Lgals1 (Gal1) knockout rats
HsdSage:SD-Lgals1em1Sage
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Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
- Homozygous knockout rats display loss of LGALS1 protein via Western blot
- Background Strain: Sprague-Dawley
Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous as live colony
Galectins have been implicated in inflammation and cancer, and are useful targets for development of new anti-inflammatory and anticancer therapies. LGALS1 (GAL1) may act as an autocrine negative growth factor that regulates cell proliferation.
The Lgals1 (Gal1) Knockout Rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.
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Available regions:
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us
- Asthma
- Colitis
- Crohn's disease
- Immunology
- Inflammation/Autoimmune disorders
- Multiple sclerosis
- Oncology
- Platelet defects/Platelet aggregation
- Renal dysplasia
- Rheumatoid arthritis
- Thrombosis/Cardiac fibrosis
- Vascular defects
