E., Forseth, R., . . . Keller, N. P. (2013), RsmA regulates aspergillus fumigatus gliotoxin cluster metabolites including cyclo(L-phe-L-ser), a potential new diagnostic marker for invasive aspergillosis., PloS One, 8(5), e62591. doi:10.1371/journal.pone.0062591 [doi]
Belcher, L. A., MacKenzie, S. A., Donner, M., Sykes, G. P., Frame, S. R., & Gillies, P. J. (2011)., Safety assessment of EPA-rich triglyceride oil produced from yeast: Genotoxicity and 28-day oral toxicity in rats., Regulatory Toxicology and Pharmacology : RTP, 59(1), 53-63. doi:10.1016/j.yrtph.2010.09.007 [doi]
Barr JT, Tran TB, Rock BM, Wahlstrom JL, Dahal UP., Strain-Dependent Variability of Early Discovery Small Molecule Pharmacokinetics in Mice: Does Strain Matter?, Drug Metab Dispos. 2020 Aug;48(8):613-621. doi: 10.1124/dmd.120.090621. Epub 2020 May 30.
Kendziorski, J. A., & Belcher, S. M. (2015)., Strain-specific induction of endometrial periglandular fibrosis in mice exposed during adulthood to the endocrine disrupting chemical bisphenol A, Reproductive Toxicology (Elmsford, N.Y.), 58, 119-130. doi:10.1016/j.reprotox.2015.08.001 [doi]
Wiley, J. L., Marusich, J. A., Zhang, Y., Fulp, A., Maitra, R., Thomas, B. F., & Mahadevan, A. (2012)., Structural analogs of pyrazole and sulfonamide cannabinoids: Effects on acute food intake in mice, European Journal of Pharmacology, 695(1-3), 62-70. doi:10.1016/j.ejphar.2012.08.019 [doi]
Tebben J, Zurhelle C, Tubaro A, Samdal IA, Krock B, Kilcoyne J, Sosa S, Trainer VL, Deeds JR, Tillmann U., Structure and toxicity of AZA-59, an azaspiracid shellfish poisoning toxin produced by Azadinium poporum (Dinophyceae)., Harmful Algae. 2023 May;124:102388. doi: 10.1016/j.hal.2023.102388. Epub 2023 Jan 22.
AlSharari, S. D., Carroll, F. I., McIntosh, J. M., & Damaj, M. I. (2012)., The antinociceptive effects of nicotinic partial agonists varenicline and sazetidine-A in murine acute and tonic pain models., The Journal of Pharmacology and Experimental Therapeutics, 342(3), 742-749. doi:10.1124/jpet.112.194506 [doi]
Chen, Z., He, Y., & Wang, Z. J. (2012), The beta-lactam antibiotic, ceftriaxone, inhibits the development of opioid-induced hyperalgesia in mice., Neuroscience Letters, 509(2), 69-71. doi:10.1016/j.neulet.2011.12.029 [doi]
Kinsey, S. G., Mahadevan, A., Zhao, B., Sun, H., Naidu, P. S., Razdan, R. K., . . . Lichtman, A. H. (2011)., The CB2 cannabinoid receptor-selective agonist O-3223 reduces pain and inflammation without apparent cannabinoid behavioral effects., Neuropharmacology, 60(2-3), 244-251. doi:10.1016/j.neuropharm.2010.09.004 [doi]
Kierstead, P. H., Okochi, H., Venditto, V. J., Chuong, T. C., Kivimae, S., Frechet, J. M. J., & Szoka, F. C. (2015)., The effect of polymer backbone chemistry on the induction of the accelerated blood clearance in polymer modified liposomes., Journal of Controlled Release : Official Journal of the Controlled Release Society, 213, 1-9. doi:S0168-3659(15)00630-6 [pii]
Brock, W. J., & Bell, T. A. (2012)., The in vitro and in vivo genotoxicity of benzocaine: A brief communication., International Journal of Toxicology, 31(3), 222-227. doi:10.1177/1091581812442230 [doi]
Boitano, S., Hoffman, J., Flynn, A. N., Asiedu, M. N., Tillu, D. V., Zhang, Z., . . . Price, T. J. (2015)., The novel PAR2 ligand C391 blocks multiple PAR2 signalling pathways in vitro and in vivo, British Journal of Pharmacology, doi:10.1111/bph.13238 [doi]
Hadad, N., & Levy, R. (2012)., The synergistic anti-inflammatory effects of lycopene, lutein, beta-carotene, and carnosic acid combinations via redox-based inhibition of NF-kappaB signaling., Free Radical Biology & Medicine, 53(7), 1381-1391. doi:10.1016/j.freeradbiomed.2012.07.078 [doi]
Wang M, Yang X, Pan Z, Wang Y, De La Cruz LK, Wang B, Tan C., Towards "CO in a pill": Pharmacokinetic studies of carbon monoxide prodrugs in mice, J Control Release. 2020 Nov 10;327:174-185. doi: 10.1016/j.jconrel.2020.07.040. Epub 2020 Aug 1.
