Cox1 knockout rats
HsdSage:SD-Cox1em1Sage
Strain
Location
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Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
- Homozygous knockout rats exhibit complete loss of COX1 protein via Western blot
- Background Strain: Sprague-Dawley
Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous
Cyclooxygenase (COX), also known as prostaglandin synthase (PHS) and prostaglandin endoperoxide synthetase (PES), is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. Rats deficient in COX1 can be used for studying inflammation, thrombosis, vascular defects, platelet defects and alterations in platelet aggregation.
Origin:
The Cox1 Knockout Rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.
Available regions:
For pricing information, please contact us using the phone number above.
Research use and related publications
- Asthma
- Colitis
- Crohn's disease
- Immunology
- Multiple sclerosis
- Platelet defects/Platelet aggregation
- Renal dysplasia
- Rheumatoid arthritis
- Inflammation/Autoimmune disorders
- Thrombosis/Cardiac fibrosis
- Vascular defects
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