Cox2 knockout rats
HsdSage:SD-Cox2em1Sage
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Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
- Homozygous knockouts display loss of COX2 protein via Western blot
- Background Strain: Sprague-Dawley
Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous
COX2 is one of the isoenzymes from Cyclooxygenase (COX) family and is responsible for inflammation and pain. Several pain relieving drugs such as Celecoxib and Rofecoxib selectively target COX2.
The Cox2 Knockout Rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.
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us
- Asthma
- Colitis
- Crohn's disease
- Immunology
- Inflammation/Autoimmune disorders
- Multiple sclerosis
- Platelet defects/Platelet aggregation
- Renal dysplasia
- Rheumatoid arthritis
- Thrombosis/Cardiac fibrosis
- Vascular defects
