Unveiling the Rodent Model Powerhouse: Why Sprague Dawley^® Rats are Essential for Medical Research

sprague-dawley Sprague Dawley^® rats are crucial for scientific research, being one of the most extensively studied domesticated rodent strains. These rats, easily bred in captivity, possess a wide range of genetic variability that results in large litters suitable for laboratory research. For decades, scientists have investigated the behavior and physiology of these rats, providing invaluable insights into human health. Discover why Sprague Dawley rats have gained popularity as a laboratory animal among scientists worldwide.

Sprague Dawley rats are a widely utilized rat model in biomedical research, offering scientists a valuable tool to investigate various medical and scientific inquiries. Originally developed in the early 20th century by genetics researcher Robert Dawley and physiologist Charles Sprague, this breed was created by crossing a Wistar albino rat with a hybrid hooded rat. The result is an outbred population of Sprague Dawley rats that is genetically diverse, providing a broad representation of genetic variation within the species. Known for their docile and friendly nature, Sprague Dawley rats are easy to work with in the laboratory. Additionally, their larger size makes them well-suited for surgeries and other experimental procedures. These characteristics have made Sprague Dawley rats a staple in research across various fields, serving as a crucial resource for scientists worldwide.

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Hsd:Sprague Dawley^® SD^®

Benefits of Using Sprague Dawley Rats in Research

When conducting research, selecting the right animal model is crucial. Sprague Dawley rats have been a popular choice for researchers due to their genetic diversity and ease of handling. These rats also exhibit numerous physiological and behavioral characteristics that resemble those of humans, making them an ideal animal model for a wide range of studies. Furthermore, the use of outbred rats in research reduces the risk of biased data and increases the replicability of results. By utilizing Sprague Dawley rats, researchers can gain more accurate insights into complex biological systems and diseases and can lead to more effective treatments and therapies for humans.

Important Characteristics of Sprague Dawley Rats

Sprague Dawley rats are a popular animal model for biomedical research due to their well-established phenotype and genetic variability. These rats are known for their calm and docile demeanor, which makes them easier to work with. In addition, they have a long lifespan and reach sexual maturity at an early age, allowing for multiple generations of research. Another important characteristic of these rats is their immunological and physiological similarity to humans, making them ideal for studying various diseases and testing treatments. Researchers can confidently use Sprague Dawley rats as a reliable and effective model for studying a wide range of biomedical topics ethically and humanely.

What Types of Research Are Suitable for Sprague Dawley Rats

When considering the use of Sprague Dawley rats for research, it is important to keep in mind their unique characteristics. These rats are known for their hardiness and adaptability, making them suitable for a variety of experimental designs. However, it is important to consider their size and metabolism when choosing which experiments to conduct. Sprague Dawley rats are particularly well-suited for studies involving toxicology, pharmacology, and general research. Additionally, these rats are widely used in the fields of neuroscience, metabolism, and cardiology to study chronic diseases such as diabetes and hypertension. With careful consideration of their unique features, Sprague Dawley rats can be an excellent choice for a wide range of experimental designs.

Potential Challenges When Working with Sprague Dawley Rats

Working with Sprague Dawley rats can present unique challenges for researchers and laboratory technicians. Because these rats are outbred, meaning they have diverse genetic backgrounds, their behavior and response to experiments can be more variable than in inbred strains. Additionally, these rats are known to be larger and more active than other strains, which can require specialized equipment, enrichment, and handling techniques. It is important for those working with Sprague Dawley rats to thoroughly understand their traits and behavior to accurately interpret study results and ensure their safety and a high standard of animal welfare. With proper planning and training, however, these potential challenges can be navigated by knowledgeable professionals.

Characteristics

Coat: Albino
Docile disposition
Excellent reproductive performance and maternal characteristics
Litter Average: 11.0
Most widely-used outbred rat in animal research

Sprague Dawley^® outbred rats publications

ADMET

Pohjanvirta R, Mahiout S., Aryl hydrocarbon receptor is indispensable for β-naphthoflavone-induced novel food avoidance and may be involved in LiCl-triggered conditioned taste aversion in rats., Physiol Behav. 2019 May 15;204:58-64.

Harrill JA, Layko D, Nyska A, Hukkanen RR, Manno RA, Grassetti A, Lawson M, Martin G, Budinsky RA, Rowlands JC, Thomas RS., Aryl hydrocarbon receptor knockout rats are insensitive to the pathological effects of repeated oral exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin., J Appl Toxicol. 2016 Jun;36(6):802-14.

Phadnis-Moghe AS, Chen W, Li J, Crawford RB, Bach A, D'Ingillo S, Kovalova N, Suarez-Martinez JE, Kaplan BL, Harrill JA, Budinsky R, Rowlands JC, Thomas RS, Kaminski NE., Immunological characterization of the aryl hydrocarbon receptor (AHR) knockout rat in the presence and absence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)., Toxicology. 2016 Aug 10;368-369:172-182.

Harrill JA, Hukkanen RR, Lawson M, Martin G, Gilger B, Soldatow V, Lecluyse EL, Budinsky RA, Rowlands JC, Thomas RS., Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18

Aging

Bolles, M., Deming, D., Long, K., Agnihothram, S., Whitmore, A., Ferris, M., . . . Baric, R. S. (2011)., A double-inactivated severe acute respiratory syndrome coronavirus vaccine provides incomplete protection in mice and induces increased eosinophilic proinflammatory pulmonary response upon challenge, Journal of Virology, 85(23), 12201-12215. doi:10.1128/JVI.06048-11 [doi]

Corsetti, G., Pasini, E., Romano, C., Calvani, R., Picca, A., Marzetti, E., . . . Dioguardi, F. S. (2018)., Body weight loss and tissue wasting in late middle-aged mice on slightly imbalanced Essential/Non-essential amino acids diet., Frontiers in Medicine, 5, 136. doi:10.3389/fmed.2018.00136 [doi]

Rockx, B., Baas, T., Zornetzer, G. A., Haagmans, B., Sheahan, T., Frieman, M., . . . Katze, M. G. (2009), Early upregulation of acute respiratory distress syndrome-associated cytokines promotes lethal disease in an aged-mouse model of severe acute respiratory syndrome coronavirus infection, Journal of Virology, 83(14), 7062-7074. doi:10.1128/JVI.00127-09 [doi]

Barone, R., Macaluso, F., Catanese, P., Marino Gammazza, A., Rizzuto, L., Marozzi, P., . . . Di Felice, V. (2013)., Endurance exercise and conjugated linoleic acid (CLA) supplementation up-regulate CYP17A1 and stimulate testosterone biosynthesis, PloS One, 8(11), e79686. doi:10.1371/journal.pone.0079686 [doi]

Clayton, E. H., Garbow, J. R., & Bayly, P. V. (2011)., Frequency-dependent viscoelastic parameters of mouse brain tissue estimated by MR elastography, Physics in Medicine and Biology, 56(8), 2391-2406. doi:10.1088/0031-9155/56/8/005 [doi]

Cayatte, C., Snell Bennett, A., Rajani, G. M., Hostetler, L., Maynard, S. K., Lazzaro, M., . . . Schneider-Ohrum, K. (2017)., Inferior immunogenicity and efficacy of respiratory syncytial virus fusion protein-based subunit vaccine candidates in aged versus young mice., PloS One, 12(11), e0188708. doi:10.1371/journal.pone.0188708 [doi]

Grizenkova, J., Akhtar, S., Brandner, S., Collinge, J., & Lloyd, S. E. (2014), Microglial Cx3cr1 knockout reduces prion disease incubation time in mice., BMC Neuroscience, 15, 44-2202-15-44. doi:10.1186/1471-2202-15-44 [doi]

Antibody production

Rijal P, Wang BB, Tan TK, Schimanski L, Janesch P, Dong T, McCauley JW, Daniels RS, Townsend AR, Huang KA., Broadly Inhibiting Antineuraminidase Monoclonal Antibodies Induced by Trivalent Influenza Vaccine and H7N9 Infection in Humans, J Virol. 2020 Jan 31;94(4):e01182-19. doi: 10.1128/JVI.01182-19. Print 2020 Jan 31.

McKitrick TR, Goth CK, Rosenberg CS, Nakahara H, Heimburg-Molinaro J, McQuillan AM, Falco R, Rivers NJ, Herrin BR, Cooper MD, Cummings RD., Development of smart anti-glycan reagents using immunized lampreys, Commun Biol. 2020 Feb 28;3(1):91. doi: 10.1038/s42003-020-0819-2.

Boyoglu-Barnum S, Hutchinson GB, Boyington JC, Moin SM, Gillespie RA, Tsybovsky Y, Stephens T, Vaile JR, Lederhofer J, Corbett KS, Fisher BE, Yassine HM, Andrews SF, Crank MC, McDermott AB, Mascola JR, Graham BS, Kanekiyo M., Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses, Nat Commun. 2020 Feb 7;11(1):791. doi: 10.1038/s41467-020-14579-4.

Hemon MF, Lambert NC, Arnoux F, Roudier J, Auger I., PAD4 Immunization Triggers Anti-Citrullinated Peptide Antibodies in Normal Mice: Analysis With Peptide Arrays, Front Immunol. 2022 Mar 31;13:840035. doi: 10.3389/fimmu.2022.840035. eCollection 2022.

Atherosclerosis

Sijbesma JWA, van Waarde A, Kristensen S, Kion I, Tietge UJF, Hillebrands JL, Bulthuis MLC, Buikema H, Nakladal D, Westerterp M, Liu F, Boersma HH, Dierckx RAJO, Slart RHJA, Characterization of a novel model for atherosclerosis imaging: the apolipoprotein E-deficient rat, EJNMMI Res. 2023 Dec 11;13(1):106. doi: 10.1186/s13550-023-01055-5.

Berenji Ardestani S, Eftedal I, Pedersen M, Jeppesen PB, Nørregaard R, Matchkov VV., Endothelial dysfunction in small arteries and early signsÂ of atherosclerosis in ApoE knockout rats, Sci Rep. 2020 Sep 17;10(1):15296. doi: 10.1038/s41598-020-72338-3.

