Oat1 knockout rats
HsdSage:SD-Slc22a6em1Sage
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Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
Availability: Cryopreserved as hetrozygous embryos
Zygosity: Heterozygous as live colony
This model contains a biallelic deletion of the organic anion transporter 1 (OAT1), also known as solute carrier family 22 member 6 (SLC22A6). Oat1 plays a central role in renal organic anion transport. Along with Oat3, Oat1 mediates the uptake of a wide range of relatively small and hydrophilic organic anions from plasma into the cytoplasm of the proximal tubular cells of the kidneys- making this a useful model for studying drug-drug interactions, toxicity and metabolism in the liver.
The Oat1 Knockout Rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.
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- ADMET
- Drug-drug interactions
- Drug metabolism
- Drug transporter
- Hepatotoxicity
