Vgat-Cre knockin rats: HsdSage:LE-VGATem1(IRES-Cre)Sage GEM rats

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Cryopreserved

Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.

Background strain: Long Evans Hooded
Cre recombinase driven by endogenous Vgat promoter
No observed ectopic expression of cre
Targeted insertion eliminates possible gene disruption that may occur in random insertion technologies such as BAC

Availability: Cryopreserved as heterozygous embryos
Zygosity genotype: Homozygous as live colony

This model expresses cre-recombinase under the control of the endogenous solute carrier family 32 member 1 (Vgat) promoter enabling specific expression in Vgat positive GABAergic neurons. This model possesses a targeted insertion of (IRES)-cre immediately after the translational stop in the open reading frame of the Vgat gene. The Vgat-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines.

Origin:

The Vgat-Cre KI rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.

Available regions:

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