Berenji Ardestani S, Matchkov VV, Hansen K, Jespersen NR, Pedersen M, Eftedal I., Extensive Simulated Diving Aggravates Endothelial Dysfunction in Male Pro-atherosclerotic ApoE Knockout Rats, Front Physiol. 2020 Dec 23;11:611208. doi: 10.3389/fphys.2020.611208. eCollection 2020.

Wu, Y.; Johnson, G.; Zhao, F.; Wu, Y.; Zhao, G.; Brown, A.; You, S.; Zou, M.-H.; Song, P., Features of Lipid Metabolism in Humanized ApoE Knockin Rat Models, International Journal of Molecular Sciences. 2021; 22(15):8262.

Yang, J. H., Niu, W., Li, Y., & Azadzoi, K. M., Impairment of AMPK-?2 augments detrusor contractions in bladder ischemia, Investigative and Clinical Urology 62, no. 5 (2021): 600.

Nguyen TD, Watanabe A, Burleigh S, Ghaffarzadegan T, Kanklai J, Prykhodko O, Hållenius FF, Nyman M., Monobutyrin and monovalerin improve gut-blood-brain biomarkers and alter gut microbiota composition in high-fat fed apolipoprotein-E-knockout rats., Psychopharmacology (Berl). 2023 Jan;240(1):137-147. doi: 10.1007/s00213-022-06286-3. Epub 2022 Dec 5.

Nakladal, D., Sijbesma, J. W. A., Visser, L. M., Tietge, U. J. F., Slart, R. H. J. A., Deelman, L. E., ... & Buikema, H., Perivascular adipose tissue-derived nitric oxide compensates endothelial dysfunction in aged pre-atherosclerotic apolipoprotein E-deficient rats, Vascular pharmacology (2021): 106945.

Nakladal D, Sijbesma JWA, Visser LM, Tietge UJF, Slart RHJA, Deelman LE, Henning RH, Hillebrands JL, Buikema H., Perivascular adipose tissue-derived nitric oxide compensates endothelial dysfunction in aged pre-atherosclerotic apolipoprotein E-deficient rats., Vascul Pharmacol. 2022 Feb;142:106945. doi: 10.1016/j.vph.2021.106945. Epub 2021 Nov 18.

Autoimmune disease

Kalliokoski, S., Caja, S., Frias, R., Laurila, K., Koskinen, O., Niemela, O., . . . Lindfors, K. (2015), Injection of celiac disease patient sera or immunoglobulins to mice reproduces a condition mimicking early developing celiac disease., Journal of Molecular Medicine (Berlin, Germany), 93(1), 51-62. doi:10.1007/s00109-014-1204-8 [doi]

Cardiovascular

Wu Y, Zhao F, Sure VN, Ibrahim A, Yu C, Carr SM, Song P., Human ApoE2 Endows Stronger Contractility in Rat Cardiomyocytes Enhancing Heart Function, Cells. 2023 Jan 17;12(3):347. doi: 10.3390/cells12030347.

Corsetti G, Romano C, Pasini E, Scarabelli T, Chen-Scarabelli C, Dioguardi FS., Essential Amino Acids-Rich Diet Increases Cardiomyocytes Protection in Doxorubicin-Treated Mice, Nutrients. 2023 May 12;15(10):2287. doi: 10.3390/nu15102287.

Bruce, A. C., & Peirce, S. M. (2012)., Exogenous thrombin delivery promotes collateral capillary arterialization and tissue reperfusion in the murine spinotrapezius muscle ischemia model., Microcirculation (New York, N.Y.: 1994), 19(2), 143-154. doi:10.1111/j.1549-8719.2011.00138.x [doi]

Antonioni A, Dimauro I, Fantini C, Barone R, Macaluso F, Di Felice V, Caporossi D., ÎąB-crystallin response to a pro-oxidant non-cytotoxic environment in murine cardiac cells: An "in vitro" and "in vivo" study, Free Radic Biol Med. 2020 May 20;152:301-312. doi: 10.1016/j.freeradbiomed.2020.03.013. Epub 2020 Mar 26.

Schiviz, A., Magirr, D., Leidenmuhler, P., Schuster, M., Muchitsch, E. M., Hollriegl, W., & Subcommittee on Animal Models. (2014)., Influence of genetic background on bleeding phenotype in the tail-tip bleeding model and recommendations for standardization: Communication from the SSC of the ISTH., Journal of Thrombosis and Haemostasis : JTH, 12(11), 1940-1942. doi:10.1111/jth.12700 [doi]

Kolosowska N, Gotkiewicz M, Dhungana H, Giudice L, Giugno R, Box D, Huuskonen MT, Korhonen P, Scoyni F, Kanninen KM, YlĂ¤-Herttuala S, Turunen TA, Turunen MP, Koistinaho J, Malm T., Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation, J Neuroinflammation. 2020 Jun 19;17(1):194. doi: 10.1186/s12974-020-01870-w.

Stohr, R., Mavilio, M., Marino, A., Casagrande, V., Kappel, B., Mollmann, J., . . . Federici, M. (2015), ITCH modulates SIRT6 and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE null mice., Scientific Reports, 5, 9023. doi:10.1038/srep09023 [doi]

Bigelman E, Pasmanik-Chor M, Dassa B, Itkin M, Malitsky S, Dorot O, Pichinuk E, Kleinberg Y, Keren G, Entin-Meer M., Kynurenic acid, a key L-tryptophan-derived metabolite, protects the heart from an ischemic damage, PLoS One. 2023 Aug 24;18(8):e0275550. doi: 10.1371/journal.pone.0275550. eCollection 2023.

De Hoog, V. C., Timmers, L., Van Duijvenvoorde, A., De Jager, S. C., Van Middelaar, B. J., Smeets, M. B., . . . De Kleijn, D. P. (2014), Leucocyte expression of complement C5a receptors exacerbates infarct size after myocardial reperfusion injury, Cardiovascular Research, 103(4), 521-529. doi:10.1093/cvr/cvu153 [doi]

Itzhar A, Yosef G, Eilon-Ashkenazy M, Shmidov Y, Gil H, Lacham-Hartman S, Elyagon S, Etzion S, Bitton R, Cohen S, Etzion Y, Papo N., Potent inhibition of MMP-9 by a novel sustained-release platform attenuates left ventricular remodeling following myocardial infarction, J Control Release. 2023 Dec;364:246-260. doi: 10.1016/j.jconrel.2023.10.033. Epub 2023 Oct 31.

Turner, J. K., McAllister, M. M., Xu, J. L., & Tapping, R. I. (2008)., The resistance of BALB/cJ mice to yersinia pestis maps to the major histocompatibility complex of chromosome 17., Infection and Immunity, 76(9), 4092-4099. doi:10.1128/IAI.00488-08 [doi]

COVID-19

Tan T K, Rijal P, Rahikainen R, Keeble A H, Schimanski L, Hussain S, Harvey R, et al., A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses, bioRxiv 2020.08.31.275701; doi: https://doi.org/10.1101/2020.08.31.275701

Dinnon KH 3rd, Leist SR, Schäfer A, Edwards CE, Martinez DR, Montgomery SA, West A, Yount BL Jr, Hou YJ, Adams LE, Gully KL, Brown AJ, Huang E, Bryant MD, Choong IC, Glenn JS, Gralinski LE, Sheahan TP, Baric RS., A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures, Nature. 2020 Oct;586(7830):560-566. doi: 10.1038/s41586-020-2708-8. Epub 2020 Aug 27.

Gene therapy

Qiu M, Li G, Wang P, Li X, Lai F, Luo R, Liu B, Lin J., aarF domain containing kinase 5 gene promotes invasion and migration of lung cancer cells through ADCK5-SOX9-PTTG1 pathway, Exp Cell Res. 2020 Jul 1;392(1):112002. doi: 10.1016/j.yexcr.2020.112002. Epub 2020 Apr 8.

Lampe, J., Bossow, S., Weiland, T., Smirnow, I., Lehmann, R., Neubert, W., . . . Lauer, U. M. (2013)., An armed oncolytic measles vaccine virus eliminates human hepatoma cells independently of apoptosis., Gene Therapy, 20(11), 1033-1041. doi:10.1038/gt.2013.28 [doi]

Tiwari A, Iida M, Kosnopfel C, Abbariki M, Menegakis A, Fehrenbacher B, Maier J, Schaller M, Brucker SY, Wheeler DL, Harari PM, Rothbauer U, Schittek B, Zips D, Toulany M., Blocking Y-Box Binding Protein-1 through Simultaneous Targeting of PI3K and MAPK in Triple Negative Breast Cancers, Cancers (Basel). 2020 Sep 29;12(10):2795. doi: 10.3390/cancers12102795.

Feichtinger, G. A., Hacobian, A., Hofmann, A. T., Wassermann, K., Zimmermann, A., van Griensven, M., & Redl, H. (2014)., Constitutive and inducible co-expression systems for non-viral osteoinductive gene therapy., European Cells & Materials, 27, 166-84; discussion 184. doi:vol027a13 [pii]

McCarthy GA, Di Niro R, Finan JM, Jain A, Guo Y, Wyatt CR, Guimaraes AR, Waugh TA, Keith D, Morgan TK, Sears RC, Brody JR., Deletion of the mRNA stability factor ELAVL1 (HuR) in pancreatic cancer cells disrupts the tumor microenvironment integrity., NAR Cancer. 2023 Apr 19;5(2):zcad016. doi: 10.1093/narcan/zcad016. eCollection 2023 Jun.

Gentschev, I., Muller, M., Adelfinger, M., Weibel, S., Grummt, F., Zimmermann, M., . . . Szalay, A. A. (2011)., Efficient colonization and therapy of human hepatocellular carcinoma (HCC) using the oncolytic vaccinia virus strain GLV-1h68., PloS One, 6(7), e22069. doi:10.1371/journal.pone.0022069 [doi]

Arruabarrena-Aristorena A, Maag JLV, Kittane S, Cai Y, Karthaus WR, Ladewig E, Park J, Kannan S, Ferrando L, Cocco E, Ho SY, Tan DS, Sallaku M, Wu F, Acevedo B, Selenica P, Ross DS, Witkin M, Sawyers CL, Reis-Filho JS, Verma CS, Jauch R, Koche R, Baselga J, Razavi P, Toska E, Scaltriti M., FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer, Cancer Cell. 2020 Oct 12;38(4):534-550.e9. doi: 10.1016/j.ccell.2020.08.003. Epub 2020 Sep 3.