D'Amico R, Gugliandolo E, Siracusa R, Cordaro M, Genovese T, Peritore AF, Crupi R, Interdonato L, Di Paola D, Cuzzocrea S, Fusco R, Impellizzeri D, Di Paola R., Toxic Exposure to Endocrine Disruptors Worsens Parkinson's Disease Progression through NRF2/HO-1 Alteration, Biomedicines. 2022 May 5;10(5):1073. doi: 10.3390/biomedicines10051073.
Protti-Sánchez, Francesca; Quirós-Guerrero, Luis; Vásquez, Víctor; Willink, Beatriz; Pacheco, Mariano; León, Edwin; Pröhl, Heike; Bolaños, Federico;, Toxicity and Alkaloid Profiling of the Skin of the Golfo Dulcean Poison Frog Phyllobates vittatus (Dendrobatidae)., Journal of chemical ecology Vol.45, 2019
Yang LY, Gao JL, Gao T, Dong P, Ma L, Jiang FL, Liu Y., Toxicity of polyhydroxylated fullerene to mitochondria, J Hazard Mater. 2016 Jan 15;301:119-26. doi: 10.1016/j.jhazmat.2015.08.046. Epub 2015 Aug 28.
Tait, S., Tassinari, R., Maranghi, F., & Mantovani, A. (2015)., Toxicogenomic analysis of placenta samples from mice exposed to different doses of BPA., Genomics Data, 4, 109-111. doi:10.1016/j.gdata.2015.04.004 [doi]
Yigit S, Hallaj NS, Sugarman JL, Chong LC, Roman SE, Abu-Taleb LM, Goodman RE, Johnson PE, Behrens AM., Toxicological assessment and food allergy of silk fibroin derived from Bombyx mori cocoons, Food Chem Toxicol. 2021 May;151:112117. doi: 10.1016/j.fct.2021.112117. Epub 2021 Mar 17.
Anand, S. S., Serex, T. L., Carpenter, C., Donner, E. M., Hoke, R., Buck, R. C., & Loveless, S. E. (2012)., Toxicological assessment of tridecafluorohexylethyl methacrylate (6:2 FTMAC)., Toxicology, 292(1), 42-52. doi:10.1016/j.tox.2011.11.016 [doi]
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Pascuali N, Pu Y, Waye AA, Pearl S, Martin D, Sutton A, Shikanov A, Veiga-Lopez A., Evaluation of Lipids and Lipid-Related Transcripts in Human and Ovine Theca Cells and an in Vitro Mouse Model Exposed to the Obesogen Chemical Tributyltin., Environ Health Perspect. 2024 Apr;132(4):47009. doi: 10.1289/EHP13955. Epub 2024 Apr 17.

Vaccines

Bhaskar, V., Goldfine, I. D., Bedinger, D. H., Lau, A., Kuan, H. F., Gross, L. M., . . . Corbin, J. A. (2012), A fully human, allosteric monoclonal antibody that activates the insulin receptor and improves glycemic control., Diabetes, 61(5), 1263-1271. doi:10.2337/db11-1578 [doi]
Sia ZR, He X, Zhang A, Ang JC, Shao S, Seffouh A, Huang WC, D'Agostino MR, Teimouri Dereshgi A, Suryaprakash S, Ortega J, Andersen H, Miller MS, Davidson BA, Lovell JF., A liposome-displayed hemagglutinin vaccine platform protects mice and ferrets from heterologous influenza virus challenge, Proc Natl Acad Sci U S A. 2021 Jun 1;118(22):e2025759118. doi: 10.1073/pnas.2025759118.
