B-NDG hIL15 mice

• Background strain: NOD.SCID

Availability: Live colony (limited)

Zygosity genotype: Homozygous

The B-NDG hIL15 model is a single knockout mouse with an ultra-immunodeficient phenotype. The model was generated by Biocytogen by deleting the IL2rg gene from NOD-scid mice. Prkdc (protein kinase DNA-activated catalytic) null scid mutation is characterized by significantly deficient of functional T cells and B cells.

The Common gamma chain gene (IL2RG) deletion results in a lack of functional receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21, which results in the lack of functional NK cells.

The human IL15 gene was inserted after the 5′UTR of the mouse IL15, so that this mouse expresses the human IL15 cytokine. This mouse combines a B-NDG mouse background and expresses human IL15 cytokine. It will become a suitable animal model to investigate development and function of human NK cells.

Origin:

The model was developed by Biocytogen. Envigo licensed the mouse model from Biocytogen in 2021, where the model had been maintained. The model is maintained and distributed by Envigo, acquired by Inotiv in 2021.

Diet and Husbandry:
Our rodent models are raised and maintained on Teklad diet, bedding, and enrichment products:

• Diet: Teklad Global Rodent Diet
• Bedding: Teklad Contact Bedding (U.S. only)
• Enrichment: Teklad Enrichment Products (U.S. only)

Model Support Services:
Inotiv offers related model support services to deliver research-ready models to your facility:

• Surgical Services
• Preconditioning Services
• Aging Services
• Contract Breeding Services
• Biospecimen Services

• The Netherlands - B3 ISO B-NDG hIL15

Available regions:

II. Non-Profit (Academic) Male Order code: 406 - DE

II. Non-Profit (Academic) Female Order code: 406 - DE

I. For-Profit (Commercial) Male Order code: 406 - DE

I. For-Profit (Commercial) Female Order code: 406 - DE

• Model information sheet
• Development, Characterization, and Validation of B-NDG hIL15 Mice white paper