Yu, L., Liang, Y., Cao, X., Wang, X., Gao, H., Lin, S. Y., . . . Li, K. (2017), Identification of MYST3 as a novel epigenetic activator of ERalpha frequently amplified in breast cancer., Oncogene, 36(20), 2910-2918. doi:10.1038/onc.2016.433 [doi]

Unzu, C., Melero, I., Morales-Kastresana, A., Sampedro, A., Serrano-Mendioroz, I., Azpilikueta, A., . . . Fontanellas, A. (2014), Innate functions of immunoglobulin M lessen liver gene transfer with helper-dependent adenovirus, PloS One, 9(1), e85432. doi:10.1371/journal.pone.0085432 [doi]

Dowaidar, M., Abdelhamid, H. N., Hallbrink, M., Freimann, K., Kurrikoff, K., Zou, X., & Langel, U. (2017)., Magnetic nanoparticle assisted self-assembly of cell penetrating peptides-oligonucleotides complexes for gene delivery, Scientific Reports, 7(1), 9159-017-09803-z. doi:10.1038/s41598-017-09803-z [doi]

Dinami R, Pompili L, Petti E, Porru M, D'Angelo C, Di Vito S, Rizzo A, Campani V, De Rosa G, Bruna A, Serra V, Mano M, Giacca M, Leonetti C, Ciliberto G, Tarsounas M, Stoppacciaro A, Schoeftner S, Biroccio A., MiR-182-3p targets TRF2 and impairs tumor growth of triple-negative breast cancer., EMBO Mol Med. 2023 Jan 11;15(1):e16033. doi: 10.15252/emmm.202216033. Epub 2022 Nov 25.

Kim SS, Doherty C, Moghe M, Rait A, Pirollo KF, Harford JB, Chang EH., Nanomedicine-Based Gene Delivery for a Truncated Tumor Suppressor RB94 Promotes Lung Cancer Immunity, Cancers (Basel). 2022 Oct 18;14(20):5092. doi: 10.3390/cancers14205092.

Ady, J. W., Johnsen, C., Mojica, K., Heffner, J., Love, D., Pugalenthi, A., . . . Fong, Y. (2015)., Oncolytic gene therapy with recombinant vaccinia strain GLV-2b372 efficiently kills hepatocellular carcinoma., Surgery, 158(2), 331-338. doi:10.1016/j.surg.2015.03.044 [doi]

Veiman, K. L., Kunnapuu, K., Lehto, T., Kiisholts, K., Parn, K., Langel, U., & Kurrikoff, K. (2015)., PEG shielded MMP sensitive CPPs for efficient and tumor specific gene delivery in vivo., Journal of Controlled Release : Official Journal of the Controlled Release Society, 209, 238-247. doi:10.1016/j.jconrel.2015.04.038 [doi]

Croessmann, S., Wong, H. Y., Zabransky, D. J., Chu, D., Rosen, D. M., Cidado, J., . . . Park, B. H. (2017)., PIK3CA mutations and TP53 alterations cooperate to increase cancerous phenotypes and tumor heterogeneity., Breast Cancer Research and Treatment, 162(3), 451-464. doi:10.1007/s10549-017-4147-2 [doi]

Hollevoet, K., De Smidt, E., Geukens, N., & Declerck, P. (2018), Prolonged in vivo expression and anti-tumor response of DNA-based anti-HER2 antibodies, Oncotarget, 9(17), 13623-13636. doi:10.18632/oncotarget.24426 [doi]

Kaliberov, S. A., Kaliberova, L. N., Yan, H., Kapoor, V., & Hallahan, D. E. (2016)., Retargeted adenoviruses for radiation-guided gene delivery., Cancer Gene Therapy, 23(9), 303-314. doi:10.1038/cgt.2016.32 [doi]

Shapira, S., Shapira, A., Kazanov, D., Hevroni, G., Kraus, S., & Arber, N. (2017)., Selective eradication of cancer cells by delivery of adenovirus-based toxins., Oncotarget, 8(24), 38581-38591. doi:10.18632/oncotarget.16934 [doi]

Anders, N. M., Liu, J., Wanjiku, T., Giovinazzo, H., Zhou, J., Vaghasia, A., . . . Rudek, M. A. (2016)., Simultaneous quantitative determination of 5-aza-2'-deoxycytidine genomic incorporation and DNA demethylation by liquid chromatography tandem mass spectrometry as exposure-response measures of nucleoside analog DNA methyltransferase inhibitors, Journal of Chromatography.B, Analytical Technologies in the Biomedical and Life Sciences, 1022, 38-45. doi:S1570-0232(16)30178-7 [pii]

Feichtinger, G. A., Hofmann, A. T., Slezak, P., Schuetzenberger, S., Kaipel, M., Schwartz, E., . . . Redl, H. (2014)., Sonoporation increases therapeutic efficacy of inducible and constitutive BMP2/7 in vivo gene delivery., Human Gene Therapy Methods, 25(1), 57-71. doi:10.1089/hgtb.2013.113 [doi]

Abel, T., El Filali, E., Waern, J., Schneider, I. C., Yuan, Q., Munch, R. C., . . . Buchholz, C. J. (2013)., Specific gene delivery to liver sinusoidal and artery endothelial cells, Blood, 122(12), 2030-2038. doi:10.1182/blood-2012-11-468579 [doi]

Hou R, Yu Y, Sluter MN, Li L, Hao J, Fang J, Yang J, Jiang J., Targeting EP2 receptor with multifaceted mechanisms for high-risk neuroblastoma, Cell Rep. 2022 Jun 21;39(12):111000. doi: 10.1016/j.celrep.2022.111000.

Chatterjee S, Naidu GS, Hazan-Halevy I, Grobe H, Ezra A, Sharma P, Goldsmith M, Ramishetti S, Sprinzak D, Zaidel-Bar R, Peer D., Therapeutic gene silencing of CKAP5 leads to lethality in genetically unstable cancer cells., Sci Adv. 2023 Apr 5;9(14):eade4800. doi: 10.1126/sciadv.ade4800. Epub 2023 Apr 5.

Presutti, D., Ceccarelli, M., Micheli, L., Papoff, G., Santini, S., Samperna, S., . . . Tirone, F. (2018)., Tis21-gene therapy inhibits medulloblastoma growth in a murine allograft model., PloS One, 13(3), e0194206. doi:10.1371/journal.pone.0194206 [doi]

Nomikou, N., Feichtinger, G. A., Saha, S., Nuernberger, S., Heimel, P., Redl, H., & McHale, A. P. (2018)., Ultrasound-responsive gene-activated matrices for osteogenic gene therapy using matrix-assisted sonoporation., Journal of Tissue Engineering and Regenerative Medicine, 12(1), e250-e260. doi:10.1002/term.2406 [doi]

General studies

Waugh CM, Mousavizadeh R, Lee J, Screen HRC, Scott A., Mild hypercholesterolemia impacts achilles sub-tendon mechanical properties in young rats, BMC Musculoskelet Disord. 2023 Apr 12;24(1):282. doi: 10.1186/s12891-023-06375-0.

Choi YH, Zhang C, Liu Z, Tu MJ, Yu AX, Yu AM., A Novel Integrated Pharmacokinetic-Pharmacodynamic Model to Evaluate Combination Therapy and Determine In Vivo Synergism, J Pharmacol Exp Ther. 2021 Jun;377(3):305-315. doi: 10.1124/jpet.121.000584. Epub 2021 Mar 12.

Landgraf, L., Christner, C., Storck, W., Schick, I., Krumbein, I., Dahring, H., . . . Hilger, I. (2015), A plasma protein corona enhances the biocompatibility of Au@Fe3O4 janus particles, Biomaterials, 68, 77-88. doi:10.1016/j.biomaterials.2015.07.049 [doi]

Cook Sangar ML, Girard EJ, Hopping G, Yin C, Pakiam F, Brusniak MY, Nguyen E, Ruff R, Gewe MM, Byrnes-Blake K, Nairn NW, Miller DM, Mehlin C, Strand AD, Mhyre AJ, Correnti CE, Strong RK, Simon JA, Olson JM., A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure, Sci Transl Med. 2020 Mar 4;12(533):eaay1041. doi: 10.1126/scitranslmed.aay1041.

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Puigdelloses M, Garcia-Moure M, Labiano S, Laspidea V, Gonzalez-Huarriz M, Zalacain M, Marrodan L, Martinez-Velez N, De la Nava D, Ausejo I, Hervás-Stubbs S, Herrador G, Chen Z, Hambardzumyan D, Patino Garcia A, Jiang H, Gomez-Manzano C, Fueyo J, Gállego Pérez-Larraya J, Alonso M., CD137 and PD-L1 targeting with immunovirotherapy induces a potent and durable antitumor immune response in glioblastoma models, J Immunother Cancer. 2021 Jul;9(7):e002644. doi: 10.1136/jitc-2021-002644.

Wedekind MF, Miller KE, Chen CY, Wang PY, Hutzen BJ, Currier MA, Nartker B, Roberts RD, Boon L, Conner J, LaHaye S, Kelly BJ, Gordon D, White P, Mardis ER, Cripe TP., Endogenous retrovirus envelope as a tumor-associated immunotherapeutic target in murine osteosarcoma, iScience. 2021 Jun 19;24(7):102759. doi: 10.1016/j.isci.2021.102759. eCollection 2021 Jul 23.

Verma B, Wesa A., Establishment of Humanized Mice from Peripheral Blood Mononuclear Cells or Cord Blood CD34+ Hematopoietic Stem Cells for Immune-Oncology Studies Evaluating New Therapeutic Agents, Curr Protoc Pharmacol. 2020 Jun;89(1):e77. doi: 10.1002/cpph.77.

