SORD Knockout Rat

NTac:SD-Sord^em1Env

Strain

NTac:SD-Sord^em1Env

Location

U.S. (Cryopreserved)

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Description

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Cryopreserved

Background strain: Sprague Dawley

Availability: Cryopreserved
Zygosity genotype: Heterozygote embryos

Developed in collaboration with the Hereditary Neuropathy Foundation, this model contains an 18 kb deletion encompassing the coding regions of rat Sord, leading to a total loss of expression of the enzyme, sorbital dehydrogenase. Loss of expression of the Sord gene can result in Sorbitol Dehydorgenase Deficiency and is associated with the autosomal recessive form of CMT2 and distal hereditary motor neuropathy (dHMN).

This model was generated for the Hereditary Neuropathy foundation and underwent phenotypic characterization by Dr. Zuchner at University of Miami.

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