Rag2 knockout rats (Sprague Dawley) HsdSage:SD-Rag2em1sage
Order Today
- 2 bp deletion within Exon 3 on chromosome 3
- Homozygous Rag2 knockout rats display loss of RAG2 protein via Western blot
- Homozygous Rag2 knockout rats show loss of B and T cells by FACS analysis
Availability: Live colony
Zygosity genotype: Homozygous
Rag2 knockout rats completely lack B and T cells, making them ideal immuno-compromised hosts for xenograft studies. In addition, the larger size of the rat makes performing sophisticated xenograft techniques and surgeries much simpler as compared to similar studies in a mouse.
Mature B and T cells are critical components for an adaptive immune system. Rats deficient in Rag2 protein produce no mature B or T cells. This non-leaky model for severe combined immune deficiency is useful for vaccine development, autoimmune and infectious diseases.
The Rag2 (Sprague-Dawley®) KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.
Available regions:
For pricing please contact us using the phone number above
us
- Infectious disease
- Oncology
- Vaccines
- Cancer metastasis
- Immunology
- Inflammation/Autoimmune disorders
- Hematopoieses
- Thrombosis/Cardiac fibrosis
- Vascular defects
- Xenograft