Alvero AB, Fox A, Madina BR, Krady MM, Gogoi R, Chehade H, Nakaar V, Almassian B, Yarovinsky TO, Rutherford T, Mor G., Immune modulation of innate and adaptive responses restores immune surveillance and establishes anti-tumor immunological memory., Cancer Immunol Res. 2023 Dec 11. doi: 10.1158/2326-6066.CIR-23-0127. [Epub ahead of print]

Ahmed MSU, Lord BD, Adu Addai B, Singhal SK, Gardner K, Salam AB, Ghebremedhin A, White J, Mahmud I, Martini R, Bedi D, Lin H, Jones JD, Karanam B, Dean-Colomb W, Grizzle W, Wang H, Davis M, Yates CC., Immune Profile of Exosomes in African American Breast Cancer Patients Is Mediated by Kaiso/THBS1/CD47 Signaling., Cancers (Basel). 2023 Apr 13;15(8). pii: 2282. doi: 10.3390/cancers15082282.

Li M, Wei W, Barnhart TE, Jiang D, Cao T, Fan K, Engle JW, Liu J, Chen W, Cai W., ImmunoPET/NIRF/Cerenkov multimodality imaging of ICAM-1 in pancreatic ductal adenocarcinoma, Eur J Nucl Med Mol Imaging. 2021 Aug;48(9):2737-2748. doi: 10.1007/s00259-021-05216-3. Epub 2021 Feb 3.

Landau S, Newman A, Edri S, Michael I, Ben-Shaul S, Shandalov Y, Ben-Arye T, Kaur P, Zheng MH, Levenberg S., Investigating lymphangiogenesis in vitro and in vivo using engineered human lymphatic vessel networks, Proc Natl Acad Sci U S A. 2021 Aug 3;118(31):e2101931118. doi: 10.1073/pnas.2101931118.

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Nair, Vidhya R; Malladi, Srinivas;, Mouse Models to Study Natural Killer Cell-Mediated Immunosurveillance and Metastatic Latency., Methods in molecular biology (Clifton, N.J.) Vol.1884, 2019

Hedberg J, Studebaker A, Smith L, Chen CY, Westfall JJ, Cam M, Gross A, Hernandez-Aguirre I, Martin A, Kim D, Dhital R, Kim Y, Roberts RD, Cripe TP, Mardis ER, Cassady KA, Leonard J, Miller KE., Oncolytic virus-driven immune remodeling revealed in mouse medulloblastomas at single cell resolution., Mol Ther Oncolytics. 2023 Jul 19;30:39-55. doi: 10.1016/j.omto.2023.07.006. eCollection 2023 Sep 21.

Jacobson, O., Li, Q., Chen, H., Niu, G., Kiesewetter, D. O., Xu, L., . . . Chen, X. (2017)., PET-guided evaluation and optimization of internalized antibody-drug conjugates targeting erythropoietin-producing hepatoma A2 receptor., Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine, 58(11), 1838-1844. doi:10.2967/jnumed.117.192245 [doi]

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Hsiao, H. C., Fan, X., Jordan, R. E., Zhang, N., & An, Z. (2018)., Proteolytic single hinge cleavage of pertuzumab impairs its fc effector function and antitumor activity in vitro and in vivo, Breast Cancer Research : BCR, 20(1), 43-018-0972-4. doi:10.1186/s13058-018-0972-4 [doi]

Hutzen, B., Chen, C. Y., Wang, P. Y., Sprague, L., Swain, H. M., Love, J., . . . Cripe, T. P. (2017)., TGF-beta inhibition improves oncolytic herpes viroimmunotherapy in murine models of rhabdomyosarcoma, Molecular Therapy Oncolytics, 7, 17-26. doi:10.1016/j.omto.2017.09.001 [doi]

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Maitra, R., Augustine, T., Dayan, Y., Chandy, C., Coffey, M., & Goel, S. (2017)., Toll like receptor 3 as an immunotherapeutic target for KRAS mutated colorectal cancer, Oncotarget, 8(21), 35138-35153. doi:10.18632/oncotarget.16812 [doi]

Rogovskyy, A. S., & Bankhead, T. (2013)., Variable VlsE is critical for host reinfection by the lyme disease spirochete, PloS One, 8(4), e61226. doi:10.1371/journal.pone.0061226 [doi]

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Neuroscience

Berenji Ardestani, Simin; Matchkov, Vladimir V; Eftedal, Ingrid; Pedersen, Michael;, A Single Simulated Heliox Dive Modifies Endothelial Function in the Vascular Wall of ApoE Knockout Male Rats More Than Females., Frontiers in physiology Vol.10, 2019

Phillips, Evan H; Chang, Mandy S; Gorman, Sydney; Qureshi, Hamna J; Ejendal, Karin F K; Kinzer-Ursem, Tamara L; Blaize, A Nicole; Goergen, Craig J;, Angiotensin II Infusion Does Not Cause Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Rats., Journal of vascular research Vol.55, 2018

Cornelissen, Anne; Simsekyilmaz, Sakine; Liehn, Elisa; Rusu, Mihaela; Schaaps, Nicole; Afify, Mamdouh; Florescu, Roberta; Almalla, Mohammad; Borinski, Mauricio; Vogt, Felix;, Apolipoprotein E deficient rats generated via zinc-finger nucleases exhibit pronounced in-stent restenosis., Scientific reports Vol.9, 2019

Rune, Ida; Rolin, Bidda; Lykkesfeldt, Jens; Nielsen, Dennis Sandris; Krych, Lukasz; Kanter, Jenny E; Bornfeldt, Karin E; Kihl, Pernille; Buschard, Karsten; Josefsen, Knud; Fels, Johannes Josef; Mortensen, Alan; Christoffersen, Berit; Kirk, Rikke Kaae; Hansen, Axel Kornerup;, Long-term Western diet fed apolipoprotein E-deficient rats exhibit only modest early atherosclerotic characteristics., Scientific reports Vol.8, 2018

Hohl, Mathias; Linz, Dominik; Fries, Peter; MĂźller, Andreas; Stroeder, Jonas; Urban, Daniel; Speer, Thimoteus; Geisel, JĂźrgen; Hummel, BjĂśrn; Laufs, Ulrich; Schirmer, Stephan H; BĂśhm, Michael; Mahfoud, Felix;, Modulation of the sympathetic nervous system by renal denervation prevents reduction of aortic distensibility in atherosclerosis prone ApoE-deficient rats., Journal of translational medicine Vol.14, 2016

Nguyen TD, Hållenius FF, Lin X, Nyman M, Prykhodko O., Monobutyrin and Monovalerin Affect Brain Short-Chain Fatty Acid Profiles and Tight-Junction Protein Expression in ApoE-Knockout Rats Fed High-Fat Diets, Nutrients. 2020 Apr 24;12(4):1202. doi: 10.3390/nu12041202.

Obesity

Pohjanvirta, R., Karppinen, I., Galbán-Velázquez, S., Esteban, J., Hĺkansson, H., Sankari, S., & Lindén, J., Effects of a high-fat diet and global aryl hydrocarbon receptor deficiency on energy balance and liver retinoid status in male Sprague-Dawley rats, The Journal of Nutritional Biochemistry 95 (2021): 108762.

Oncology

Siddique AB, Kilgore PCSR, Tajmim A, Singh SS, Meyer SA, Jois SD, Cvek U, Trutschl M, Sayed KAE., (-)-Oleocanthal as a Dual c-MET-COX2 Inhibitor for the Control of Lung Cancer, Nutrients. 2020 Jun 11;12(6):1749. doi: 10.3390/nu12061749.

Jiménez-Mora E, Gallego B, Díaz-Gago S, Lasa M, Baquero P, Chiloeches A., (V600E)BRAF Inhibition Induces Cytoprotective Autophagy through AMPK in Thyroid Cancer Cells, Int J Mol Sci. 2021 Jun 3;22(11):6033. doi: 10.3390/ijms22116033.

Masoodi, K. Z., Ramos Garcia, R., Pascal, L. E., Wang, Y., Ma, H. M., O'Malley, K., . . . Wang, Z. (2013)., 5alpha-reductase inhibition suppresses testosterone-induced initial regrowth of regressed xenograft prostate tumors in animal models., Endocrinology, 154(7), 2296-2307. doi:10.1210/en.2012-2077 [doi]

Yang, Hailing; Shu, Zhang; Jiang, Yongying; Mao, Weiqun; Pang, Lan; Redwood, Abena; Jeter-Jones, Sabrina L; Jennings, Nicholas B; Ornelas, Argentina; Zhou, Jinhua; Rodriguez-Aguayo, Cristian; Bartholomeusz, Geoffrey; Iles, LaKesla R; Zacharias, Niki M; Millward, Steven W; Lopez-Berestein, Gabriel; Le, Xiao-Feng; Ahmed, Ahmed A; Piwnica-Worms, Helen; Sood, Anil K; Bast, Robert C; Lu, Zhen, 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase-2 Regulates TP53-Dependent Paclitaxel Sensitivity in Ovarian and Breast Cancers, Clinical cancer research : an official journal of the American Association for Cancer Research Vol.25, 2019

Marayati R, Bownes LV, Stafman LL, Williams AP, Quinn CH, Atigadda V, Aye JM, Stewart JE, Yoon KJ, Beierle EA., 9-cis-UAB30, a novel rexinoid agonist, decreases tumorigenicity and cancer cell stemness of human neuroblastoma patient-derived xenografts, Transl Oncol. 2021 Jan;14(1):100893. doi: 10.1016/j.tranon.2020.100893. Epub 2020 Sep 30.