Seitz, M., Beineke, A., Seele, J., Fulde, M., Valentin-Weigand, P., & Baums, C. G. (2012), A novel intranasal mouse model for mucosal colonization by streptococcus suis serotype 2., Journal of Medical Microbiology, 61(Pt 9), 1311-1318. doi:10.1099/jmm.0.043885-0 [doi]
Jedličková, Lucie; Dvořák, Jan; Hrachovinová, Ingrid; Ulrychová, Lenka; Kašný , Martin; Mikeš, Libor;, A novel Kunitz protein with proposed dual function from Eudiplozoon nipponicum (Monogenea) impairs haemostasis and action of complement in vitro, International journal for parasitology Vol.49, 2019
He X, Zhou S, Huang WC, Seffouh A, Mabrouk MT, Morgan MT, Ortega J, Abrams SI, Lovell JF., A Potent Cancer Vaccine Adjuvant System for Particleization of Short, Synthetic CD8(+) T Cell Epitopes, ACS Nano. 2021 Mar 23;15(3):4357-4371. doi: 10.1021/acsnano.0c07680. Epub 2021 Feb 19.
Li, Yong; Duah, Ernest; Long, Nick; Persaud, Avinash; VanGundy, Zachary; Magliery, Thomas; Poi, Ming J;, An efficient and quantitative assay for epitope-tagged therapeutic protein development with a capillary western system., Bioanalysis Vol.11, 2019
Park, S., Gerber, S., & Lee, J. C. (2014), Antibodies to staphylococcus aureus serotype 8 capsular polysaccharide react with and protect against serotype 5 and 8 isolates., Infection and Immunity, 82(12), 5049-5055. doi:10.1128/IAI.02373-14 [doi]
Huang WC, Deng B, Seffouh A, Ortega J, Long CA, Suresh RV, He X, Miura K, Lee SM, Wu Y, Lovell JF., Antibody response of a particle-inducing, liposome vaccine adjuvant admixed with a Pfs230 fragment, NPJ Vaccines. 2020 Mar 18;5:23. doi: 10.1038/s41541-020-0173-x. eCollection 2020.
Pflepsen KR, Peterson CD, Kitto KF, Riedl MS, McIvor RS, Wilcox GL, Vulchanova L, Fairbanks CA., Biodistribution of Adeno-Associated Virus Serotype 5 Viral Vectors Following Intrathecal Injection, Mol Pharm. 2021 Oct 4;18(10):3741-3749. doi: 10.1021/acs.molpharmaceut.1c00252. Epub 2021 Aug 30.
Marshall, S., Hujer, A. M., Rojas, L. J., Papp-Wallace, K. M., Humphries, R. M., Spellberg, B., . . . Bonomo, R. A. (2017)., Can ceftazidime-avibactam and aztreonam overcome beta-lactam resistance conferred by metallo-beta-lactamases in enterobacteriaceae?, Antimicrobial Agents and Chemotherapy, 61(4), 10.1128/AAC.02243-16. Print 2017 Apr. doi:e02243-16 [pii]
Rangel G, Bárcena J, Moreno N, Mata CP, Castón JR, Alejo A, Blanco E., Chimeric RHDV Virus-Like Particles Displaying Foot-and-Mouth Disease Virus Epitopes Elicit Neutralizing Antibodies and Confer Partial Protection in Pigs, Vaccines (Basel). 2021 May 7;9(5):470. doi: 10.3390/vaccines9050470.
Velineni, S., Timoney, J. F., Russell, K., Hamlen, H. J., Pesavento, P., Fortney, W. D., & Crawford, P. C. (2014)., Clones of streptococcus zooepidemicus from outbreaks of hemorrhagic canine pneumonia and associated immune responses., Clinical and Vaccine Immunology : CVI, 21(9), 1246-1252. doi:10.1128/CVI.00222-14 [doi]
Vaickus, L. J., Bouchard, J., Kim, J., Natarajan, S., & Remick, D. G. (2012)., Cockroach allergens induce biphasic asthma-like pulmonary inflammation in outbred mice., The Journal of Asthma : Official Journal of the Association for the Care of Asthma, 49(5), 510-521. doi:10.3109/02770903.2012.678958 [doi]
Walton, K. D., Lord, A., Kendall, L. V., & Dow, S. W. (2014)., Comparison of 3 real-time, quantitative murine models of staphylococcal biofilm infection by using in vivo bioluminescent imaging., Comparative Medicine, 64(1), 25-33.
