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hApoE4 knockin rats

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Alzheimer's disease
Cardiovascular
Neuroscience

Alzheimer's disease

Kulkarni P, Grant S, Morrison TR, Cai X, Iriah S, Kristal BS, Honeycutt J, Brenhouse H, Hartner JC, Madularu D, Ferris CF., Characterizing the human APOE epsilon 4 knock-in transgene in female and male rats with multimodal magnetic resonance imaging, Brain Res. 2020 Nov 15;1747:147030. doi: 10.1016/j.brainres.2020.147030. Epub 2020 Jul 31.
Emam S, Nasrollahpour M, Colarusso B, Cai X, Grant S, Kulkarni P, Ekenseair A, Gharagouzloo C, Ferris CF, Sun NX., Detection of presymptomatic Alzheimer's disease through breath biomarkers, Alzheimers Dement (Amst). 2020 Oct 14;12(1):e12088. doi: 10.1002/dad2.12088. eCollection 2020.
Lee BH, Cevizci M, Lieblich SE, Galea LAM., Sex-specific influences of APOEε4 genotype on hippocampal neurogenesis and progenitor cells in middle-aged rats, Biol Sex Differ. 2025 Feb 5;16(1):10. doi: 10.1186/s13293-025-00694-8.
Lee BH, Cevizci M, Lieblich SE, Ibrahim M, Wen Y, Eid RS, Lamers Y, Duarte-Guterman P, Galea LAM., Exploring the parity paradox: Differential effects on neuroplasticity and inflammation by APOEe4 genotype at middle age, Brain Behav Immun. 2024 Aug;120:54-70. doi: 10.1016/j.bbi.2024.05.019. Epub 2024 May 19.

Cardiovascular

Wu, Y.; Johnson, G.; Zhao, F.; Wu, Y.; Zhao, G.; Brown, A.; You, S.; Zou, M.-H.; Song, P., Features of Lipid Metabolism in Humanized ApoE Knockin Rat Models, International Journal of Molecular Sciences. 2021; 22(15):8262.
Wu Y, Zhao F, Sure VN, Ibrahim A, Yu C, Carr SM, Song P., Human ApoE2 Endows Stronger Contractility in Rat Cardiomyocytes Enhancing Heart Function, Cells. 2023 Jan 17;12(3):347. doi: 10.3390/cells12030347.

Neuroscience

Har-Paz, Ilona, Elor Arieli, and Anan Moran, ApoE4 attenuates cortical neuronal activity in young behaving apoE4 rats, Neurobiology of Disease 155 (2021): 105373
Decoration

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