Deng, Y., Wang, Z., Zhang, F., Qiao, M., Yan, Z., Wei, Q., . . . Zhang, J. (2016), A blockade of IGF signaling sensitizes human ovarian cancer cells to the anthelmintic niclosamide-induced anti-proliferative and anticancer activities, Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 39(3), 871-888. doi:10.1159/000447797 [doi]

Kuznik NC, Solozobova V, Lee II, Jung N, Yang L, Nienhaus K, Ntim EA, Rottenberg JT, Muhle-Goll C, Kumar AR, Peravali R, Gräßle S, Gourain V, Deville C, Cato L, Neeb A, Dilger M, Cramer von Clausbruch CA, Weiss C, Kieffer B, Nienhaus GU, Brown M, Bräse S, Cato ACB., A chemical probe for BAG1 targets androgen receptor-positive prostate cancer through oxidative stress signaling pathway, iScience. 2022 Mar 31;25(5):104175. doi: 10.1016/j.isci.2022.104175. eCollection 2022 May 20.

Zhao Y, Wang C, Goel A., A combined treatment with melatonin and andrographis promotes autophagy and anticancer activity in colorectal cancer, Carcinogenesis. 2022 Apr 25;43(3):217-230. doi: 10.1093/carcin/bgac008.

Luderer, M. J., Muz, B., de la Puente, P., Chavalmane, S., Kapoor, V., Marcelo, R., . . . Azab, A. K. (2016), A hypoxia-targeted boron neutron capture therapy agent for the treatment of glioma., Pharmaceutical Research, 33(10), 2530-2539. doi:10.1007/s11095-016-1977-2 [doi]

Tian Q, Zhang P, Wang Y, Si Y, Yin D, Weber CR, Fishel ML, Pollok KE, Qiu B, Xiao F, Chong AS., A novel triptolide analog downregulates NF-kB and induces mitochondrial apoptosis pathways in human pancreatic cancer., Elife. 2023 Oct 25;12. pii: e85862. doi: 10.7554/eLife.85862. [Epub ahead of print]

Shivange G, Mondal T, Lyerly E, Bhatnagar S, Landen CN, Reddy S, Kim J, Doan B, Riddle P, Tushir-Singh J., A patch of positively charged residues regulates the efficacy of clinical DR5 antibodies in solid tumors, Cell Rep. 2021 Nov 2;37(5):109953. doi: 10.1016/j.celrep.2021.109953.

Hight, M. R., Cheung, Y. Y., Nickels, M. L., Dawson, E. S., Zhao, P., Saleh, S., . . . Manning, H. C. (2014)., A peptide-based positron emission tomography probe for in vivo detection of caspase activity in apoptotic cells., Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 20(8), 2126-2135. doi:10.1158/1078-0432.CCR-13-2444 [doi]

Dey, J., Kerwin, W. S., Grenley, M. O., Casalini, J. R., Tretyak, I., Ditzler, S. H., . . . Klinghoffer, R. A. (2016), A platform for rapid, quantitative assessment of multiple drug combinations simultaneously in solid tumors in vivo., PloS One, 11(6), e0158617. doi:10.1371/journal.pone.0158617 [doi]

Green, D. J., Orgun, N. N., Jones, J. C., Hylarides, M. D., Pagel, J. M., Hamlin, D. K., . . . Press, O. W. (2014), A preclinical model of CD38-pretargeted radioimmunotherapy for plasma cell malignancies., Cancer Research, 74(4), 1179-1189. doi:10.1158/0008-5472.CAN-13-1589 [doi]

Yang, Lu; Li, Yun; Bhattacharya, Arup; Zhang, Yuesheng;, A recombinant human protein targeting HER2 overcomes drug resistance in HER2-positive breast cancer., Science translational medicine Vol.11, 2019

Neiveyans, Madeline; Melhem, Rana; Arnoult, Christophe; Bourquard, Thomas; Jarlier, Marta; Busson, Muriel; Laroche, Adrien; Cerutti, Martine; PugniĂ¨re, Martine; Ternant, David; Gaborit, NadĂ¨ge; ChardĂ¨s, Thierry; Poupon, Anne; Gouilleux-Gruart, ValĂŠrie; PĂ¨legrin, Andre; Poul, Marie-Alix;, A recycling anti-transferrin receptor-1 monoclonal antibody as an efficient therapy for erythroleukemia through target up-regulation and antibody-dependent cytotoxic effector functions, mAbs Vol.11, 2019

Santich BH, Cheal SM, Ahmed M, McDevitt MR, Ouerfelli O, Yang G, Veach DR, Fung EK, Patel M, Burnes Vargas D, Malik AA, Guo HF, Zanzonico PB, Monette S, Michel AO, Rudin CM, Larson SM, Cheung NK., A Self-Assembling and Disassembling (SADA) Bispecific Antibody (BsAb) Platform for Curative Two-step Pretargeted Radioimmunotherapy, Clin Cancer Res. 2020 Sep 21. doi: 10.1158/1078-0432.CCR-20-2150. Online ahead of print.

Santich BH, Cheal SM, Ahmed M, McDevitt MR, Ouerfelli O, Yang G, Veach DR, Fung EK, Patel M, Burnes Vargas D, Malik AA, Guo HF, Zanzonico PB, Monette S, Michel AO, Rudin CM, Larson SM, Cheung NK., A Self-Assembling and Disassembling (SADA) Bispecific Antibody (BsAb) Platform for Curative Two-step Pretargeted Radioimmunotherapy, Clin Cancer Res. 2021 Jan 15;27(2):532-541. doi: 10.1158/1078-0432.CCR-20-2150. Epub 2020 Sep 21.

Pattarawat P, Hunt JT, Poloway J, Archibald CJ, Wang HR., A triple combination gemcitabine?+?romidepsin?+?cisplatin to effectively control triple-negative breast cancer tumor development, recurrence, and metastasis, Cancer Chemother Pharmacol. 2021 Sep;88(3):415-425. doi: 10.1007/s00280-021-04298-y. Epub 2021 May 27.

Roy, L. D., Dillon, L. M., Zhou, R., Moore, L. J., Livasy, C., El-Khoury, J. M., . . . Mukherjee, P. (2017)., A tumor specific antibody to aid breast cancer screening in women with dense breast tissue., Genes & Cancer, 8(3-4), 536-549. doi:10.18632/genesandcancer.134 [doi]

Kim, S. S., Rait, A., Kim, E., Pirollo, K. F., & Chang, E. H. (2015)., A tumor-targeting p53 nanodelivery system limits chemoresistance to temozolomide prolonging survival in a mouse model of glioblastoma multiforme., Nanomedicine : Nanotechnology, Biology, and Medicine, 11(2), 301-311. doi:10.1016/j.nano.2014.09.005 [doi]

Formisano, Luigi; Lu, Yao; Servetto, Alberto; Hanker, Ariella B; Jansen, Valerie M; Bauer, Joshua A; Sudhan, Dhivya R; Guerrero-Zotano, Angel L; Croessmann, Sarah; Guo, Yan; Ericsson, Paula Gonzalez; Lee, Kyung-Min; Nixon, Mellissa J; Schwarz, Luis J; Sanders, Melinda E; Dugger, Teresa C; Cruz, Marcelo Rocha; Behdad, Amir; Cristofanilli, Massimo; Bardia, Aditya; OShaughnessy, Joyce; Nagy, Rebecca J; Lanman, Richard B; Solovieff, Nadia; He, Wei; Miller, Michelle; Su, Fei; Shyr, Yu; Mayer, Ingrid A; Balko, Justin M; Arteaga, Carlos L;, Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer., Nature communications Vol.10, 2019

Li M, Li J, Guo X, Pan H, Zhou Q., Absence of HTATIP2 Expression in A549 Lung Adenocarcinoma Cells Promotes Tumor Plasticity in Response to Hypoxic Stress, Cancers (Basel). 2020 Jun 11;12(6):1538. doi: 10.3390/cancers12061538.

Tansi, F. L., Ruger, R., Bohm, C., Steiniger, F., Kontermann, R. E., Teichgraeber, U. K., . . . Hilger, I. (2017)., Activatable bispecific liposomes bearing fibroblast activation protein directed single chain fragment/Trastuzumab deliver encapsulated cargo into the nuclei of tumor cells and the tumor microenvironment simultaneously., Acta Biomaterialia, 54, 281-293. doi:S1742-7061(17)30203-9 [pii]

Young, N. R., Soneru, C., Liu, J., Grushko, T. A., Hardeman, A., Olopade, O. I., . . . Cohen, E. E. (2015)., Afatinib efficacy against squamous cell carcinoma of the head and neck cell lines in vitro and in vivo., Targeted Oncology, 10(4), 501-508. doi:10.1007/s11523-014-0353-6 [doi]

Ziegler, J., Bastian, A., Lerner, M., Bailey-Downs, L., Saunders, D., Smith, N., . . . Towner, R. A. (2017)., AG488 as a therapy against gliomas., Oncotarget, 8(42), 71833-71844. doi:10.18632/oncotarget.18284 [doi]

Gomes AP, Ilter D, Low V, Endress JE, Fernández-García J, Rosenzweig A, Schild T, Broekaert D, Ahmed A, Planque M, Elia I, Han J, Kinzig C, Mullarky E, Mutvei AP, Asara J, de Cabo R, Cantley LC, Dephoure N, Fendt SM, Blenis J., Age-induced accumulation of methylmalonic acid promotes tumour progression, Nature. 2020 Sep;585(7824):283-287. doi: 10.1038/s41586-020-2630-0. Epub 2020 Aug 19.

Dunn S, Eberlein C, Yu J, Gris-Oliver A, Ong SH, Yelland U, Cureton N, Staniszewska A, McEwen R, Fox M, Pilling J, Hopcroft P, Coker EA, Jaaks P, Garnett MJ, Isherwood B, Serra V, Davies BR, Barry ST, Lynch JT, Yusa K., AKT-mTORC1 reactivation is the dominant resistance driver for PI3Kβ/AKT inhibitors in PTEN-null breast cancer and can be overcome by combining with Mcl-1 inhibitors, Oncogene. 2022 Nov;41(46):5046-5060. doi: 10.1038/s41388-022-02482-9. Epub 2022 Oct 14.

