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PXR knockout rats
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ADMET
ADMET
Haines C, Chatham LR, Vardy A, Elcombe CR, Foster JR, Lake BG.,
Comparison of the hepatic and thyroid gland effects of sodium phenobarbital and pregnenolone-16?-carbonitrile in wild-type and constitutive androstane receptor (CAR)/pregnane X receptor (PXR) knockout rats.,
Xenobiotica. 2019 Feb;49(2):227-238.
Haines C, Chatham LR, Vardy A, Elcombe CR, Foster JR, Lake BG.,
Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16?-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats.,
Toxicology. 2018 May 1;400-401:20-27.
Forbes KP, Kouranova E, Tinker D, Janowski K, Cortner D, McCoy A, Cui X.,
Creation and Preliminary Characterization of Pregnane X Receptor and Constitutive Androstane Receptor Knockout Rats.,
Drug Metab Dispos. 2017 Oct;45(10):1068-1076.
Hunter SR, Vonk A, Mullen Grey AK, Riddick DS.,
Role of Glucocorticoid Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and NADPH-Cytochrome P450 Oxidoreductase.,
Drug Metab Dispos. 2017 Feb;45(2):118-129.
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