Rag2 knockout rats (Fischer 344): F344-Rag2em1Sage/SageHsd GEM rats

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Cryopreserved

Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.

Background Strain: Fischer 344

Availability: Cryopreserved as heterozygous embryos
Zygosity: Homozygous as live colony

Rag2 knockout rats completely lack B and T cells, making them ideal immuno-compromised hosts for xenograft studies. In addition, the larger size of the rat makes performing sophisticated xenograft techniques and surgeries much simpler as compared to similar studies in a mouse.

Mature B and T cells are critical components for an adaptive immune system. Rats deficient in Rag2 protein produce no mature B or T cells. This non-leaky model for severe combined immune deficiency is useful for vaccine development, autoimmune and infectious diseases.

Origin:

The Rag2 Knockout Rat (Fischer 344) model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.

Available regions:

Asia-Pacific Austria Baltic states Belgium East Europe France Germany Ireland Italy Portugal Scandinavia Spain Switzerland The Netherlands United States United Kingdom Other regions

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Research Use and Related Publications