Sun Y, Meyers BA, Czako B, Leonard P, Mseeh F, Harris AL, Wu Q, Johnson S, Parker CA, Cross JB, Di Francesco ME, Bivona BJ, Bristow CA, Burke JP, Carrillo CC, Carroll CL, Chang Q, Feng N, Gao G, Gera S, Giuliani V, Huang JK, Jiang Y, Kang Z, Kovacs JJ, Liu CY, Lopez AM, Ma X, Mandal PK, McAfoos T, Miller MA, Mullinax RA, Peoples M, Ramamoorthy V, Seth S, Spencer ND, Suzuki E, Williams CC, Yu SS, Zuniga AM, Draetta GF, Marszalek JR, Heffernan TP, Kohl NE, Jones P., Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib, Cancer Res. 2020 Nov 1;80(21):4840-4853. doi: 10.1158/0008-5472.CAN-20-1634. Epub 2020 Sep 14.

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Miles, L. A., Burga, L. N., Gardner, E. E., Bostina, M., Poirier, J. T., & Rudin, C. M. (2017)., Anthrax toxin receptor 1 is the cellular receptor for seneca valley virus., The Journal of Clinical Investigation, 127(8), 2957-2967. doi:10.1172/JCI93472 [doi]

Moody, G., Belmontes, B., Masterman, S., Wang, W., King, C., Murawsky, C., . . . Beltran, P. J. (2016)., Antibody-mediated neutralization of autocrine Gas6 inhibits the growth of pancreatic ductal adenocarcinoma tumors in vivo, International Journal of Cancer, 139(6), 1340-1349. doi:10.1002/ijc.30180 [doi]

Tabernero, J., Chawla, S. P., Kindler, H., Reckamp, K., Chiorean, E. G., Azad, N. S., . . . Baselga, J. (2015)., Anticancer activity of the type I insulin-like growth factor receptor antagonist, ganitumab, in combination with the death receptor 5 agonist, conatumumab., argeted Oncology, 10(1), 65-76. doi:10.1007/s11523-014-0315-z [doi]

Li, X., Wu, J. B., Chung, L. W., & Huang, W. C. (2015)., Anti-cancer efficacy of SREBP inhibitor, alone or in combination with docetaxel, in prostate cancer harboring p53 mutations., Oncotarget, 6(38), 41018-41032. doi:10.18632/oncotarget.5879 [doi]

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Dauchy, R. T., Xiang, S., Mao, L., Brimer, S., Wren, M. A., Yuan, L., . . . Hill, S. M. (2014)., Circadian and melatonin disruption by exposure to light at night drives intrinsic resistance to tamoxifen therapy in breast cancer., Cancer Research, 74(15), 4099-4110. doi:10.1158/0008-5472.CAN-13-3156 [doi]

Eschbach, R. S., Clevert, D. A., Hirner-Eppeneder, H., Ingrisch, M., Moser, M., Schuster, J., . . . Cyran, C. C. (2017)., Contrast-enhanced ultrasound with VEGFR2-targeted microbubbles for monitoring regorafenib therapy effects in experimental colorectal adenocarcinomas in rats with DCE-MRI and immunohistochemical validation., PloS One, 12(1), e0169323. doi:10.1371/journal.pone.0169323 [doi]

Eschbach, R. S., Fendler, W. P., Kazmierczak, P. M., Hacker, M., Rominger, A., Carlsen, J., . . . Cyran, C. C. (2015)., Correlation of perfusion MRI and 18F-FDG PET imaging biomarkers for monitoring regorafenib therapy in experimental colon carcinomas with immunohistochemical validation., PloS One, 10(2), e0115543. doi:10.1371/journal.pone.0115543 [doi]

Rau, R. E., Rodriguez, B. A., Luo, M., Jeong, M., Rosen, A., Rogers, J. H., . . . Goodell, M. A. (2016)., DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia., Blood, 128(7), 971-981. doi:10.1182/blood-2015-11-684225 [doi]

Duong le, T., Wesolowski, G. A., Leung, P., Oballa, R., & Pickarski, M. (2014)., Efficacy of a cathepsin K inhibitor in a preclinical model for prevention and treatment of breast cancer bone metastasis. Molecular Cancer Therapeutics, 13(12), 2898-2909. doi:10.1158/1535-7163.MCT-14-0253 [doi], Molecular Cancer Therapeutics, 13(12), 2898-2909. doi:10.1158/1535-7163.MCT-14-0253 [doi]

Atkins, Ayelet; Burke, Mikhail; Samiezadeh, Saeid; Akens, Margarete K; Hardisty, Michael; Whyne, Cari M;, Elevated Microdamage Spatially Correlates with Stress in Metastatic Vertebrae, Annals of biomedical engineering Vol.47, 2019

Ghomashchi S, Clement A, Whyne CM, Akens MK., Establishment and Image based evaluation of a New Preclinical Rat Model of Osteoblastic Bone Metastases, Clin Exp Metastasis. 2022 Oct;39(5):833-840. doi: 10.1007/s10585-022-10175-6. Epub 2022 Jul 11.

Van de Sande, Leen; Willaert, Wouter; Cosyns, Sarah; De Clercq, Kaat; Shariati, Molood; Remaut, Katrien; Ceelen, Wim, Establishment of a rat ovarian peritoneal metastasis model to study pressurized intraperitoneal aerosol chemotherapy (PIPAC)., BMC cancer Vol.19, 2019

Halle, B., Thisgaard, H., Hvidsten, S., Dam, J. H., Aaberg-Jessen, C., Thykjaer, A. S., . . . Kristensen, B. W. (2015)., Estimation of tumor volumes by 11C-MeAIB and 18F-FDG PET in an orthotopic glioblastoma rat model., Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine, 56(10), 1562-1568. doi:10.2967/jnumed.115.162511 [doi]

Wise-Milestone, L., Akens, M. K., Rosol, T. J., Hojjat, S. P., Grynpas, M. D., & Whyne, C. M. (2012)., Evaluating the effects of mixed osteolytic/osteoblastic metastasis on vertebral bone quality in a new rat model., Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 30(5), 817-823. doi:10.1002/jor.21577 [doi]

Cyran, C. C., Fu, Y., Rogut, V., Chaopathomkul, B., Wendland, M. F., Shames, D. M., & Brasch, R. C. (2013)., Evaluation of a novel macromolecular cascade-polymer contrast medium for dynamic contrast-enhanced MRI monitoring of antiangiogenic bevacizumab therapy in a human melanoma model., Academic Radiology, 20(10), 1256-1263. doi:10.1016/j.acra.2013.07.010 [doi]

Li, S., Goins, B., Hrycushko, B. A., Phillips, W. T., & Bao, A. (2012)., Feasibility of eradication of breast cancer cells remaining in postlumpectomy cavity and draining lymph nodes following intracavitary injection of radioactive immunoliposomes., Molecular Pharmaceutics, 9(9), 2513-2522. doi:10.1021/mp300132f [doi]

Sakuma, S., Yu, J. Y., Quang, T., Hiwatari, K., Kumagai, H., Kao, S., . . . Pham, W. (2015)., Fluorescence-based endoscopic imaging of thomsen-friedenreich antigen to improve early detection of colorectal cancer. International Journal of Cancer., Journal International Du Cancer, 136(5), 1095-1103. doi:10.1002/ijc.29093 [doi]

Panella, C., Castellvi, Q., Moll, X., Quesada, R., Villanueva, A., Iglesias, M., . . . Burdio, F. (2017)., Focused transhepatic electroporation mediated by hypersaline infusion through the portal vein in rat model. preliminary results on differential conductivity., Radiology and Oncology, 51(4), 415-421. doi:10.1515/raon-2017-0051 [doi]

Shariati, Molood; Zhang, Heyang; Van de Sande, Leen; Descamps, Benedicte; Vanhove, Chris; Willaert, Wouter; Ceelen, Wim; De Smedt, Stefaan C; Remaut, Katrien, High Pressure Nebulization (PIPAC) Versus Injection for the Intraperitoneal Administration of mRNA Complexes, Pharmaceutical research Vol.36, 2019

Thisgaard, H., Halle, B., Aaberg-Jessen, C., Olsen, B. B., Therkelsen, A. S., Dam, J. H., . . . Kristensen, B. W. (2016)., Highly effective auger-electron therapy in an orthotopic glioblastoma xenograft model using convection-enhanced delivery., Theranostics, 6(12), 2278-2291. doi:10.7150/thno.15898 [doi]

Chaumeil, M. M., Ozawa, T., Park, I., Scott, K., James, C. D., Nelson, S. J., & Ronen, S. M. (2012)., Hyperpolarized 13C MR spectroscopic imaging can be used to monitor everolimus treatment in vivo in an orthotopic rodent model of glioblastoma., Neuroimage, 59(1), 193-201. doi:10.1016/j.neuroimage.2011.07.034 [doi]

Ghomashchi S, Whyne CM, Chinnery T, Habach F, Akens MK., Impact of radiofrequency ablation (RFA) on bone quality in a murine model of bone metastases, PLoS One. 2021 Sep 8;16(9):e0256076. doi: 10.1371/journal.pone.0256076. eCollection 2021.

