Oct2 knockout rats: HsdSage:SD-Slc22a2em1Sage GEM rats

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Cryopreserved

Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.

Oct1 (-/-) rats have increased exposure to specific substrates

Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous as live colony

A related model Oct1 (-/-) rats have increased exposure to specific substrates

This model contains a biallelic deletion within the Slc22a2 solute carrier family 22 (organic cation transporter), member 2, encoding for the basolateral hepatocyte uptake transporter OCT2.

Oct2 is involved in disposition and excretion through its role in xenobiotic uptake in the basolateral membrane of the liver. Polymorphisms within the gene also have clinical relevance - making this a useful model for studying drug-drug interations, toxicity and metabolism in the liver.

Origin: The Oct2 KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.

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