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Park2 Parkin knockout rats

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Metabolism
Neuroscience
Other
Parkinson's disease

Metabolism

Madhu V, Hernandez-Meadows M, Boneski PK, Qiu Y, Guntur AR, Kurland IJ, Barve RA, Risbud MV., The mitophagy receptor BNIP3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc, Autophagy. 2023 Jun;19(6):1821-1843. doi: 10.1080/15548627.2022.2162245. Epub 2023 Jan 10.

Neuroscience

Creed RB, Menalled L, Casey B, Dave KD, Janssens HB, Veinbergs I, van der Hart M, Rassoulpour A, Goldberg MS., Basal and Evoked Neurotransmitter Levels in Parkin, DJ-1, PINK1 and LRRK2 Knockout Rat Striatum., Neuroscience. 2019 Jun 15;409:169-179.
Gemechu, Jickssa M; Sharma, Akhil; Yu, Dongyue; Xie, Yuran; Merkel, Olivia M; Moszczynska, Anna;, Characterization of Dopaminergic System in the Striatum of Young Adult Park2-/- Knockout Rats., Scientific reports Vol.8, 2018
Cortese GP, Zhu M, Williams D, Heath S, Waites CL., Parkin Deficiency Reduces Hippocampal Glutamatergic Neurotransmission by Impairing AMPA Receptor Endocytosis., J Neurosci. 2016 Nov 30;36(48):12243-12258.
Sharma, A., Harutyunyan, A., Schneider, B. L., & Moszczynska, A., Parkin regulates drug-taking behavior in rat model of methamphetamine use disorder, Translational psychiatry 11, no. 1 (2021): 1-14.
Dave KD, De Silva S, Sheth NP, Ramboz S, Beck MJ, Quang C, Switzer RC 3rd, Ahmad SO, Sunkin SM, Walker D, Cui X, Fisher DA, McCoy AM, Gamber K, Ding X, Goldberg MS, Benkovic SA, Haupt M, Baptista MA, Fiske BK, Sherer TB, Frasier MA., Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease., Neurobiol Dis. 2014 Oct;70:190-203.
Stauch KL, Villeneuve LM, Purnell PR, Pandey S, Guda C, Fox HS., SWATH-MS proteome profiling data comparison of DJ-1, Parkin, and PINK1 knockout rat striatal mitochondria., Data Brief. 2016 Sep 23;9:589-593

Other

Stauch, K. L., Totusek, S., Farmer, T., Lamberty, B. G., Dyball, K. N., Almikhlafi, M. A., & Fox, H. S., Applying the RatWalker System for Gait Analysis in a Genetic Rat Model of Parkinson's Disease, JoVE (Journal of Visualized Experiments) 167 (2021): e62002.

Parkinson's disease

Lamberty, B. G., Estrella, L. D., Mattingly, J. E., Emanuel, K., Trease, A., Totusek, S., Sheldon, L., George, J. W., Almikhlafi, M. A., Farmer, T., & Stauch, K. L., Parkinson's disease relevant pathological features are manifested in male Pink1/Parkin deficient rats, Brain, behavior, & immunity - health, 31, 100656. https://doi.org/10.1016/j.bbih.2023.100657
Decoration

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