Henderson, A. J., Kumar, A., Barnett, B., Dow, S. W., & Ryan, E. P. (2012)., Consumption of rice bran increases mucosal immunoglobulin A concentrations and numbers of intestinal lactobacillus spp, Journal of Medicinal Food, 15(5), 469-475. doi:10.1089/jmf.2011.0213 [doi]
Burnley, B., & P Jones, H. (2017)., Corticotropin-releasing hormone improves survival in pneumococcal pneumonia by reducing pulmonary inflammation, Physiological Reports, 5(1), 10.14814/phy2.13000. doi:e13000 [pii]
Borrego, B., Rodriguez-Pulido, M., Mateos, F., de la Losa, N., Sobrino, F., & Saiz, M. (2013)., Delivery of synthetic RNA can enhance the immunogenicity of vaccines against foot-and-mouth disease virus (FMDV) in mice, Vaccine, 31(40), 4375-4381. doi:10.1016/j.vaccine.2013.07.008 [doi]
Beinborn, N. A., Du, J., Wiederhold, N. P., Smyth, H. D., & Williams, R. O.,3rd. (2012)., Dry powder insufflation of crystalline and amorphous voriconazole formulations produced by thin film freezing to mice., European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik e.V, 81(3), 600-608. doi:10.1016/j.ejpb.2012.04.019 [doi]
Boilesen DR, Neckermann P, Willert T, Müller MD, Schrödel S, Pertl C, Thirion C, Asbach B, Wagner R, Holst PJ., Efficacy and synergy with cisplatin of an adenovirus vectored therapeutic E1E2E6E7 vaccine against HPV genome positive C3 cancers in mice, Cancer Immunol Res. 2022 Dec 19:CIR-22-0174. doi: 10.1158/2326-6066.CIR-22-0174. Online ahead of print.
Boilesen DR, Neckermann P, Willert T, Müller MD, Schrödel S, Pertl C, Thirion C, Asbach B, Wagner R, Holst PJ., Efficacy and Synergy with Cisplatin of an Adenovirus Vectored Therapeutic E1E2E6E7 Vaccine against HPV Genome-Positive C3 Cancers in Mice., Cancer Immunol Res. 2023 Feb 3;11(2):261-275. doi: 10.1158/2326-6066.CIR-22-0174.
Bauza, K., Malinauskas, T., Pfander, C., Anar, B., Jones, E. Y., Billker, O., . . . Reyes-Sandoval, A. (2014)., Efficacy of a plasmodium vivax malaria vaccine using ChAd63 and modified vaccinia ankara expressing thrombospondin-related anonymous protein as assessed with transgenic plasmodium berghei parasites., Infection and Immunity, 82(3), 1277-1286. doi:10.1128/IAI.01187-13 [doi]
Spencer, A. J., Cottingham, M. G., Jenks, J. A., Longley, R. J., Capone, S., Colloca, S., . . . Hill, A. V. (2014)., Enhanced vaccine-induced CD8+ T cell responses to malaria antigen ME-TRAP by fusion to MHC class ii invariant chain, PloS One, 9(6), e100538. doi:10.1371/journal.pone.0100538 [doi]
Huang, C. T., Li, Z., Huang, Y., Zhang, G., Zhou, M., Chai, Q., . . . Fu, Z. F. (2014)., Enhancement of blood-brain barrier permeability is required for intravenously administered virus neutralizing antibodies to clear an established rabies virus infection from the brain and prevent the development of rabies in mice, Antiviral Research, 110, 132-141. doi:10.1016/j.antiviral.2014.07.013 [doi]
Kamali, A. N., Marin-Garcia, P., Azcarate, I. G., Puyet, A., Diez, A., & Bautista, J. M. (2015)., Experimental immunization based on plasmodium antigens isolated by antibody affinity., Journal of Immunology Research, 2015, 723946. doi:10.1155/2015/723946 [doi]
Spencer AJ, McKay PF, Belij-Rammerstorfer S, Ulaszewska M, Bissett CD, Hu K, Samnuan K, Blakney AK, Wright D, Sharpe HR, Gilbride C, Truby A, Allen ER, Gilbert SC, Shattock RJ, Lambe T., Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice, Nat Commun. 2021 May 17;12(1):2893. doi: 10.1038/s41467-021-23173-1.
