PXR/CAR/AHR knockout rats
HsdSage:SD-NR1i2/NR1i3/AHRem1Sage
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Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
- Biallelic 20 bp deletion within Nr1i2 gene
- Biallelic 10 bp deletion within Nr1i3 gene
- Biallelic 760 bp deletion within Ahr gene
- Background Strain: Sprague-Dawley
Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous for all alleles
PXR, CAR, and AHR are involved in the induction of cytochrome p4503A (Cyp3a) and are abundantly expressed in the liver and intestine. This model is useful for studying metabolism of xenobiotic compounds and hepatotoxicity.
This triple knockout model was generated by crossing together the three single PXR, Car, and AHR knockout rat lines.
The PXR/CAR/AHR Knockout Rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.
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- ADMET
- Cholestasis
- Cytochrome p450 pathways
- Drug metabolism
- Hepatotoxicity
- Xenobiotic
