Neurexin1-Nrxn1 knockout rats: HsdSage:SD-Nrxn1em1Sage GEM rats

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Cryopreserved

Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.

Background strain: Sprague Dawley
Biallelic 726 bp deletion within Nrxn1 gene
Decreased transport of endogenous glutathione
Homozygous knockouts display total loss of protein via Western blot
Hyperbilirubinemia

Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous as live colony

This model contains a biallelic deletion of the Neurexin 1 gene (Nrxn1). Mutations in Nrxn1 have been associated with autism spectrum disorders (ASD) and this model is useful for understanding the role of neurexins in the development of ASD.

Origin: The Neurexin1 - Nrxn1 KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.

Available regions:

Asia-Pacific Austria Baltic states Belgium East Europe France Germany Ireland Italy Portugal Scandinavia Spain Switzerland The Netherlands United States United Kingdom Other regions

For pricing please contact us using the phone number above