Ppara knockout rats: HsdSage:SD-Pparaem1Sage GEM rats

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Cryopreserved

Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.

Background strain: Sprague Dawley
Homozygous knockout rats display total loss of protein via Western blot

Availability: Cryopreserved as heterozygous embryos
Zygosity: Homozygous as live colony

This model contains a bi-allelic deletion within the peroxisome proliferator-activated receptor alpha gene (Ppara).

Ppara (peroxisome proliferator-activated receptor alpha gene) is a ligand activated nuclear receptor, known to be activated by free fatty acids and their derivatives. Besides the studying of lipid metabolism and diabetes, Ppar-alpha affect the expression of target genes involved in cell proliferation, cell differentiation, and in immune and inflammation responses.

Origin: The Ppara KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.

Available regions:

Asia-Pacific Austria Baltic states Belgium East Europe France Germany Ireland Italy Portugal Scandinavia Spain Switzerland The Netherlands United States United Kingdom Other regions

For pricing please contact us using the phone number above