Cox1 knockout rats

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Cryopreserved

Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.

Homozygous knockout rats exhibit complete loss of COX1 protein via Western blot
Background Strain: Sprague-Dawley

Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous

Cyclooxygenase (COX), also known as prostaglandin synthase (PHS) and prostaglandin endoperoxide synthetase (PES), is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. Rats deficient in COX1 can be used for studying inflammation, thrombosis, vascular defects, platelet defects and alterations in platelet aggregation.

Origin:

The Cox1 Knockout Rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.

Available regions:

Asia-Pacific Austria Baltic states Belgium East Europe France Germany Ireland Italy Portugal Scandinavia Spain Switzerland The Netherlands United States United Kingdom Other regions

For pricing please contact us using the phone number above