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Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
- Homozygous knockout rats exhibit complete loss of protein
- Background Strain: Sprague-Dawley
Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous as live colony
This model carries a bi-allelic deletion of the amyloid precursor protein (APP) gene. APP can be cleaved by the beta and gamma secretases, forming beta amyloid. Beta amyloid can self-aggregate to form amyloid plaques, one of the hallmarks of Alzheimer's disease.
Origin:
The App Knockout Rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.
Available regions:
For pricing information, please contact us using the phone number above.
Research use and related publications
- Alzheimer's disease
- Dementia
- Memory loss
- Neurodegeneration
- Neuroscience
- Synaptic formation and repair
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