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Pink1 knockout rats (Park6)

Related publications
Neuroscience
Parkinson's disease
Stress-induced neurological dysfunction

Neuroscience

DeAngelo VM, Hilliard JD, McConnell GC., Dopaminergic but not cholinergic neurodegeneration is correlated with gait disturbances in PINK1 knockout rats., Behav Brain Res. 2022 Jan 24;417:113575. doi: 10.1016/j.bbr.2021.113575. Epub 2021 Sep 14.
Ferris CF, Morrison TR, Iriah S, Malmberg S, Kulkarni P, Hartner JC, Trivedi M., Evidence of Neurobiological Changes in the Presymptomatic PINK1 Knockout Rat. J Parkinsons Dis. 2018;8(2):281-301. doi: 10.3233/JPD-171273., Translational psychiatry Vol.5, 2015
Dagda RK, Dagda RY, Vazquez-Mayorga E, Martinez B, Gallahue A., Intranasal Administration of Forskolin and Noopept Reverses Parkinsonian Pathology in PINK1 Knockout Rats., Mol Metab. 2022;66:101631. doi:10.1016/j.molmet.2022.101631
Vazquez-Mayorga E, Grigoruta M, Dagda R, Martinez B, Dagda RK., Intraperitoneal Administration of Forskolin Reverses Motor Symptoms and Loss of Midbrain Dopamine Neurons in PINK1 Knockout Rats., J Parkinsons Dis. 2022;12(3):831-850. doi: 10.3233/JPD-213016.
Nisbet AF, Lenell C, Glass T, Ciucci M., Neuromuscular Pathology of Extrinsic Tongue Muscles in the Pink1-/- Rat Model of Parkinson Disease, Behav Brain Res. 2022;424:113774. doi:10.1016/j.bbr.2022.113774
Sharma, A., Bazylianska, V., & Moszczynska, A., Parkin-deficient rats are resistant to neurotoxicity of chronic high-dose methamphetamine, Experimental Neurology 345 (2021): 113811.
Grigoruţă M, Martínez-Martínez A, Dagda RY, Dagda RK., Psychological Stress Phenocopies Brain Mitochondrial Dysfunction and Motor Deficits as Observed in a Parkinsonian Rat Model., Sleep Vol.41, 2018. Mol Neurobiol. 2020 Apr;57(4):1781-1798. doi: 10.1007/s12035-019-01838-9. Epub 2019 Dec 14.
Kelm-Nelson CA, Trevino MA, Ciucci MR., Quantitative Analysis of Catecholamines in the Pink1 -/- Rat Model of Early-onset Parkinson's Disease. Neuroscience. 2018 May 21;379:126-141. doi: 10.1016/j.neuroscience.2018.02.027. Epub 2018 Feb 27., European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology Vol.25, 2015
Pinizzotto CC, Dreyer KM, Aje OA, Caffrey RM, Madhira K, Kritzer MF., Spontaneous Object Exploration in a Recessive Gene Knockout Model of Parkinson's Disease: Development and Progression of Object Recognition Memory Deficits in Male Pink1-/- Rats, Genes Brain Behav. 2022;21(1):e12741. doi:10.1111/gbb.12741
Stauch KL, Villeneuve LM, Purnell PR, Pandey S, Guda C, Fox HS., SWATH-MS proteome profiling data comparison of DJ-1, Parkin, and PINK1 knockout rat striatal mitochondria. Data Brief. 2016 Sep 23;9:589-593. eCollection 2016 Dec., European archives of psychiatry and clinical neuroscience Vol.266, 2016
Barnett DGS, Lechner SA, Gammie SC, Kelm-Nelson CA., Thyroarytenoid Oxidative Metabolism and Synaptic Signaling Dysregulation in the Female Pink1-/- Rat, Laryngoscope. 2023 Dec;133(12):3412-3421. doi: 10.1002/lary.30768. Epub 2023 Jun 9.

Parkinson's disease

Stauch, K. L., Totusek, S., Farmer, T., Lamberty, B. G., Dyball, K. N., Almikhlafi, M. A., & Fox, H. S., Applying the RatWalker System for Gait Analysis in a Genetic Rat Model of Parkinson's Disease, JoVE (Journal of Visualized Experiments) 167 (2021): e62002.
Johnson RA, Kelm-Nelson CA, Ciucci MR., Changes to Ventilation, Vocalization, and Thermal Nociception in the Pink1-/- Rat Model of Parkinson's Disease, J Parkinsons Dis. 2020;10(2):489-504. doi: 10.3233/JPD-191853.
DeAngelo, V., Hilliard, J., McConnell, G., Dopaminergic but not cholinergic neurodegeneration is correlated with gait disturbances in PINK1 knockout rats, Behavioural Brain Research Volume 417, 24 January 2022, 113575
Creed RB, Goldberg MS., Enhanced Susceptibility of PINK1 Knockout Rats to Îą-Synuclein Fibrils, Neuroscience. 2020 Jun 15;437:64-75. doi: 10.1016/j.neuroscience.2020.04.032. Epub 2020 Apr 27.
Glass TJ, Kelm-Nelson CA, Szot JC, Lake JM, Connor NP, Ciucci MR., Functional characterization of extrinsic tongue muscles in the Pink1-/- rat model of Parkinson disease, PLoS One. 2020 Oct 16;15(10):e0240366. doi: 10.1371/journal.pone.0240366. eCollection 2020.
Kelm-Nelson CA, Gammie S., Gene expression within the periaqueductal gray is linked to vocal behavior and early-onset parkinsonism in Pink1 knockout rats, BMC Genomics. 2020 Sep 17;21(1):625. doi: 10.1186/s12864-020-07037-4.
Lamberty, B. G., Estrella, L. D., Mattingly, J. E., Emanuel, K., Trease, A., Totusek, S., Sheldon, L., George, J. W., Almikhlafi, M. A., Farmer, T., & Stauch, K. L., Parkinson's disease relevant pathological features are manifested in male Pink1/Parkin deficient rats, Brain, behavior, & immunity - health, 31, 100656. https://doi.org/10.1016/j.bbih.2023.100656
Hoffmeister, J. D., Kelm-Nelson, C. A., & Ciucci, M. R., Quantification of brainstem norepinephrine relative to vocal impairment and anxiety in the Pink1-/- rat model of Parkinson disease, Behavioural Brain Research 414 (2021): 113514.
Lechner, S. A., Kletzien, H., Gammie, S. C., & Kelm?Nelson, C. A., Thyroarytenoid Muscle Gene Expression in a Rat Model of Early-Onset Parkinson's Disease, The Laryngoscope (2021).

Stress-induced neurological dysfunction

Grigoruţă M, Dagda RK, Díaz-Sánchez ÁG, Martínez-Martínez A., Psychological distress and lack of PINK1 promote bioenergetics alterations in peripheral blood mononuclear cells, Sci Rep. 2020 Jun 17;10(1):9820. doi: 10.1038/s41598-020-66745-9.
Decoration

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