Trpv1 knockout rats: HsdSage:SD-Trpv1em1Sage GEM rats

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Cryopreserved

Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.

Background strain: Sprague Dawley
Homozygous knockout rats exhibit complete loss of Trpv1 protein
Trpv1 knockout rats show hyposensitivity to thermal pain via hot plate assay

Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous as live colony

This model contains a biallelic deletion of the Trpv1 gene, encoding for the transient receptor potential cation channel subfamily V member 1. Capsaicin, the component in chili peppers that makes them hot, is an exogenous ligand for Trpv1. Trpv1 is also activated by heat.

Trpv1 is a non-selective cation channel, activated by a range of stimuli including capsaicin, cannabinoids, and heat. Trpv1 activation results in the sensation of pain as well as the lowering of body temperature. Trpv1 antagonists are being pursued as potential novel analgesics.

Origin: The Trpv1 KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.

Available regions:

Asia-Pacific Austria Baltic states Belgium East Europe France Germany Ireland Italy Portugal Scandinavia Spain Switzerland The Netherlands United States United Kingdom Other regions

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