Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.

• Disc1 is involved in neuronal growth and cortical development
• The protein also regulates the proliferation of embryonic and adult neuronal progenitor cells through the GSK3/ß-catenin pathway
• Preliminary reports suggest impaired prepulse inhibition in Disc1 knockout rats
• Background Strain: Sprague-Dawley

Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous as live colony

This model contains a biallelic deletion within the Disc1 (disrupted in schizophrenia 1) gene, encoding the DISC1 protein. A translocation disrupting Disc1 was discovered to co-segregate with major psychiatric illness in a Scottish family. This model is useful in the study of schizophrenia.

Disc1 is involved in neuronal growth and cortical development. The protein also regulates the proliferation of embryonic and adult neural progenitor cells through the GSK3/ß-catenin pathway. Disc1 was first identified through a translocation that segregates with schizophrenia and related psychiatric disorders in a large Scottish family, making this model useful for the study of Schizophrenia, Bipolar disorder and neuronal development.Disc1 was cryopreserved at the 12th generation.