B-NDG knockout mice
NOD.CB17-Prkdcscid IL2rgtm1/BcgenHsd
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Order code: 126
- Autosomal recessive, single nucleotide polymorphism with Prkdc gene on chromosome 16
- Coat: Albino
- Common gamma chain gene (II2rg) interrupted
- Deficiency in cytokine signaling
- Deficient in T and B cells
- High humanization capability
- Lacks functional receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21
- Lacks NK cells
- Severe lymphocyte development impairment
Origin:
The B-NDG model is a single knockout mouse with an ultra immunodeficient phenotype. The model was generated by Biocytogen by deleting the IL2rg gene from NOD-scid mice.
Prkdc (protein kinase DNA-activated catalytic) null scid mutation is characterized by significantly deficient of functional T cells and B cells.
The Common gamma chain gene (IL2RG) deletion results in a lack of functional receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21, which results in the lack of functional NK cells.
Envigo, now Inotiv, licensed the mouse model from Biocytogen in 2019, where the model had been maintained. The model is albino.
Available regions:
Asia-Pacific
Austria
Baltic states
Belgium
East Europe
France
Germany
Ireland
Italy
Portugal
Scandinavia
Spain
Switzerland
The Netherlands
United States
United Kingdom
Other regions
I. For-Profit (Commercial) Female Order code: 126 - Italy
| Description | Price | Currency |
|---|---|---|
| 3 weeks | 226.85 | EUR |
| 4 weeks | 233.20 | EUR |
| 5 weeks | 239.55 | EUR |
| 6 weeks | 7.40 | EUR |
| 7 weeks | 187.55 | EUR |
| 8 weeks | 195.35 | EUR |
| 9- weeks | 203.15 | EUR |
| Over 9 weeks, add per week | 8.35 | EUR |
I. For-Profit (Commercial) Male Order code: 126 - Italy
| Description | Price | Currency |
|---|---|---|
| 3 weeks | 171.40 | EUR |
| 4 weeks | 171.40 | EUR |
| 5 weeks | 171.40 | EUR |
| 6 weeks | 179.80 | EUR |
| 7 weeks | 187.55 | EUR |
| 8 weeks | 195.35 | EUR |
| 9 weeks | 203.15 | EUR |
| Over 9 weeks, add per week | 8.35 | EUR |
II. Non-Profit (Academic) Female Order code: 126 - Italy
| Description | Price | Currency |
|---|---|---|
| 3 weeks | 143.60 | EUR |
| 4 weeks | 143.60 | EUR |
| 5 weeks | 143.60 | EUR |
| 6 weeks | 148.05 | EUR |
| 7 weeks | 155.80 | EUR |
| 8 weeks | 163.60 | EUR |
| 9 weeks | 171.40 | EUR |
| Over 9 weeks, add per week | 7.80 | EUR |
II. Non-Profit (Academic) Male Order code: 126 - Italy
| Description | Price | Currency |
|---|---|---|
| 3 weeks | 143.60 | EUR |
| 4 weeks | 143.60 | EUR |
| 5 weeks | 143.60 | EUR |
| 6 weeks | 148.05 | EUR |
| 7 weeks | 155.80 | EUR |
| 8 weeks | 163.60 | EUR |
| 9 weeks | 171.40 | EUR |
| Over 9 weeks, add per week | 7.80 | EUR |
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Research Use and Related Publications
- Aging
- Chemoresistance
- General studies
- Immunotherapy
- Oncology
- Stem cells
- Tumor Cell Growth
- Tumor growth
- Humanization applications
- Infectious disease