Heneghan, A. F., Pierre, J. F., & Kudsk, K. A. (2013), IL-25 improves IgA levels during parenteral nutrition through the JAK-STAT pathway., Annals of Surgery, 258(6), 1065-1071. doi:10.1097/SLA.0b013e318277ea9e [doi]
Cańas-Arranz R, de León P, Defaus S, Torres E, Forner M, Bustos MJ, Andreu D, Blanco E, Sobrino F., Immunogenicity of Foot-and-Mouth Disease Virus Dendrimer Peptides: Need for a T-Cell Epitope and Ability to Elicit Heterotypic Responses, Molecules. 2021 Aug 4;26(16):4714. doi: 10.3390/molecules26164714.
Federizon, Jasmin; Frye, Amber; Huang, Wei-Chiao; Hart, Thomas M; He, Xuedan; Beltran, Christopher; Marcinkiewicz, Ashley L; Mainprize, Iain L; Wills, Melanie K B; Lin, Yi-Pin; Lovell, Jonathan F;, Immunogenicity of the Lyme disease antigen OspA, particleized by cobalt porphyrin-phospholipid liposomes., Vaccine Vol.38, 2020
Hernandez-Haro, C., Llopis, S., Molina, M., Monteoliva, L., & Gil, C. (2015)., Immunoproteomic profiling of saccharomyces cerevisiae systemic infection in a murine model., Journal of Proteomics, 112, 14-26. doi:10.1016/j.jprot.2014.08.008 [doi]
Richard, G., Meyers, A. J., McLean, M. D., Arbabi-Ghahroudi, M., MacKenzie, R., & Hall, J. C. (2013)., In vivo neutralization of alpha-cobratoxin with high-affinity llama single-domain antibodies (VHHs) and a VHH-fc antibody., PloS One, 8(7), e69495. doi:10.1371/journal.pone.0069495 [doi]
Monso, M., de la Torre, B. G., Blanco, E., Moreno, N., & Andreu, D. (2013), Influence of conjugation chemistry and B epitope orientation on the immune response of branched peptide antigens., Bioconjugate Chemistry, 24(4), 578-585. doi:10.1021/bc300515t [doi]
Ryu, S., Park, Y., Kim, B., Cho, S. M., Lee, J., Lee, H. H., . . . Song, P. I. (2014)., Inhibitory and anti-inflammatory effects of the helicobacter pylori-derived antimicrobial peptide HPA3NT3 against propionibacterium acnes in the skin., The British Journal of Dermatology, 171(6), 1358-1367. doi:10.1111/bjd.13480 [doi]
Ghedin, E., Rogers, M. B., Widen, S. G., Guzman, H., Travassos da Rosa, A. P., Wood, T. G., . . . Tesh, R. B. (2013)., Kolente virus, a rhabdovirus species isolated from ticks and bats in the republic of guinea., The Journal of General Virology, 94(Pt 12), 2609-2615. doi:10.1099/vir.0.055939-0 [doi]
Jiménez de Oya N, Pérez P, Blázquez AB, Escribano-Romero E, Esteban M, Saiz JC, García-Arriaza J, Martín-Acebes MA., Low Immune Cross-Reactivity between West Nile Virus and a Zika Virus Vaccine Based on Modified Vaccinia Virus Ankara, Pharmaceuticals (Basel). 2022 Mar 15;15(3):354. doi: 10.3390/ph15030354.
