Faah knockout rats
HsdSage:SD-Faahem1Sage
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Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
- Homozygous knockout rats exhibit complete loss of protein
- FAAH KO rats show an increased fear/startle reaction as observed in a functional observational battery (Irwin)
- FAAH KO rats show normal sensitivity to thermal pain via hot plate assay
- Background Strain: Sprague Dawley
Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous as live colony
This model contains a biallelic disruption of the Faah gene encoding the fatty acid amide hydrolase. FAAH is a serine hydrolase responsible for the breakdown of endocannabinoids. This model is useful for the study of cannabinoid biology including nociception.
Cannabinoids perform a variety of functions including the regulation of nociception. FAAH KO rats lack the enzyme responsible for endocannabinoid degradation,and endocannabinod levels should be elevated in this model.
The Faah Knockout Rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.
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us
- Analgesia
- Cannabinoids
- Neuroscience
- Nociception
- Pain
