Mdr1a knockout rats HsdSage:SD-Mdr1aem1Sage
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- Background strain: Sprague Dawley
- Biallelic 20 bp deletion within Abcba1 gene
- Homozygous knockout rats display total loss of protein via Western blot
- Increased oral bioavailability of P-gp-specific substrates
Availability: Live colony
Zygosity genotype: Homozygous
P-glycoprotein plays a critical role in efflux for both brain and liver. Homozygous null Mdr1a rats display increased exposure to CNS drugs in the brain, as well as increased bioavailability in the plasma for P-gp-specific substrates.
MDR1 encodes for P-glycoprotein and is a membrane-bound drug transporter expressed in the brain and intestine. It effectively blocks drugs from crossing the blood-brain barrier. P-gp can confer multiple drug resistance to tumor cells. Absence of P-gp creates a functional deficiency in the blood-brain barrier and results in elevated drug levels in many tissues, making this a useful model for efflux assay, efficacy, formulation, tissue distribution, studying neurotoxicology and chemotherapeutic agents.
The Mdr1a KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.
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us
- ADMET
- Pharmacology
- Blood brain barrier efflux
- DMPK assay
- Drug metabolism
- Drug resistance
- Drug transporter
- Efficacy
- Formulation drug-drug interactions
- Neurotoxicology
- PK-PD efflux assay
