Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.

• Monoallelic 11 base pair deletion in Tp53
• Broad tumor spectrum
• High degree of tumor malignancy
• Background Strain: Sprague-Dawley

Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous as live colony

Homozygous null Tp53 rats display onset of tumors at ~4 months of age. A high degree of malignancy is observed across a broad spectrum of tumors. Heterozygous rats have a delayed onset of spontaneous tumors, making them valuable for carcinogenicity screening, as well as studying efficacy of chemopreventive and therapeutic treatment.

p53 is a tumor suppressor protein encoded by the Tp53 gene. Its role in cell cycle regulation and stabilization for preventing genome mutation is observable among a wide variety of multicellular organisms, including humans, rodents, frogs and fish. Heterozygous rats deficient in p53 protein are prone to spontaneous tumors, making them valuable for in vivo screening of carcinogenicity, as well as studying chemopreventive and therapeutic treatment.