Mrp2 knockout rats: HsdSage:SD-Abcc2em1Sage GEM rats

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Cryopreserved

Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.

Background strain: Sprague Dawley
Biallelic 726 bp deletion within Abcc2 gene
Decreased transport of endogenous glutathione
Homozygous knockout rats display total loss of protein via Western blot
Hyperbilirubinemia

Availability: Cryopreserved as heterozygous embryos
Zygosity: Homozygous as live colony

Homozygous Mrp2 null rats display compromised biliary excretion and hyperbilirubinemia. This results in accumulation of glutathione-conjugated drugs in the liver.

Mrp2 is expressed in the liver and functions in biliary transport. The gene's substrates include anticancer compounds such as vinblastine, enabling it to confer multiple drug resistance to tumor cells. This model is useful for forumational, efficacy, tissue distribution, and DMPK assays

Origin: The Mrp2 KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.

Available regions:

Asia-Pacific Austria Baltic states Belgium East Europe France Germany Ireland Italy Portugal Scandinavia Spain Switzerland The Netherlands United States United Kingdom Other regions

For pricing please contact us using the phone number above