Mrp1 knockout rats: HsdSage:SD-Abcc1aem1Sage GEM rats

select features

Cryopreserved

Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.

Background strain: Sprague Dawley
Decreased transport of glutatione-conjugated substrates
Homozygous knockout rats display total loss of protein via Western blot
Increased bioavailability of specific substrate Fluorescein

Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous as live colony

This model contains a 43 base pair bi-allelic deletion within the Mrp1 gene, synonym Abcc1a (ATP-binding cassette, sub-family C [CFTR/MRP], member 1a), encoding an ATP-dependent drug transporter.

Mrp1 is a multispecific organic anion transporter that extrudes glutathione-, glucouronide- or sulfate-conjugated substrates (steroids, leukotrienes, etc.), as well as xenobiotic drugs out of cells. Mrp1 can confer multiple drug resistance to tumor cells. Absence of Mrp1 creates a functional deficiency in the cellular transport of some substrates and results in compromised inflammatory response, making this model useful for studying drug transport in inflammatory stimulus response and chemotherapeutic agents.

Origin: The Mrp1 KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.

Available regions:

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