Tokalov, S. V., Enghardt, W., & Abolmaali, N. (2010)., Improvement of radiation-mediated immunosuppression of human NSCLC tumour xenografts in a nude rat model., Journal of Biomedicine & Biotechnology, 2010, 580531. doi:10.1155/2010/580531 [doi]

Akens, M. K., Wise-Milestone, L., Won, E., Schwock, J., Yee, A. J., Wilson, B. C., & Whyne, C. M. (2014)., In vitro and in vivo effects of photodynamic therapy on metastatic breast cancer cells pre-treated with zoledronic acid., Photodiagnosis and Photodynamic Therapy, 11(3), 426-433. doi:10.1016/j.pdpdt.2014.04.002 [doi]

Verco, James; Johnston, William; Frost, Michael; Baltezor, Michael; Kuehl, Philip J; Lopez, Anita; Gigliotti, Andrew; Belinsky, Steven A; Wolff, Ronald; diZerega, Gere;, Inhaled Submicron Particle Paclitaxel (NanoPac) Induces Tumor Regression and Immune Cell Infiltration in an Orthotopic Athymic Nude Rat Model of Non-Small Cell Lung Cancer, Journal of aerosol medicine and pulmonary drug delivery Vol.32, 2019

Wise-Milestone, L., Akens, M. K., Lo, V. C., Yee, A. J., Wilson, B. C., & Whyne, C. M. (2012)., Local treatment of mixed osteolytic/osteoblastic spinal metastases: Is photodynamic therapy effective?, Breast Cancer Research and Treatment, 133(3), 899-908. doi:10.1007/s10549-011-1854-y [doi]

Kuhn, M. W., Hadler, M. J., Daigle, S. R., Koche, R. P., Krivtsov, A. V., Olhava, E. J., . . . Armstrong, S. A. (2015)., MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition., Haematologica, 100(5), e190-3. doi:10.3324/haematol.2014.115337 [doi]

Kazmierczak, P. M., Burian, E., Eschbach, R., Hirner-Eppeneder, H., Moser, M., Havla, L., . . . Cyran, C. C. (2015)., Monitoring cell death in regorafenib-treated experimental colon carcinomas using annexin-based optical fluorescence imaging validated by perfusion MRI., PloS One, 10(9), e0138452. doi:10.1371/journal.pone.0138452 [doi]

Hong D, Kim Y, Mushti C, Minami N, Wu J, Cherukuri MK, Swenson RE, Vigneron DB, Ronen SM., Monitoring response to a clinically relevant IDH inhibitor in glioma-Hyperpolarized (13)C magnetic resonance spectroscopy approaches., Neurooncol Adv. 2023 Nov 2;5(1):vdad143. doi: 10.1093/noajnl/vdad143. eCollection 2023 Jan-Dec.

Bechet, D., Auger, F., Couleaud, P., Marty, E., Ravasi, L., Durieux, N., . . . Barberi-Heyob, M. (2015)., Multifunctional ultrasmall nanoplatforms for vascular-targeted interstitial photodynamic therapy of brain tumors guided by real-time MRI., Nanomedicine : Nanotechnology, Biology, and Medicine, 11(3), 657-670. doi:10.1016/j.nano.2014.12.007 [doi]

Clément A, Zaragori T, Filosa R, Ovdiichuk O, Beaumont M, Collet C, Roeder E, Martin B, Maskali F, Barberi-Heyob M, Pouget C, Doyen M, Verger A., Multi-tracer and multiparametric PET imaging to detect the IDH mutation in glioma: a preclinical translational in vitro, in vivo, and ex vivo study, Cancer Imaging. 2022 Mar 18;22(1):16. doi: 10.1186/s40644-022-00454-6.

Li C, Xu X, McMahon N, Alhaj Ibrahim O, Sattar HA, Tichauer KM., Paired-Agent Fluorescence Molecular Imaging of Sentinel Lymph Nodes Using Indocyanine Green as a Control Agent for Antibody-Based Targeted Agents, Contrast Media Mol Imaging. 2019 Jan 3;2019:7561862.

Cyran, C. C., Sennino, B., Fu, Y., Rogut, V., Shames, D. M., Chaopathomkul, B., . . . Raatschen, H. J. (2012)., Permeability to macromolecular contrast media quantified by dynamic MRI correlates with tumor tissue assays of vascular endothelial growth factor (VEGF)., European Journal of Radiology, 81(5), 891-896. doi:10.1016/j.ejrad.2011.07.016 [doi]

Isal, S., Pierson, J., Imbert, L., Clement, A., Collet, C., Pinel, S., . . . Maskali, F. (2018)., PET imaging of (68)ga-NODAGA-RGD, as compared with (18)F-fluorodeoxyglucose, in experimental rodent models of engrafted glioblastoma., EJNMMI Research, 8(1), 51-018-0405-5. doi:10.1186/s13550-018-0405-5 [doi]

Buck, J. R., McKinley, E. T., Fu, A., Abel, T. W., Thompson, R. C., Chambless, L., . . . Manning, H. C. (2015)., Preclinical TSPO ligand PET to visualize human glioma xenotransplants: A preliminary study., PloS One, 10(10), e0141659. doi:10.1371/journal.pone.0141659 [doi]

Hardisty, M. R., Akens, M. K., Hojjat, S. P., Yee, A., & Whyne, C. M. (2012)., Quantification of the effect of osteolytic metastases on bone strain within whole vertebrae using image registration., Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 30(7), 1032-1039. doi:10.1002/jor.22045 [doi]

Li, L., Zhu, L., Ma, C., Lin, L., Yao, J., Wang, L., . . . Wang, L. V. (2017)., Single-impulse panoramic photoacoustic computed tomography of small-animal whole-body dynamics at high spatiotemporal resolution., Nature Biomedical Engineering, 1(5), 10.1038/s41551-017-0071. Epub 2017 May 10. doi:0071 [pii]

Shariati M, Lollo G, Matha K, Descamps B, Vanhove C, Van de Sande L, Willaert W, Balcaen L, Vanhaecke F, Benoit JP, Ceelen W, De Smedt SC, Remaut K., Synergy between Intraperitoneal Aerosolization (PIPAC) and Cancer Nanomedicine: Cisplatin-Loaded Polyarginine-Hyaluronic Acid Nanocarriers Efficiently Eradicate Peritoneal Metastasis of Advanced Human Ovarian Cancer, ACS Appl Mater Interfaces. 2020 Jul 1;12(26):29024-29036. doi: 10.1021/acsami.0c05554. Epub 2020 Jun 22.

Chevaleyre C, Kereselidze D, Caillé F, Tournier N, Olaciregui NG, Winkeler A, Declèves X, Jego B, Cisternino S, Auvity S, Truillet C., TSPO PET Imaging as a Potent Non-Invasive Biomarker for Diffuse Intrinsic Pontine Glioma in a Patient-Derived Orthotopic Rat Model, Int J Mol Sci. 2022 Oct 18;23(20):12476. doi: 10.3390/ijms232012476.

Surgical

Servetto A, Kollipara R, Formisano L, Lin CC, Lee KM, Sudhan DR, Gonzalez-Ericsson PI, Chatterjee S, Guerrero-Zotano A, Mendiratta S, Akamatsu H, James N, Bianco R, Hanker AB, Kittler R, Arteaga CL., Nuclear FGFR1 Regulates Gene Transcription and Promotes Antiestrogen Resistance in ER(+) Breast Cancer., Clin Cancer Res. 2021 Aug 1;27(15):4379-4396. doi: 10.1158/1078-0432.CCR-20-3905. Epub 2021 May 19.

Toxicology

Roohi Jeelani, Charalampos Chatzicharalampous, Hamid-Reza Kohan-Ghadr, Awoniyi Awonuga, Narendra Joshi, Robert T. Morris & Husam M. Abu-Soud, Acrolein, a commonly found environmental toxin, causes oocyte mitochondrial dysfunction and negatively affects embryo development, Free Radical Research, 52:9, 929-938, 2018.

Aasa, J., Granath, F., Tornquist, M., Cancer risk estimation of glycidol based on rodent carcinogenicity studies, a multiplicative risk model and in vivo dosimetry, Food and Chemical Toxicology Volume 128, June 2019, Pages 54-60

Roohi Jeelani et al., Cyclophosphamide and acrolein induced oxidative stress leading to deterioration of metaphase II mouse oocyte quality, Free Radical Biology and Medicine Volume 110, September 2017, Pages 11-18

Transplantation

Bansal A, Pandey MK, Yamada S, Goyal R, Schmit NR, Jeon R, Nesbitt JJ, Witt TA, Singh RD, Gunderson TM, Boroumand S, Li M, Crespo-Diaz RJ, Hillestad ML, Terzic A, Behfar A, DeGrado TR., [(89)Zr]Zr-DBN labeled cardiopoietic stem cells proficient for heart failure, Nucl Med Biol. 2020 Nov-Dec;90-91:23-30. doi: 10.1016/j.nucmedbio.2020.09.001. Epub 2020 Sep 9.

Xu, J., Li, K., Smith, R. A., Waterton, J. C., Zhao, P., Ding, Z., . . . Gore, J. C. (2017)., A comparative assessment of preclinical chemotherapeutic response of tumors using quantitative non-gaussian diffusion MRI, Magnetic Resonance Imaging, 37, 195-202. doi:S0730-725X(16)30239-9 [pii]

Caffrey, P. B., Frenkel, G. D., McAndrew, K. L., & Marks, K. (2016)., A model of the development of cisplatin resistance in human small cell lung cancer xenografts, In Vivo (Athens, Greece), 30(6), 745-749. doi:30/6/745 [pii]

Shimoda, M., Chen, S., Noguchi, H., Takita, M., Sugimoto, K., Itoh, T., . . . Grayburn, P. A. (2014)., A new method for generating insulin-secreting cells from human pancreatic epithelial cells after islet isolation transformed by NeuroD1., Human Gene Therapy Methods, 25(3), 206-219. doi:10.1089/hgtb.2013.122 [doi]

Curtin, C., Nolan, J. C., Conlon, R., Deneweth, L., Gallagher, C., Tan, Y. J., . . . Piskareva, O. (2018)., A physiologically relevant 3D collagen-based scaffold-neuroblastoma cell system exhibits chemosensitivity similar to orthotopic xenograft models. Acta, Acta Biomaterialia, 70, 84-97. doi:S1742-7061(18)30074-6 [pii]

Hou, F., Dai, Y., Suen, J. Y., Fan, C., Saad, A. G., & Richter, G. T. (2013)., A xenograft animal model of human arteriovenous malformations, Orphanet Journal of Rare Diseases, 8, 199-1172-8-199. doi:10.1186/1750-1172-8-199 [doi]

Borgogna, C., Olivero, C., Lanfredini, S., Calati, F., De Andrea, M., Zavattaro, E., . . . Gariglio, M. (2018)., Beta-HPV infection correlates with early stages of carcinogenesis in skin tumors and patient-derived xenografts from a kidney transplant recipient cohort., Frontiers in Microbiology, 9, 117. doi:10.3389/fmicb.2018.00117 [doi]

Yan, S., Zhang, R., Wu, K., Cui, J., Huang, S., Ji, X., . . . Weng, Y. (2018)., Characterization of the essential role of bone morphogenetic protein 9 (BMP9) in osteogenic differentiation of mesenchymal stem cells (MSCs) through RNA interference., Genes & Diseases, 5(2), 172-184. doi:10.1016/j.gendis.2018.04.006 [doi]

Yu Q, DiFeo Jacquet R, Landis WJ., Characterization of Tissue-Engineered Human Periosteum and Allograft Bone Constructs: The Potential of Periosteum in Bone Regenerative Medicine, Cells Tissues Organs. 2020;209(2-3):128-143. doi: 10.1159/000509036. Epub 2020 Sep 16.

