Oprm1 knockout rats: HsdSage:SD-Oprm1em1Sage GEM rats

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Cryopreserved

Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.

11 base pair deletion in exon 2
Background strain: Sprague Dawley
Early stop codon in exon 3

Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous as live colony

This model possesses an 11 base pair deletion in exon 2 of the Oprm1 gene, leading to an early stop codon in exon 3. Oprm1 encodes the mu opioid receptor 1 (MOR), the major target of most clinically used opioids. This model is useful for applications investigating nociception, and is particularly useful for discrimination among opioid receptor subtypes.

Origin: The Oprm1 KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.

Available regions:

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For pricing please contact us using the phone number above