Dallas, A., Ilves, H., Shorenstein, J., Judge, A., Spitler, R., Contag, C., . . . Johnston, B. H. (2013), Minimal-length synthetic shRNAs formulated with lipid nanoparticles are potent inhibitors of hepatitis C virus IRES-linked gene expression in mice, Molecular Therapy.Nucleic Acids, 2, e123. doi:10.1038/mtna.2013.50 [doi]
Thornton, M. M., Chung-Esaki, H. M., Irvin, C. B., Bortz, D. M., Solomon, M. J., & Younger, J. G. (2012)., Multicellularity and antibiotic resistance in klebsiella pneumoniae grown under bloodstream-mimicking fluid dynamic conditions., The Journal of Infectious Diseases, 206(4), 588-595. doi:10.1093/infdis/jis397 [doi]
Sei, Clara J; Shey, Bong-Akee; Schuman, Richard F; Rikhi, Nimisha; Muema, Kevin; Rodriguez, John D; Daum, Luke T; Fourie, P Bernard; Fischer, Gerald W;, Opsonic monoclonal antibodies enhance phagocytic killing activity and clearance of Mycobacterium tuberculosis from blood in a quantitative qPCR mouse model., Heliyon Vol.5, 2019
Mitchell, L. A., Hansen, R. J., Beaupre, A. J., Gustafson, D. L., & Dow, S. W. (2013)., Optimized dosing of a CCR2 antagonist for amplification of vaccine immunity., International Immunopharmacology, 15(2), 357-363. doi:10.1016/j.intimp.2012.11.016 [doi]
Morro, M., Teichenne, J., Jimenez, V., Kratzer, R., Marletta, S., Maggioni, L., . . . Ayuso, E. (2014)., Pancreatic transduction by helper-dependent adenoviral vectors via intraductal delivery., Human Gene Therapy, 25(9), 824-836. doi:10.1089/hum.2013.182 [doi]
Lepak, Alexander J; Zhao, Miao; Liu, Qingmei; Wang, Ping; Wang, Yanli; Bader, Justin C; Ambrose, Paul G; Andes, David R, Pharmacokinetic/Pharmacodynamic Ealuation of a Novel Aminomethylcycline Antibiotic, KBP-7072, in the Neutropenic Murine Pneumonia Model against Staphylococcus aureus and Streptococcus pneumoniae, Antimicrobial agents and chemotherapy Vol.63, 2019
Lepak, Alexander J; Zhao, Miao; Liu, Qingmei; Wang, Ping; Wang, Yanli; Bader, Justin C; Ambrose, Paul G; Andes, David R, Pharmacokinetic/Pharmacodynamic Evaluation of a Novel Aminomethylcycline Antibiotic, KBP-7072, in the Neutropenic Murine Pneumonia Model against Staphylococcus aureus and Streptococcus pneumoniae, Antimicrobial agents and chemotherapy Vol.63, 2019
Kamali, A. N., Marin-Garcia, P., Azcarate, I. G., Diez, A., Puyet, A., & Bautista, J. M. (2012)., Plasmodium yoelii blood-stage antigens newly identified by immunoaffinity using purified IgG antibodies from malaria-resistant mice., Immunobiology, 217(8), 823-830. doi:10.1016/j.imbio.2012.05.002 [doi]
Zhang, G., Wang, H., Mahmood, F., & Fu, Z. F. (2013)., Rabies virus glycoprotein is an important determinant for the induction of innate immune responses and the pathogenic mechanisms., Veterinary Microbiology, 162(2-4), 601-613. doi:10.1016/j.vetmic.2012.11.031 [doi]
Zhou, M., Zhang, G., Ren, G., Gnanadurai, C. W., Li, Z., Chai, Q., . . . Fu, Z. F. (2013), Recombinant rabies viruses expressing GM-CSF or flagellin are effective vaccines for both intramuscular and oral immunizations., PloS One, 8(5), e63384. doi:10.1371/journal.pone.0063384 [doi]
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Wang, Y., Kuo, S., Shu, M., Yu, J., Huang, S., Dai, A., . . . Huang, C. M. (2014), Staphylococcus epidermidis in the human skin microbiome mediates fermentation to inhibit the growth of propionibacterium acnes: Implications of probiotics in acne vulgaris., Applied Microbiology and Biotechnology, 98(1), 411-424. doi:10.1007/s00253-013-5394-8 [doi]
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