Howard, C. B., McDowell, R., Feleke, K., Deer, E., Stamps, S., Thames, E., . . . Pervin, S. (2016)., Chemotherapeutic vulnerability of triple-negative breast cancer cell-derived tumors to pretreatment with vernonia amygdalina aqueous extracts., Anticancer Research, 36(8), 3933-3943. doi:36/8/3933 [pii]

Kilinc, M. O., Ehrig, K., Pessian, M., Minev, B. R., & Szalay, A. A. (2016)., Colonization of xenograft tumors by oncolytic vaccinia virus (VACV) results in enhanced tumor killing due to the involvement of myeloid cells., Journal of Translational Medicine, 14(1), 340-016-1096-1. doi:10.1186/s12967-016-1096-1 [doi]

Pastor, D., Viso-Leon, M. C., Jones, J., Jaramillo-Merchan, J., Toledo-Aral, J. J., Moraleda, J. M., & Martinez, S. (2012)., Comparative effects between bone marrow and mesenchymal stem cell transplantation in GDNF expression and motor function recovery in a motorneuron degenerative mouse model., Stem Cell Reviews, 8(2), 445-458. doi:10.1007/s12015-011-9295-x [doi]

Citro, L., Naidu, S., Hassan, F., Kuppusamy, M. L., Kuppusamy, P., Angelos, M. G., & Khan, M. (2014)., Comparison of human induced pluripotent stem-cell derived cardiomyocytes with human mesenchymal stem cells following acute myocardial infarction, PloS One, 9(12), e116281. doi:10.1371/journal.pone.0116281 [doi]

Corona, B. T., Henderson, B. E., Ward, C. L., & Greising, S. M. (2017)., Contribution of minced muscle graft progenitor cells to muscle fiber formation after volumetric muscle loss injury in wild-type and immune deficient mice., Physiological Reports, 5(7), 10.14814/phy2.13249. doi:e13249 [pii]

Rodriguez Calleja, L., Jacques, C., Lamoureux, F., Baud'huin, M., Tellez Gabriel, M., Quillard, T., . . . Ory, B. (2016)., DeltaNp63alpha silences a miRNA program to aberrantly initiate a wound-healing program that promotes TGFbeta-induced metastasis, Cancer Research, 76(11), 3236-3251. doi:10.1158/0008-5472.CAN-15-2317 [doi]

Lee, C. W., Guo, L., Matei, D., & Stantz, K. (2015)., Development of follicle-stimulating hormone receptor binding probes to image ovarian xenografts, Journal of Biotechnology & Biomaterials, 5(3), 10.4172/2155-952X.1000198. Epub 2015 Sep 10. doi:198 [pii]

Kiseljak-Vassiliades, K., Zhang, Y., Bagby, S. M., Kar, A., Pozdeyev, N., Xu, M., . . . Wierman, M. E. (2018)., Development of new preclinical models to advance adrenocortical carcinoma research., Endocrine-Related Cancer, 25(4), 437-451. doi:10.1530/ERC-17-0447 [doi]

Song D, Huang S, Zhang L, Liu W, Huang B, Feng Y, Liu B, He TC, Huang D, Reid RR., Differential Responsiveness to BMP9 between Patent and Fused Suture Progenitor Cells from Craniosynostosis Patients, Plast Reconstr Surg. 2020 Mar;145(3):552e-562e. doi: 10.1097/PRS.0000000000006597.

Yang, Y. C., Liem, A., Lambert, P. F., & Sugden, B. (2017)., Dissecting the regulation of EBV's BART miRNAs in carcinomas, Virology, 505, 148-154. doi:S0042-6822(17)30054-5 [pii]

Novella-Maestre, E., Herraiz, S., Vila-Vives, J. M., Carda, C., Ruiz-Sauri, A., & Pellicer, A. (2012)., Effect of antiangiogenic treatment on peritoneal endometriosis-associated nerve fibers., Fertility and Sterility, 98(5), 1209-1217. doi:10.1016/j.fertnstert.2012.07.1103 [doi]

Yu, X., Chen, L., Wu, K., Yan, S., Zhang, R., Zhao, C., . . . Gan, H. (2018)., Establishment and functional characterization of the reversibly immortalized mouse glomerular podocytes (imPODs)., Genes & Diseases, 5(2), 137-149. doi:10.1016/j.gendis.2018.04.003 [doi]

Rodriguez, M., Silva, J., Herrera, A., Herrera, M., Pena, C., Martin, P., . . . Garcia-Barberan, V. (2015)., Exosomes enriched in stemness/metastatic-related mRNAS promote oncogenic potential in breast cancer., Oncotarget, 6(38), 40575-40587. doi:10.18632/oncotarget.5818 [doi]

Hoppela, E., Gronroos, T. J., Saarikko, A. M., Tervala, T. V., Kauhanen, S., Nuutila, P., . . . Hartiala, P. (2018)., Fat grafting can induce browning of white adipose tissue., Plastic and Reconstructive Surgery.Global Open, 6(6), e1804. doi:10.1097/GOX.0000000000001804 [doi]

Hubmann, R., Sieghart, W., Schnabl, S., Araghi, M., Hilgarth, M., Reiter, M., . . . Shehata, M. (2017)., Gliotoxin targets nuclear NOTCH2 in human solid tumor derived cell lines in vitro and inhibits melanoma growth in xenograft mouse model., Frontiers in Pharmacology, 8, 319. doi:10.3389/fphar.2017.00319 [doi]

Bueno, C., Ramirez, C., Rodriguez-Lozano, F. J., Tabares-Seisdedos, R., Rodenas, M., Moraleda, J. M., . . . Martinez, S. (2013)., Human adult periodontal ligament-derived cells integrate and differentiate after implantation into the adult mammalian brain, Cell Transplantation, 22(11), 2017-2028. doi:10.3727/096368912X657305 [doi]

Sareen, D., Gowing, G., Sahabian, A., Staggenborg, K., Paradis, R., Avalos, P., . . . Svendsen, C. N. (2014)., Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord., The Journal of Comparative Neurology, 522(12), 2707-2728. doi:10.1002/cne.23578 [doi]

Melsens, E., De Vlieghere, E., Descamps, B., Vanhove, C., Kersemans, K., De Vos, F., . . . Pattyn, P. (2018)., Hypoxia imaging with (18)F-FAZA PET/CT predicts radiotherapy response in esophageal adenocarcinoma xenografts., Radiation Oncology (London, England), 13(1), 39-018-0984-3. doi:10.1186/s13014-018-0984-3 [doi]

Benavides, O. M., Brooks, A. R., Cho, S. K., Petsche Connell, J., Ruano, R., & Jacot, J. G. (2015)., In situ vascularization of injectable fibrin/poly(ethylene glycol) hydrogels by human amniotic fluid-derived stem cells., Journal of Biomedical Materials Research.Part A, 103(8), 2645-2653. doi:10.1002/jbm.a.35402 [doi]

Smink AM, Skrzypek K, Liefers-Visser JAL, Kuwabara R, de Haan BJ, de Vos P, Stamatialis D., In vivovascularization and islet function in a microwell device for pancreatic islet transplantation, Biomed Mater. 2021 Apr 21;16(3). doi: 10.1088/1748-605X/abf5ec.

Zhang B, Yang L, Zeng Z, Feng Y, Wang X, Wu X, Luo H, Zhang J, Zhang M, Pakvasa M, Wagstaff W, He F, Mao Y, Qin K, Ding H, Zhang Y, Niu C, Wu M, Zhao X, Wang H, Huang L, Shi D, Liu Q, Ni N, Fu K, Athiviraham A, Moriatis Wolf J, Lee MJ, Hynes K, Strelzow J, El Dafrawy M, Xia Y, He TC., Leptin Potentiates BMP9-Induced Osteogenic Differentiation of Mesenchymal Stem Cells Through the Activation of JAK/STAT Signaling, Stem Cells Dev. 2020 Apr 15;29(8):498-510. doi: 10.1089/scd.2019.0292. Epub 2020 Mar 9.

Brand, C., Sadique, A., Houghton, J. L., Gangangari, K., Ponte, J. F., Lewis, J. S., . . . Reiner, T. (2018), Leveraging PET to image folate receptor alpha therapy of an antibody-drug conjugate., EJNMMI Research, 8(1), 87-018-0437-x. doi:10.1186/s13550-018-0437-x [doi]

Page, J. M., Merkel, A. R., Ruppender, N. S., Guo, R., Dadwal, U. C., Cannonier, S., . . . Sterling, J. A. (2015)., Matrix rigidity regulates the transition of tumor cells to a bone-destructive phenotype through integrin beta3 and TGF-beta receptor type II., Biomaterials, 64, 33-44. doi:10.1016/j.biomaterials.2015.06.026 [doi]

Walker MM, Baumann ME, Alexander JH, Blackstone BN, Morgan CB, Scharschmidt TJ, Powell HM., Mechanical strain induces ex vivo expansion of periosteum, PLoS One. 2022 Dec 30;17(12):e0279519. doi: 10.1371/journal.pone.0279519. eCollection 2022.

Rooj, A. K., Ricklefs, F., Mineo, M., Nakano, I., Chiocca, E. A., Bronisz, A., & Godlewski, J. (2017)., MicroRNA-mediated dynamic bidirectional shift between the subclasses of glioblastoma stem-like cells., Cell Reports, 19(10), 2026-2032. doi:S2211-1247(17)30682-4 [pii]

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Sprague Dawley® outbred rats

Unveiling the Rodent Model Powerhouse: Why Sprague Dawley® Rats are Essential for Medical Research