• Background strain: Sprague Dawley
• Biallelic 20 bp deletion within Abcba1 gene and 588 bp deletion within the Abcg2 gene
• Homozygous knockouts exhibit complete loss of ApoE protein via Western blot
• Increased oral bioavailability of P-gp and Bcrp specific substrates

Availability: Live colony
Zygosity genotype: Homozygous

P-gp and Bcrp both play a critical role in efflux for brain. Double homozygous null Mdr1a-Bcrp rats display increased exposure to CNS drugs in the brain, as well as increased bioavailability in the plasma for P-gp and Bcrp specific substrates.

MDR1 and BCRP are membrane-bound drug transporters expressed in the brain. Each effectively blocks specific drugs from crossing the blood-brain barrier. P-gp and Bcrp can confer multiple drug resistance to tumor cells. Absence of P-gp and Bcrp creates a functional deficiency in the blood-brain barrier and results in elevated drug levels in many tissues, making this a useful model for efflux assay, efficacy, formulation, tissue distribution, studying neurotoxicology and chemotherapeutic agents.