CFTR knockout rats
HsdSage:SD-Cftrem1Sage
Strain
Location
Order Today
Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
- Homozygotes exhibit multiple phenotypes involving intestinal, respiratory, and reproductive phenotypes (see Description).
Availability: Cryopreserved as a mix of Heterozygous & WT embryos
Zygosity: Heterozygous as live colony
CFTR knockout rats possess a 16 bp deletion in exon 3 of the Cystic Fibrosis transmembrane conductance regulator (CFTR), resulting in loss of protein expression.
CFTR knockout rats lack CFTR protein as demonstrated by western blot. CFTR KO rats develop intestinal obstructions shortly after weaning leading to weight loss and mortality. CFTR KO rats also exhibit decreased trachea circumference as well as submucosal gland volume. Stored nasal mucus volume is increased. Abnormal dentition is observed, and the vas deferens is absent in male CFTR knockout rats.
Origin: The CFTR KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.
Available regions:
For pricing information, please contact us using the phone number above.
Research use and related publications
- Lung Disease
- Chloride transport
- Cystic Fibrosis
- Lung Disease
- Thiocyanide transport
2025 Product guide
Receive a copy of our current research models and services product guide.
SCIENTIFIC
INSIGHTS
Keep up-to-date with the latest industry thinking and scientific insights
Explore today
More than 90 years of working together, to build a healthier and safer world
Explore our history
Subscribe to updates from Inotiv
Sign up and you’ll receive the latest updates that matter to you, delivered straight to your inbox.
