Generated in conjunction with Autism Speaks, this knockout rat model possesses an 8 bp deletion in the gamma-aminobutyric acid type A receptor beta3 subunit protein encoded by the Gabrb3 gene. Gabrb3 has been associated with several disorders including Prader-Willi syndrome, epilepsy and autism.
gem~gem rat~gem rats~knockout rats~knockout rat~Gabrb3 knockout rats~Gabrb3 knockout rat~Gabrb3~Gabrb3 rat~HsdSage:SD-Gabrb3tm1Sage~Cryopreserved~Gamma Aminobutyric~GABA~Gamma-Aminobutyric~Gamma-Aminobutyric Acid Type A Receptor Subunit Beta3~Gamma-Aminobutyric Acid (GABA) A Receptor, Beta 3~Gamma-Aminobutyric Acid Receptor Subunit Beta-3~Gamma-Aminobutyric Acid Type A Receptor Beta3 Subunit~Gamma-Aminobutyric Acid A Receptor Beta 3~GABA-Alpha Receptor Beta-2 Subunit~GABA(A) Receptor Subunit Beta-3~GABAA Receptor Beta-3 Subunit~GABA(A) Receptor, Beta 3~EIEE43~GABRB3~DEE43~ECA5
Origin: The Gabrb3 Knockout Rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.