mGluR5 knockout rats HsdSage:SD-Grm5em1Sage
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Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
- Background strain: Sprague Dawley
- GlurR5 antagonists are being pursued as potential therapeutics for Fragile X syndrome and autism spectrum disorders
- mGluR5 is implicated in the neuropharmacology of cognition, anxiety, addiction and pain
- The function of this receptor is altered in Fragile X syndromem
Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous as live colony
This model contains a biallelic deletion of the metabotropic glutamate receptor 5 (mGluR5 or Grm5). mGluR5 function is altered in Fragile X syndrome, and mGluR5 has emerged as a promising drug target for both Fragile X syndrome and autism spectrum disorders.
The mGluR5 KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.
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us
- Neuroscience
- Anxiety
- Autism (ASD)
- Cognition
- Fragile X syndrome
- Pain
- Schizophrenia
